19 . January , 2018 - Friday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Haemophilus b Conjugate Vaccine

Big Image Pronouncation: (hem-AHF-ill-us)
Class: Vaccine, bacterial

Trade Names:
ActHIB
- Powder for Injection, lyophilized 10 mcg purified capsular polysaccharide, 24 mcg tetanus toxoid/0.5 mL

Trade Names:
Comvax
- Injection 7.5 mcg Haemophilus b PRP purified capsular polysaccharide, 125 mcg Neisseria meningitidis OMPC, 5 mcg hepatitis B surface antigen, about 225 mcg aluminum, and 35 mcg sodium borate/0.5 mL

Trade Names:
HibTITER
- Injection 10 mcg purified Haemophilus b saccharide capsular oligosaccharide, about 25 mcg diphtheria CRM 197 protein/0.5 mL dose

Trade Names:
PedvaxHIB, Liquid
- Injection 7.5 mcg Haemophilus b PRP, 125 mcg Neisseria meningitidis OMPC, and 225 mcg aluminum/0.5 mL

Mechanism of Action

Pharmacology

Induces specific protective antibodies against Haemophilus influenzae type b (Hib).

Indications and Usage

Induction of active immunity against Hib infection. Routine immunization of all infants beginning at age 2 mo is recommended.

Contraindications

Hypersensitivity to any product component (some products contain thimerosal).

Dosage and Administration

HibTITER
Pediatric

IM Beginning at 2 mo of age, give 3 doses, 2 mo apart, plus a booster dose at 15 mo.

ActHIB
Pediatric

IM Beginning at 2 mo of age, give 3 doses, 2 mo apart, plus a booster dose at 15 to 18 mo.

PedvaxHIB
Pediatric

IM Beginning at 2 mo of age, give 2 doses, 2 mo apart, plus a booster dose at 12 mo.

General Advice

  • Administer IM in outer aspect of vastus lateralis, midthigh, or outer aspect of upper arm. Do not inject in gluteal area or near major nerve trunk.
  • Do not inject via IV route.
  • May be given simultaneously with DTP, MMR, OPV, or IPV.

Storage/Stability

Store vials in refrigerator (36° to 46°F). Do not freeze.

Drug Interactions

None well documented.

Laboratory Test Interactions

Diagnostic value of antigen detection (eg, with latex agglutination kits) may be diminished in suspected Hib disease within few days to 2 wk after immunization.

Adverse Reactions

CNS

Irritability; fever; restless sleep; convulsions.

Dermatologic

Rash; hives.

GI

Diarrhea; vomiting; loss of appetite.

Genitourinary

Renal failure.

Miscellaneous

Guillain-Barré syndrome; local erythema; swelling; tenderness; induration.

Precautions

Pregnancy

Category C .

Lactation

Undetermined.

Children

HibTITER and PedvaxHIB are not recommended in children younger than 6 wk of age.

Anticoagulant therapy

Administer Hib vaccine with caution to patients receiving anticoagulant therapy.

Interchange

In general, complete vaccination series begun with one brand of Hib vaccine with that brand unless specific information about interchangeability is available.

Latex allergy

Stopper for diluent vial for ActHIB contains dry natural latex rubber; HibTITER packaging contains dry natural rubber.

Patient Information

  • Advise that acetaminophen (appropriate for age) may be given every 4 h for low-grade fever. Emphasize that aspirin should not be given to children.
  • Instruct parent or guardian to report any adverse effects after vaccine administration.
  • Remind parent to keep child's immunization record up to date.

Recent Drug Updates at DrugIndexOnline:





Cascara Sagrada and Bisacodyl Cascara Sagrada and Bisacodyl
Some commonly used brand names are: In the U.S.— Agoral 35 Alophen 25 Alphamul 30 Alramucil Orange 7 Alramucil Regular 7 Bisac-Evac 25 Black-Draught 26 Black-Draught Lax-Senna 32 Carter's Little Pills 25 Cholac 14 Citroma 16 Citrucel Orange Flavor 3 Citrucel Sugar-Free Orange Flavor 3 Col more...

Cephalexin Cephalexin
Dosage Form: Tablets, capsules, oral suspension To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cephalexin capsules, Cephalexin for oral suspension, Cephalexin tablets, and other antibacterial drugs, Cephalexin capsules, Cephalexin for oral suspension, and more...

chlorphenesin chlorphenesin
Generic Name: chlorphenesin (klor FEH nah sin) Brand Names: Maolate What is chlorphenesin? Chlorphenesin is a muscle relaxant. It works by blocking nerve impulses (or pain sensations) that are sent to your brain. Chlorphenesin is used, along with rest and physical therapy, to treat injur more...

Clean & Clear Persagel 10 Topical Clean & Clear Persagel 10 Topical
Some commonly used brand names are: In the U.S.— Acne-Aid Vanishing Cream Acne-Aid Aqua Gel Ambi 10 Acne Medication Benoxyl 5 Lotion Benoxyl 10 Lotion Benzac AC 21/2 Gel Benzac AC 5 Gel Benzac AC 10 Gel Benzac AC Wash 21/2 Benzac AC Wash 5 Benzac AC Wash 10 Benzac 5 Gel Benzac 10 Gel Benz more...

Dallergy-JR Dallergy-JR
Generic Name: chlorpheniramine and phenylephrine (klor feh NEER a meen and fen il EFF rin) Brand Names: Chlor-Mes Jr, Dallergy-JR, Histatab Plus, Rondec, Rynatan What is Dallergy-JR (chlorpheniramine and phenylephrine)? Chlorpheniramine is an antihistamine that reduces the natural chemi more...

Fluocinolone Solution Fluocinolone Solution
Generic Name: fluocinolone acetonide Dosage Form: Topical solution usp, 0.01% FOR DERMATOLOGIC USE ONLY NOT FOR OPHTHALMIC USE Rx only Fluocinolone Solution Description Fluocinolone Acetonide Topical Solution USP, 0.01% contains fluocinolone acetonide USP (Pregna-1,4-diene-3,20-dione, 6,9-difluo more...

Novo-Medrone Novo-Medrone
Some commonly used brand names are: In the U.S.— Amen 3 Aygestin 5 Crinone 6 Curretab 3 Cycrin 3 Depo-Provera 3 depo-subQ provera 104 3 Gesterol 50 6 Gesterol LA 250 1 Hy/Gestrone 1 Hylutin 1 Megace 4 Prochieve 6 Prodrox 1 Prometrium 6 Pro-Span 1 Provera 3 In Canada— Alti-MPA 3 Ap more...

Postacne Topical Postacne Topical
Some commonly used brand names are: In the U.S.— Acne Lotion 10 Liquimat Light Liquimat Medium In Canada— Postacne Category Antiacne agent, topical Cleansing agent, astringent-keratolytic Cleansing agent, defatting-keratolytic Description Alcohol and sulfur (AL-koe-hol an more...