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All about: Glyburide/Metformin

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Generic Name: Glyburide/Metformin Tablets (GLYE-bure-ide/met-FOR-min)
Brand Name: Glucovance

The metformin in this combination medicine may rarely cause a serious and sometimes fatal condition called lactic acidosis. Most of these cases have occurred in diabetic patients who also have certain kidney problems. The risk of lactic acidosis may be greater if you have liver problems, kidney problems, or heart failure. The risk may also be greater in patients who are elderly or drink alcohol. Lab tests, including kidney function, may be performed while you take Glyburide/Metformin .

Do not begin to take Glyburide/Metformin if you are more than 80 years old unless lab tests show that you do not have decreased kidney function. Do not take it if you have a severe infection, have low blood oxygen levels, or are dehydrated. Tell your doctor you take Glyburide/Metformin before you have any surgery or lab procedures.

Contact your doctor right away if you notice symptoms such as muscle pain or tenderness; unusual drowsiness, dizziness, or lightheadedness; slow or irregular heartbeat; fast or difficult breathing; unusual stomach discomfort; or unusual weakness or tiredness. Contact your doctor right away if you start to feel unusually cold, or if you have a general feeling of being unwell.


Glyburide/Metformin is used for:

Treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicine.

Glyburide/Metformin is a sulfonylurea and biguanide antidiabetic combination. It causes the pancreas to release insulin, which helps to lower blood sugar levels. It also decreases the amount of sugar that the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce.

Do NOT use Glyburide/Metformin if:

  • you are allergic to any ingredient in Glyburide/Metformin
  • you have congestive heart failure that is treated by medicine
  • you have a severe infection, low blood oxygen levels, kidney or liver problems, or high blood ketone or acid levels (eg, diabetic ketoacidosis), or you are severely dehydrated
  • you have had a stroke or a recent heart attack, or you are in shock
  • you are 80 years old or older and have not had a kidney function test
  • you will be having surgery or certain lab procedures
  • you are taking bosentan

Contact your doctor or health care provider right away if any of these apply to you.

Before using Glyburide/Metformin :

Some medical conditions may interact with Glyburide/Metformin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of heart problems (eg, heart failure, heart attack), blood vessel problems, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, or lactic acidosis
  • if you have type 1 diabetes, vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B12 levels, or anemia, or if you are dehydrated
  • if you have an infection, fever, recent injury, or moderate to severe burns
  • if you drink alcohol or have a history of alcohol abuse
  • if you will be having surgery or certain lab procedures
  • if you take a beta-blocker (eg, propranolol)

Some MEDICINES MAY INTERACT with Glyburide/Metformin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Bosentan because liver problems may occur; the effectiveness of both medicines also may be decreased
  • Beta-blockers (eg, propranolol) because the risk of low blood sugar may be increased. They may also hide certain signs of low blood sugar and make it more difficult to notice
  • Anticoagulants (eg, warfarin), azole antifungals (eg, miconazole), chloramphenicol, clofibrate, fenfluramine, insulin, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenylbutazone, probenecid, quinolones, (eg, ciprofloxacin), salicylates (eg, aspirin), sulfonamides (eg, sulfamethoxazole), or thiazolidinediones (eg, pioglitazone) because the risk of low blood sugar may be increased
  • Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone) diazoxide, diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), isoniazid, nicotinic acid, phenothiazines (eg, chlorpromazine), phenytoin, rifampin, sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because they may decrease Glyburide/Metformin 's effectiveness, resulting in high blood sugar
  • Gemfibrozil because blood sugar may be increased or decreased
  • Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin because they may increase the risk of Glyburide/Metformin 's side effects

This may not be a complete list of all interactions that may occur. Ask your health care provider if Glyburide/Metformin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Glyburide/Metformin :

Use Glyburide/Metformin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Glyburide/Metformin . Talk to your pharmacist if you have questions about this information.
  • Take Glyburide/Metformin by mouth with meals.
  • High amounts of dietary fiber may decrease Glyburide/Metformin 's effectiveness, resulting in high blood sugar. If you have questions about including fiber in your diet while you are taking Glyburide/Metformin , talk with your doctor.
  • Take Glyburide/Metformin on a regular schedule to get the most benefit from it. Taking Glyburide/Metformin at the same time each day will help you remember to take it.
  • Continue to take Glyburide/Metformin even if you feel well. Do not miss any doses.
  • If you miss a dose of Glyburide/Metformin , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Glyburide/Metformin .

