24 . August , 2019 - Saturday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: guanadrel

Big Image

Generic Name: guanadrel (GWAH na drel)
Brand Names: Hylorel

What is guanadrel?

Guanadrel lowers blood pressure by decreasing the levels of certain chemicals in the blood. This allows the blood vessels (veins and arteries) to relax (widen).

Guanadrel is used to treat hypertension (high blood pressure).

Guanadrel may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about guanadrel?

Do not stop taking guanadrel suddenly without first talking to your doctor. This could cause severely high blood pressure, nervousness, and anxiety. Use caution when driving, operating machinery, or performing other hazardous activities. Guanadrel may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use caution when rising from a sitting or lying position, especially first thing in the morning. Dizziness may occur while taking guanadrel and may result in a fall.

What should I discuss with my healthcare provider before taking guanadrel?

Do not take guanadrel without first talking to your doctor if you
  • have congestive heart failure;

  • have pheochromocytoma; or

  • are taking a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate).

Before taking this medication, tell your doctor if you have

  • peptic ulcer disease (stomach ulcers);

  • ulcerative colitis;

  • kidney disease; or
  • asthma.

You may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Guanadrel is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not take guanadrel without first talking to your doctor if you are pregnant or could become pregnant during treatment. Guanadrel passes into breast milk and it may be harmful to a nursing infant. Do not take guanadrel without first talking to your doctor if you are breast-feeding a baby.

How should I take guanadrel?

Take guanadrel exactly as directed. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Take guanadrel with food or milk if it causes stomach upset.

It is important to take guanadrel regularly to get the most benefit.

Do not stop taking guanadrel suddenly without first talking to your doctor. This could cause severely high blood pressure, nervousness, and anxiety.

Your doctor may want you to have blood pressure monitoring or other medical evaluations during treatment with guanadrel to monitor progress and side effects.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected.

Symptoms of a guanadrel overdose include low blood pressure (fainting, dizziness, weakness); a slow pulse; low body temperature; diarrhea; and slow breathing.

What should I avoid while taking guanadrel?

Use caution when driving, operating machinery, or performing other hazardous activities. Guanadrel may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use caution when rising from a sitting or lying position, especially first thing in the morning. Dizziness may occur while taking guanadrel and may result in a fall.

Avoid alcohol while taking guanadrel. It may increase drowsiness an dizziness caused by guanadrel. Use caution even with small amounts of alcohol.

Guanadrel may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if guanadrel is taken with any of these medications. Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor.

Avoid becoming overheated in hot weather or during exercise. Also avoid standing for long periods of time and use caution if you have a fever. These situations increase the effects of guanadrel in the body and may cause dizziness.

Before having surgery, tell your doctor or dentist that you are taking this medication.

Guanadrel side effects

If you experience any of the following serious side effects, stop taking guanadrel and seek emergency medical attention or contact your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  • irregular heartbeats;

  • heart failure (shortness of breath, swelling of ankles or legs, sudden weight gain of 5 pounds or more); or

  • chest pain.

Other, less serious side effects are more likely to occur. Continue to take guanadrel and talk to your doctor if you experience

  • unusual fatigue or drowsiness;

  • dizziness (avoid standing up to quickly and use caution when performing hazardous activities);

  • anxiety, depression, or nightmares;

  • diarrhea, nausea, or vomiting (take guanadrel with food or milk if it upsets your stomach);

  • a stuffy nose or a dry mouth (sucking on ice chips or sugarless hard candy may relieve a dry mouth);

  • blurred vision;

  • weight gain; or

  • impotence or difficulty ejaculating.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect guanadrel?

Do not take guanadrel without first talking to your doctor if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days

Before taking guanadrel, tell your doctor if you are taking any of the following medicines:

  • a respiratory medicine such as albuterol (Ventolin, Proventil, Volmax, others), pirbuterol (Maxair), salmeterol (Serevent), and others;

  • a beta-blocker such as atenolol (Tenormin), acebutolol (Sectral), bisoprolol (Zebeta), carteolol (Cartrol), carvedilol (Coreg), labetalol (Trandate, Normodyne), metoprolol (Lopressor), nadolol (Corgard), propranolol (Inderal), pindolol (Visken), and timolol (Blocadren);

  • a phenothiazine such as chlorpromazine (Thorazine), prochlorperazine (Compazine), perphenazine (Trilafon), fluphenazine (Prolixin), thioridazine (Mellaril), and others;

  • other heart medications such as hydralazine (Apresoline) or minoxidil (Loniten); or

  • a tricyclic antidepressant such as amitriptyline (Elavil, Endep), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor), and others.

