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All about: Guaphenyl LA Sustained-Release Capsules

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Generic Name: Guaifenesin/Phenylephrine Sustained-Release Capsules (gwye-FEN-e-sin/fen-il-EF-rin)
Brand Name: Examples include Entex LA and Guaphenyl LA

Guaphenyl LA Sustained-Release Capsules is used for:

Relieving congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Guaphenyl LA Sustained-Release Capsules is a decongestant and expectorant combination. It works by constricting blood vessels and shrinking swollen and congested nasal tissues (mucous membranes) and by thinning and loosening mucus in the airway. This allows you to breathe more easily and makes coughs more productive.

Do NOT use Guaphenyl LA Sustained-Release Capsules if:

  • you are allergic to any ingredient in Guaphenyl LA Sustained-Release Capsules
  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or other severe heart problems
  • you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Guaphenyl LA Sustained-Release Capsules:

Some medical conditions may interact with Guaphenyl LA Sustained-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a fast, slow, or irregular heartbeat
  • if you have a history of adrenal gland problems (eg, tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, an enlarged prostate, seizures, or an overactive thyroid
  • if you have chronic cough

Some MEDICINES MAY INTERACT with Guaphenyl LA Sustained-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAOIs (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Guaphenyl LA Sustained-Release Capsules's side effects
  • Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased
  • Bromocriptine because the risk of its side effects may be increased by Guaphenyl LA Sustained-Release Capsules
  • Guanadrel, guanethidine, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Guaphenyl LA Sustained-Release Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Guaphenyl LA Sustained-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Guaphenyl LA Sustained-Release Capsules:

Use Guaphenyl LA Sustained-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Guaphenyl LA Sustained-Release Capsules by mouth with or without food.
  • Take Guaphenyl LA Sustained-Release Capsules with a full glass of water (8 oz/240 mL) unless your doctor directs otherwise.
  • Swallow Guaphenyl LA Sustained-Release Capsules whole. Do not break, crush, or chew before swallowing.
  • If you miss a dose of Guaphenyl LA Sustained-Release Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Guaphenyl LA Sustained-Release Capsules.

Important safety information:

  • Guaphenyl LA Sustained-Release Capsules may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Guaphenyl LA Sustained-Release Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not take diet or appetite control medicines while you are taking Guaphenyl LA Sustained-Release Capsules without checking with your doctor.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.
  • Guaphenyl LA Sustained-Release Capsules may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Guaphenyl LA Sustained-Release Capsules.
  • Tell your doctor or dentist that you take Guaphenyl LA Sustained-Release Capsules before you receive any medical or dental care, emergency care, or surgery.
  • Use Guaphenyl LA Sustained-Release Capsules with caution in the ELDERLY; they may be more sensitive to its effects.
  • Caution is advised when using Guaphenyl LA Sustained-Release Capsules in CHILDREN; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Guaphenyl LA Sustained-Release Capsules while you are pregnant. It is not known if Guaphenyl LA Sustained-Release Capsules is found in breast milk. Do not breast-feed while taking Guaphenyl LA Sustained-Release Capsules.

Possible side effects of Guaphenyl LA Sustained-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Guaphenyl LA Sustained-Release Capsules:

Store Guaphenyl LA Sustained-Release Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Guaphenyl LA Sustained-Release Capsules out of the reach of children and away from pets.

General information:

  • If you have any questions about Guaphenyl LA Sustained-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.
  • Guaphenyl LA Sustained-Release Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Guaphenyl LA Sustained-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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