Important safety information:

  • Dizziness may occur while you are using Glyburide/Metformin . This effect may be worse if you take it with alcohol or certain medicines. Use Glyburide/Metformin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Follow the diet and exercise program given to you by your health care provider.
  • Do NOT take more than the recommended dose without checking with your doctor.
  • Do not drink large amounts of alcohol while you use Glyburide/Metformin . Alcohol may increase the risk of Glyburide/Metformin 's side effects. Also, alcohol may rarely interact with Glyburide/Metformin and cause a serious reaction with symptoms such as flushing, nausea, vomiting, dizziness, or stomach pain. Talk with your doctor or health care provider before you drink alcohol while you use Glyburide/Metformin .
  • Tell your doctor or dentist that you take Glyburide/Metformin before you receive any medical or dental care, emergency care, or surgery.
  • Be careful not to become dehydrated, especially during hot weather, while you are being active, or if you have vomiting or diarrhea. Dehydration may increase your risk of side effects from Glyburide/Metformin .
  • Glyburide/Metformin contains a sulfonylurea. It may increase the risk of death from heart disease. Talk with your doctor about the benefits and risks of this or other therapies to treat your condition.
  • Carry an ID card at all times that says you have diabetes. Check your blood sugar levels as directed by your doctor. If they are often higher than they should be and you take Glyburide/Metformin exactly as prescribed, tell your doctor.
  • Glyburide/Metformin may lower your blood sugar levels. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your heart beat faster; make your vision change; give you a headache, chills, or tremors; or make you more hungry. It is a good idea to carry a reliable source of glucose (eg, tablets or gel) to treat low blood sugar. If this is not available, you should eat or drink a quick source of sugar like table sugar, honey, candy, orange juice, or non-diet soda. This will raise your blood sugar level quickly. Tell your doctor right away if this happens. To prevent low blood sugar, eat meals at the same time each day and do not skip meals.
  • Risk of low blood sugar may be increased by heavy or prolonged exercise, drinking alcohol, or skipping meals.
  • Fever, infection, injury, or surgery may increase your risk for high or low blood sugar levels. If any of these occur, check your blood sugar closely and tell your doctor right away.
  • Glyburide/Metformin may commonly cause stomach upset, indigestion, nausea, vomiting, or diarrhea at the beginning of treatment. If you develop unusual or unexpected stomach problems, or if you develop stomach problems later during treatment, contact your doctor at once. This may be a sign of lactic acidosis.
  • Lab tests, including kidney function, fasting blood glucose, hemoglobin A1c, and blood counts, may be performed while you use Glyburide/Metformin . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Glyburide/Metformin with caution in the ELDERLY; they may be more sensitive to its effects. Low blood sugar levels may also be more difficult to recognize in the elderly.
  • Glyburide/Metformin should not be used in CHILDREN younger than 9 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Glyburide/Metformin while you are pregnant. Glyburide/Metformin should not be used for at least 2 weeks before the expected delivery date because it may cause low blood sugar in the baby. It is not known if Glyburide/Metformin is found in breast milk.

Possible side effects of Glyburide/Metformin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; headache; indigestion; mild stomach pain; nausea; stomach upset; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain or discomfort; confusion; dark urine; dizziness or lightheadedness; fainting; fast or difficult breathing; feeling of being unusually cold; fever, chills, or persistent sore throat; general feeling or being unwell; low blood sugar symptoms (eg, anxiety, dizziness, fast heartbeat, headache, tremors, unusual sweating); muscle pain or weakness; severe or persistent blurred vision or other vision problems; slow or irregular heartbeat; unusual bruising or bleeding; unusual drowsiness; unusual or persistent stomach pain or discomfort; unusual tiredness or weakness; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include coma; confusion; dizziness or lightheadedness; fainting; fast or difficult breathing; fast, slow, or irregular heartbeat; feeling of being unusually cold; general feeling of being unwell; muscle pain or tenderness; seizures; tremor; unusual drowsiness; unusual stomach discomfort; unusual weakness or tiredness.

Proper storage of Glyburide/Metformin :

Store Glyburide/Metformin at 77 degrees F (25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Glyburide/Metformin out of the reach of children and away from pets.

General information:

  • If you have any questions about Glyburide/Metformin , please talk with your doctor, pharmacist, or other health care provider.
  • Glyburide/Metformin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Glyburide/Metformin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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