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All about: Fondaparinux

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Generic Name: Fondaparinux (fon-da-PARE-i-nux)
Brand Name: Arixtra

Tell your doctor you are using Fondaparinux before having any procedures involving spinal anesthesia (puncture). Using Fondaparinux before these types of procedures may cause major bruising or bleeding (epidural or spinal hematoma) inside your body or spinal cord, leading to possibly permanent paralysis.


Fondaparinux is used for:

Preventing the formation of harmful blood clots, especially after hip or knee surgery. Fondaparinux is also used with warfarin to treat blood clots in the leg or lungs. It may also be used for other conditions as determined by your doctor.

Fondaparinux is an anticoagulant. It works by inhibiting one of the steps necessary for the formation of blood clots, which helps prevent clots from developing or worsening.

Do NOT use Fondaparinux if:

  • you are allergic to any ingredient in Fondaparinux
  • you have severe kidney problems
  • you have certain heart infections (eg, bacterial endocarditis)
  • you are actively bleeding or have severe bleeding problems
  • you weigh less than 110 pounds (50 kg) and are using Fondaparinux to treat a blood clot in the lungs or legs
  • you weigh less than 110 pounds (50 kg) and will be having hip or knee replacement surgery or abdominal surgery, or you have had a hip fracture

Contact your doctor or health care provider right away if any of these apply to you.

Before using Fondaparinux :

Some medical conditions may interact with Fondaparinux . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breastfeeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have suffered a stroke or have had recent brain, eye, or spine surgery
  • if you have uncontrolled high blood pressure, ulcers, kidney problems, eye disease caused by diabetes, or a history of bleeding disorders

Some MEDICINES MAY INTERACT with Fondaparinux . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticoagulants (eg, warfarin), mifepristone, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen), or platelet inhibitors (eg, clopidogrel) because they may increase the risk of bleeding

This may not be a complete list of all interactions that may occur. Ask your health care provider if Fondaparinux may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Fondaparinux :

Use Fondaparinux as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Fondaparinux is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Fondaparinux at home, carefully follow the injection procedures taught to you by your health care provider.
  • If Fondaparinux contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into muscle.
  • Use a different injection site each day to prevent problems at the injection site (eg, hematomas).
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Fondaparinux , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Fondaparinux .

Important safety information:

  • Fondaparinux may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Fondaparinux .
  • LAB TESTS, including complete blood cell counts, kidney function tests, and stool blood tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Fondaparinux with caution in the ELDERLY because they may be more sensitive to its effects, especially bleeding.
  • Use Fondaparinux with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Fondaparinux during pregnancy. It is unknown if Fondaparinux is excreted in breast milk. If you are or will be breast-feeding while you are using Fondaparinux , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Fondaparinux :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bleeding, irritation, rash, or itching at the injection site; chills; constipation; diarrhea; headache; minor bleeding; nausea; sleeplessness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black stools; confusion; fever; one-sided weakness; slurred speech; swelling; unusual or severe bleeding or bruising; unusual tiredness or fatigue; vision problems.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include excessive bleeding and bruising.

Proper storage of Fondaparinux :

Store Fondaparinux at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fondaparinux out of the reach of children and away from pets.

General information:

  • If you have any questions about Fondaparinux , please talk with your doctor, pharmacist, or other health care provider.
  • Fondaparinux is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Fondaparinux . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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