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All about: Flavoxate

Big Image Pronouncation: (flay-voke-sate)
Class: Urinary tract antispasmodic, Alkalinizer

Trade Names:
Urispas
- Tablets 100 mg

Mechanism of Action

Pharmacology

Counteracts smooth muscle spasms of urinary tract.

Pharmacokinetics

Absorption

Well absorbed from GI tract.

Elimination

10% to 30% excreted renally within 6 h; 57% excreted in 24 h.

Onset

55 min.

Peak

112 min.

Indications and Usage

Symptomatic relief of dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence associated with cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.

Contraindications

Pyloric or duodenal obstruction; obstructive intestinal lesions or ileus; achalasia; GI hemorrhage; obstructive uropathies of lower urinary tract.

Dosage and Administration

Adults and Children (older than 12 yr of age)

PO 100 to 200 mg 3 to 4 times/day.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Cardiovascular

Tachycardia; palpitations.

CNS

Nervousness; headache; drowsiness; mental confusion.

Dermatologic

Urticaria and other dermatoses.

EENT

Vertigo; blurred vision, ocular tension; disturbances in accommodation.

GI

Nausea; vomiting; dry mouth.

Genitourinary

Dysuria.

Hematologic

Eosinophilia; leukopenia.

Miscellaneous

High fever.

Precautions

Pregnancy

Category B .

Lactation

Undetermined.

Children

Safety and efficacy in children younger than 12 yr of age not established.

Glaucoma

Give cautiously to patients with suspected glaucoma.

Patient Information

  • Caution patient against performing potentially hazardous activities until effects of product are well-tolerated.
  • Instruct patient to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
  • Advise patient to report these symptoms to health care provider: persistent or worsening dry mouth, hives, rash, nausea or vomiting, unusual nervousness, vertigo, headache, drowsiness, confusion, high fever, dysuria, tachycardia, palpitations, vision problems.

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