You may require special monitoring or a dosage adjustment if you are taking any of the medicines listed above.

Guanadrel may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine without first talking to your doctor.

Drugs other than those listed here may also interact with guanadrel or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

  • Your pharmacist has additional information about guanadrel written for health professionals that you may read.

What does my medication look like?

Guanadrel is available with a prescription under the brand name Hylorel. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Hylorel 10 mg--light-orange, elliptical, scored tablets

  • Hylorel 25 mg--white, elliptical, scored tablets

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 6.02. Revision Date: 2/13/04 4:00:59 PM.

Recent Drug Updates at DrugIndexOnline:





AK-Tate Ophthalmic AK-Tate Ophthalmic
Some commonly used brand names are: In the U.S.— AK-Dex 2 AK-Pred 6 AK-Tate 6 Baldex 2 Decadron 2 Dexair 2 Dexotic 2 Econopred 6 Econopred Plus 6 Eflone 3 Flarex 3 Fluor-Op 3 FML Forte 3 FML Liquifilm 3 FML S.O.P. 3 HMS Liquifilm 5 Inflamase Forte 6 Inflamase Mild 6 I-Pred 6 Lite Pred 6 M more...

Combunox Combunox
Some commonly used brand names are: In the U.S.— Combunox † Not commercially available in Canada. Category Analgesic Description Ibuprofen and oxycodone (eye-byoo-PROE-fen and ox-i-KOE-done) combination is used to relieve pain. Ibuprofen is a nonsteroidal anti-inflammatory more...

echothiophate iodide ophthalmic echothiophate iodide ophthalmic
Generic Name: echothiophate iodide ophthalmic (eck oh THYE oh fate EYE oh dide) Brand Names: Phospholine Iodide What is echothiophate iodide ophthalmic? Echothiophate iodide ophthalmic reduces pressure in the eye by increasing the amount of fluid that drains from the eye. Echothiophate i more...

Etidocaine Parenteral-Local Etidocaine Parenteral-Local
Some commonly used brand names are: In the U.S.— Carbocaine 7 Carbocaine with Neo-Cobefrin 7 Chirocaine 5 Citanest Forte 8 Citanest Plain 8 Dalcaine 6 Dilocaine 6 Duranest 4 Duranest-MPF 4 Isocaine 7 L-Caine 6 Lidoject-1 6 Lidoject-2 6 Marcaine 2 Marcaine Spinal 2 Nesacaine 3 Nesacaine-MP more...

Fentora buccal Fentora buccal
Generic Name: fentanyl (buccal) (FEN ta nil (BUK al)) Brand Names: Fentora What is fentanyl buccal? Fentanyl is a narcotic (opioid) pain medicine. Fentanyl buccal tablets are used to treat "breakthrough" cancer pain that is not controlled by other medicines. Fentanyl buccal may also be more...

Flurbiprofen Flurbiprofen
Some commonly used brand names are: In the U.S.— Actron 9 Advil 7 Advil Caplets 7 Advil, Children's 7 Aleve 14 Anaprox 14 Anaprox DS 14 Ansaid 6 Bayer Select Ibuprofen Pain Relief Formula Caplets 7 Cataflam 1 Clinoril 18 Cotylbutazone 16 Cramp End 7 Daypro 15 Dolgesic 7 Dolobid 2 EC-Napro more...

Neomycin, Polymyxin B, Hydrocortisone Ophthalmic Suspension Neomycin, Polymyxin B, Hydrocortisone Ophthalmic Suspension
Generic Name: neomycin sulfate, polymyxin B sulfate and hydrocortisone) Dosage Form: Ohthalmic suspension, DESCRIPTION Neomycin and Polymyxin B Sulfates and Hydrocortisone Ophthalmic Suspension is a sterile antimicrobial and anti-inflammatory suspension for ophthalmic use. Each mL contains: Acti more...

Pitocin Pitocin
Some commonly used brand names are: In the U.S.— Pitocin Syntocinon In Canada— Syntocinon Generic name product may be available in the U.S. Category Antihemorrhagic, postabortion uterine bleeding Antihemorrhagic, postpartum uterine bleeding Diagnostic aid, placental reserve D more...