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All about: Haemophilus b Conjugate Vaccine (HbOC—Diphtheria CRM 197 Protein Conjugate)

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Some commonly used brand names are:

In the U.S.—

  • Act-Hib 4
  • Hibtiter 1
  • Pedvaxhib 3
  • Prohibit 2

In Canada—

  • Act-Hib 4
  • Hibtiter 1
  • Pedvaxhib 3
  • Prohibit 2

Other commonly used names are: HbOC , PRP-D , PRP-OMP , and PRP-T .

This information applies to the following medicines:
1. Haemophilus b Conjugate Vaccine (HbOC—DiphtheriaCRM 197 Protein Conjugate)§
2. Haemophilus b Conjugate Vaccine (PRP-D—DiphtheriaToxoid Conjugate)§
3. Haemophilusb Conjugate Vaccine (PRP-OMP—Meningococcal Protein Conjugate)§
4. Haemophilus b Conjugate Vaccine (PRP-T—TetanusProtein Conjugate)§
‡ Generic name product may be available in the U.S.
§ Generic name product may be available in Canada

Category

  • Immunizing agent, active

Description

Haemophilus b conjugate (hem-OFF-fil-us BEE KON-ja-gat) vaccine is an active immunizing agent used to prevent infection by Haemophilus influenza type b (Hib) bacteria. The vaccine works by causing your body to produce its own protection (antibodies) against the disease.

Haemophilus b conjugate vaccine is an haemophilus b vaccine that has been prepared by adding a diphtheria-, meningococcal-, or tetanus-related substance. However, this vaccine does not take the place of the regular diphtheria or tetanus toxoid injections (for example, DTP, DT, or T) that children should receive, the regular tetanus toxoid or diphtheria and tetanus toxoid injections (for example T or Td) that adults should receive, or the meningococcal vaccine injection that some children and adults should receive.

Infection by Haemophilus influenza type b (Hib) bacteria can cause life-threatening illnesses, such as meningitis, which affects the brain; epiglottitis, which can cause death by suffocation; pericarditis, which affects the heart; pneumonia, which affects the lungs; and septic arthritis, which affects the bones and joints. Hib meningitis causes death in 5 to 10% of children who are infected. Also, approximately 30% of children who survive Hib meningitis are left with some type of serious permanent damage, such as mental retardation, deafness, epilepsy, or partial blindness.

Immunization against Hib is recommended for all children 2 months up to 5 years of age (i.e., up to the 5th birthday).

Immunization against Hib may also be recommended for adults and children over 5 years of age with certain medical problems.

This vaccine is to be administered only by or under the supervision of your doctor or other authorized health care professional. It is available in the following dosage form:

  • Parenteral
  • Injection (U.S. and Canada)

Before Receiving This Vaccine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For haemophilus b conjugate vaccine, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to haemophilus b conjugate vaccine, haemophilus b polysaccharide vaccine, diphtheria or tetanus toxoid, or meningococcal vaccine. Also tell your health care professional if you are allergic to any other substances, such as preservatives.

Pregnancy—Studies on effects in pregnancy have not been done in either humans or animals.

Breast-feeding—This vaccine has not been reported to cause problems in nursing babies.

Children—This vaccine is not recommended for children less than 2 months of age.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of this vaccine in the elderly with use in other age groups, this vaccine is not expected to cause different side effects or problems in older people than it does in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems—The presence of other medical problems may affect the use of haemophilus b conjugate vaccine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Fever or
  • Serious illness—The symptoms of the condition may be confused with some of the possible side effects of the vaccine

Proper Use of This Vaccine

Dosing—Haemophilus b conjugate vaccine is an haemophilus b vaccine that has been prepared by adding a diphtheria-, meningococcal-, or tetanus-related substance to it. If the vaccine was prepared using a diphtheria-related substance, it is called either HbOC or PRP-D. If the vaccine was prepared using a meningococcal-related substance, it is called PRP-OMP. If the vaccine was prepared using a tetanus-related substance, it is called PRP-T. All of these subtypes of haemophilus b conjugate vaccine work the same way , but may be given at different ages or times.

The dose of haemophilus b conjugate vaccine will be different for different patients. The following information includes only the average doses of haemophilus b conjugate vaccine.

  • For prevention of Haemophilus influenzae type b infection:
    • For HbOC or PRP-T injection dosage form:
      • Adults and children 5 years of age and older—Use and dose must be determined by your doctor.
      • Infants 2 to 6 months of age at the first dose—Three doses, two months apart, then a booster dose at fifteen months of age. The doses are injected into a muscle.
      • Children 7 to 11 months of age at the first dose—Two doses, two months apart, then a booster dose at fifteen months of age. The doses are injected into a muscle.
      • Children 12 to 14 months of age at the first dose—One dose, then a booster dose at fifteen months of age. The doses are injected into a muscle.
      • Children 15 to 59 months of age at the first dose—One dose injected into a muscle.
    • For PRP-D injection dosage form:
      • Adults and children 5 years of age and older—Use and dose must be determined by your doctor.
      • Infants and children up to 15 months of age—Use is not recommended.
      • Children 15 to 59 months of age at the first dose—One dose injected into a muscle.
    • For PRP-OMP injection dosage form:
      • Adults and children 5 years of age and older—Use and dose must be determined by your doctor.
      • Infants 2 to 6 months of age at the first dose—Two doses, two months apart, then a booster dose at twelve months of age. The doses are injected into a muscle.
      • Children 7 to 11 months of age at the first dose—Two doses, two months apart, then a booster dose at fifteen months of age. The doses are injected into a muscle.
      • Children 12 to 14 months of age at the first dose—One dose, then a booster dose at fifteen months of age. The doses are injected into a muscle.
      • Children 15 to 59 months of age at the first dose—One dose injected into a muscle.

After Receiving This Vaccine

This vaccine may interfere with laboratory tests that check for Hib disease. Make sure your doctor knows that you have received Hib vaccine if you are treated for a severe infection during the 2 weeks after you receive this vaccine.

Side Effects of This Vaccine

Along with its needed effects, a vaccine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Get emergency help immediately if any of the following side effects occur:

Symptoms of allergic reactions

Difficulty in breathing or swallowing; hives; itching (especially of feet or hands); reddening of skin (especially around ears); swelling of eyes, face, or inside of nose; unusual tiredness or weakness (sudden and severe)

Check with your doctor immediately if the following side effect occurs:

Rare

Convulsions (seizures)

Other side effects may occur that usually do not need medical attention. However, check with your doctor if any of the following side effects continue or are bothersome:

More common

Fever of up to 102 °F (39 °C) (usually lasts less than 48 hours); irritability; loss of appetite; lack of interest; redness at place of injection; reduced physical activity; tenderness at place of injection; tiredness

Less common

Diarrhea; fever over 102 °F (39 °C) (usually lasts less than 48 hours); hard lump, swelling, or warm feeling at place of injection; skin rash; vomiting

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Revised: 08/16/2000

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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