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All about: Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine

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Generic Name: Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine (hep-ah-TY-tiss)
Brand Name: Twinrix

Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine is used for:

Preventing hepatitis A and B infections.

Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine is a vaccine. It works by stimulating the body to produce antibodies against hepatitis A and B.

Do NOT use Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine if:

  • you are allergic to any ingredient in Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine , including yeast and neomycin
  • you have had an allergic reaction to a hepatitis vaccine in the past

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine :

Some medical conditions may interact with Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a weakened immune system, a bleeding disorder (eg, decreased blood platelets), heart or lung disease, a fever, an infection, an illness, a tumor, or multiple sclerosis

Some MEDICINES MAY INTERACT with Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine . However, no specific interactions with Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine :

Use Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine is usually administered as an injection at your doctor's office, hospital, or clinic. Ask your doctor or pharmacist any questions that you may have about Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine .
  • Shake well before using a dose.
  • If you miss a dose of Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine .

Important safety information:

  • Before receiving this vaccine, tell your doctor about any illnesses you may have or if you are running a fever.
  • To prevent hepatitis infections, 3 doses of Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine are required.
  • Tell your doctor if you have ever had an allergic reaction to any previous hepatitis vaccines.
  • Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine does not protect against hepatitis C infection.
  • Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine may not prevent hepatitis A or B infection in individuals who are already infected at the time of vaccination.
  • If all 3 doses of the vaccine are given on schedule, it is believed to remain protective against hepatitis A and B for at least 15 years. If you continue to be at risk for hepatitis A and B, check with your doctor for further instructions.
  • Additional monitoring of your dose or condition may be needed if you are taking anticoagulants (eg, warfarin) or are on immunosuppressive therapy.
  • Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine is not recommended for use in CHILDREN younger than 18 years of age. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine during pregnancy. It is unknown if Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine is excreted in breast milk. If you are or will be breast-feeding while you are using Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; fatigue; fever; headache; nausea; pain, redness, or swelling at the injection site; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; fast heartbeat.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine :

Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine is usually handled and stored by a health care provider. If you are using Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine at home, store Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine as directed by your pharmacist or health care provider. Keep Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine out of the reach of children and away from pets.

General information:

  • If you have any questions about Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine , please talk with your doctor, pharmacist, or other health care provider.
  • Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hepatitis A Inactivated/Hepatitis B (Recombinant) Vaccine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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