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All about: Flolan

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Generic Name: Epoprostenol (E-poe-PROST-en-ol)
Brand Name: Flolan

Flolan is used for:

Treating high blood pressure in the blood vessels associated with the lungs. It may also be used for other conditions as determined by your doctor.

Flolan is a prostaglandin. It works by relaxing the blood vessels and increasing blood to the lungs, which reduces the workload on the heart.

Do NOT use Flolan if:

  • you are allergic to any ingredient in Flolan
  • you have severe left-sided congestive heart failure

Contact your doctor or health care provider right away if any of these apply to you.

Before using Flolan :

Some medical conditions may interact with Flolan . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have previously taken Flolan and developed fluid in the lungs

Some MEDICINES MAY INTERACT with Flolan . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Antihypertensives (eg, verapamil, hydralazine) or thiazide diuretics (eg, hydrochlorothiazide) because additional reductions in blood pressure may occur
  • Anticoagulants (eg, warfarin) or antiplatelet medicines (eg, aspirin) because the risk of bleeding may be increased by Flolan
  • Digoxin because the risk of its side effects may be increased by Flolan .

This may not be a complete list of all interactions that may occur. Ask your health care provider if Flolan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Flolan :

Use Flolan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Flolan is administered continuously through a permanent indwelling catheter (intravenous [IV] line) using an IV infusion pump. If you are using Flolan at home, carefully follow the injection procedures taught to you by your health care provider. Ask your doctor or pharmacist any questions that you may have about Flolan or giving infusions.
  • Flolan should be mixed only with the sterile solution it is supplied with. The mixed medicine should not be mixed with other solutions or medicines.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Flolan , contact your doctor right away.

Ask your health care provider any questions you may have about how to use Flolan .

Important safety information:

  • Flolan may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Flolan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Flolan should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Flolan while you are pregnant. It is not known if Flolan is found in breast milk. If you are or will be breast-feeding while you use Flolan , check with your doctor. Discuss any possible risks to your baby.

If you suddenly stop taking Flolan , you may experience WITHDRAWAL symptoms, including difficulty breathing, dizziness, and weakness.

Possible side effects of Flolan :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; agitation; anxiety; back pain; bleeding, pain, redness, or swelling at injection site; diarrhea; dizziness; flushing; headache; muscle or jaw pain; nausea; stomach pain; stomach upset; sweating; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; irregular heartbeat; swelling in the abdomen; unusual or increased bruising; weakness.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include diarrhea; fainting; flushing; headache; lightheadedness; nausea; rapid heart rate; vomiting.

Proper storage of Flolan :

Flolan is usually handled and stored by a health care provider. If you are using Flolan at home, store Flolan as directed by your pharmacist or health care provider. Keep Flolan out of the reach of children and away from pets.

General information:

  • If you have any questions about Flolan , please talk with your doctor, pharmacist, or other health care provider.
  • Flolan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Flolan . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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