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All about: Hyaluronidase

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Generic Name: Hyaluronidase Injection (Human) (HYE-al-ure-ON-i-dase)
Brand Name: Hylenex

Hyaluronidase is used for:

Increasing the absorption of other injected medicines or fluids. It may also be used for other conditions as determined by your doctor.

Hyaluronidase is a protein enzyme. It works by causing rapid spreading of injected fluid into the body, which increases the absorption of injected fluids.

Do NOT use Hyaluronidase if:

  • you are allergic to any ingredient in Hyaluronidase

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hyaluronidase :

Some medical conditions may interact with Hyaluronidase . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a skin infection or skin cancer

Some MEDICINES MAY INTERACT with Hyaluronidase . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Local anesthetics (eg, lidocaine) because they may increase the risk of Hyaluronidase 's side effects
  • Antihistamines (eg, diphenhydramine), certain hormones (eg, corticotropin, estrogens), cortisone, or salicylates (eg, aspirin) because they may decrease Hyaluronidase 's effectiveness
  • Benzodiazepines (eg, alprazolam), furosemide, or phenytoin because their effectiveness may be decreased by Hyaluronidase

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hyaluronidase may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hyaluronidase :

Use Hyaluronidase as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Hyaluronidase is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Hyaluronidase at home, a health care provider will teach you how to use it. Be sure you understand how to use Hyaluronidase . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Hyaluronidase if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • Hyaluronidase should not be applied directly in the eye, injected into a vein, or injected into skin that is infected, red, swollen, or irritated.
  • If you miss a dose of Hyaluronidase , contact your doctor right away.

Ask your health care provider any questions you may have about how to use Hyaluronidase .

Important safety information:

  • Hyaluronidase should not be used to enhance absorption of dopamine or alpha agonist medicines (eg, clonidine) or to reduce the swelling of bites or stings.
  • Caution is advised when using Hyaluronidase in CHILDREN; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: It is not known if Hyaluronidase can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hyaluronidase while you are pregnant. It is not known if Hyaluronidase is found in breast milk. If you are or will be breast-feeding while you use Hyaluronidase , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Hyaluronidase :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Redness or pain at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); swelling at the injection site.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include chills; dizziness; fainting; fast heartbeat; hives; nausea; rash; redness; swelling; vomiting.

Proper storage of Hyaluronidase :

Hyaluronidase is usually handled and stored by a health care provider. If you are using Hyaluronidase at home, store Hyaluronidase as directed by your pharmacist or health care provider. Keep Hyaluronidase out of the reach of children and away from pets.

General information:

  • If you have any questions about Hyaluronidase , please talk with your doctor, pharmacist, or other health care provider.
  • Hyaluronidase is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hyaluronidase . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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