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All about: Guaifenesin/Phenylephrine Controlled-Release Tablets

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Generic Name: Guaifenesin/Phenylephrine Controlled-Release Tablets (gwye-FEN-e-sin/fen-il-EF-rin)
Brand Name: Examples include Lusonex and Miraphen PE

Guaifenesin/Phenylephrine Controlled-Release Tablets is used for:

Relieving symptoms of congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Guaifenesin/Phenylephrine Controlled-Release Tablets is a decongestant and expectorant combination. It works by constricting blood vessels and shrinking swollen and congested nasal tissues (mucous membranes) and by thinning and loosening mucus in the airway. This allows you to breathe more easily and makes coughs more productive.

Do NOT use Guaifenesin/Phenylephrine Controlled-Release Tablets if:

  • you are allergic to any ingredient in Guaifenesin/Phenylephrine Controlled-Release Tablets
  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems
  • you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Guaifenesin/Phenylephrine Controlled-Release Tablets:

Some medical conditions may interact with Guaifenesin/Phenylephrine Controlled-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a fast, slow, or irregular heartbeat
  • if you have a history of adrenal gland problems (eg, tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, an enlarged prostate, seizures, or an overactive thyroid
  • if you have chronic cough

Some MEDICINES MAY INTERACT with Guaifenesin/Phenylephrine Controlled-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Guaifenesin/Phenylephrine Controlled-Release Tablets's side effects
  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Bromocriptine because the risk of its side effects may be increased by Guaifenesin/Phenylephrine Controlled-Release Tablets
  • Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Guaifenesin/Phenylephrine Controlled-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Guaifenesin/Phenylephrine Controlled-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Guaifenesin/Phenylephrine Controlled-Release Tablets:

Use Guaifenesin/Phenylephrine Controlled-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Guaifenesin/Phenylephrine Controlled-Release Tablets by mouth with or without food.
  • Take Guaifenesin/Phenylephrine Controlled-Release Tablets with a full glass of water (8 oz/240 mL) unless your doctor directs otherwise.
  • Swallow Guaifenesin/Phenylephrine Controlled-Release Tablets whole. Do not break, crush, or chew before swallowing. Some brands of Guaifenesin/Phenylephrine Controlled-Release Tablets may be broken in half before taking. If you have difficulty swallowing the whole tablet, ask your pharmacist if your brand of medicine may be broken in half.
  • If you miss a dose of this medicine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Guaifenesin/Phenylephrine Controlled-Release Tablets.

Important safety information:

  • Guaifenesin/Phenylephrine Controlled-Release Tablets may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Guaifenesin/Phenylephrine Controlled-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not take diet or appetite control medicines while you are taking Guaifenesin/Phenylephrine Controlled-Release Tablets without checking with you doctor.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.
  • Guaifenesin/Phenylephrine Controlled-Release Tablets may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Guaifenesin/Phenylephrine Controlled-Release Tablets.
  • Tell your doctor or dentist that you take Guaifenesin/Phenylephrine Controlled-Release Tablets before you receive any medical or dental care, emergency care, or surgery.
  • Use Guaifenesin/Phenylephrine Controlled-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects.
  • Caution is advised when using Guaifenesin/Phenylephrine Controlled-Release Tablets in CHILDREN; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Guaifenesin/Phenylephrine Controlled-Release Tablets while you are pregnant. It is not known if Guaifenesin/Phenylephrine Controlled-Release Tablets is found in breast milk. Do not breast-feed while taking Guaifenesin/Phenylephrine Controlled-Release Tablets.

Possible side effects of Guaifenesin/Phenylephrine Controlled-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Guaifenesin/Phenylephrine Controlled-Release Tablets:

Store Guaifenesin/Phenylephrine Controlled-Release Tablets at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Guaifenesin/Phenylephrine Controlled-Release Tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about Guaifenesin/Phenylephrine Controlled-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Guaifenesin/Phenylephrine Controlled-Release Tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Guaifenesin/Phenylephrine Controlled-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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