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All about: Granisetron Tablets

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Generic Name: Granisetron Tablets (gra-NI-se-tron)
Brand Name: Kytril

Granisetron is used for:

Preventing nausea and vomiting caused by cancer chemotherapy and radiation. It may also be used for other conditions as determined by your doctor.

Granisetron is 5-HT3 receptor antagonist. It works by blocking a chemical called serotonin that can cause vomiting.

Do NOT use Granisetron if:

  • you are allergic to any ingredient in Granisetron
  • you are taking apomorphine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Granisetron:

Some medical conditions may interact with Granisetron. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to other 5-HT3 receptor antagonists (eg, ondansetron)

Some MEDICINES MAY INTERACT with Granisetron. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Apomorphine because the risk of side effects, such as severely low blood pressure or loss of consciousness, may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Granisetron may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Granisetron:

Use Granisetron as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Granisetron may be taken with or without food.
  • Use Granisetron only on the days that you receive your cancer treatment, unless otherwise directed by your doctor.
  • If you miss a dose of Granisetron, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Granisetron.

Important safety information:

  • Granisetron may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Granisetron. Using Granisetron alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Use Granisetron with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Granisetron during pregnancy. It is unknown if Granisetron is excreted in breast milk. If you are or will be breast-feeding while you are using Granisetron, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Granisetron:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Agitation; anxiety; constipation; diarrhea; dizziness; drowsiness; headache; indigestion; nausea; stomach pain; taste changes; trouble sleeping; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; fainting; fast or irregular heartbeat; fever, chills, or sore throat; unusual muscle movement.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Granisetron:

Store Granisetron at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Granisetron out of the reach of children and away from pets.

General information:

  • If you have any questions about Granisetron, please talk with your doctor, pharmacist, or other health care provider.
  • Granisetron is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Granisetron. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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