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All about: Hydrochlorothiazide/Propranolol

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Generic Name: Hydrochlorothiazide/Propranolol (HYE-droe-KLOR-oh-THYE-a-zide/proe-PRAN-oh-lole)
Brand Name: Inderide

Do not suddenly stop taking Hydrochlorothiazide/Propranolol without talking with your doctor. If Hydrochlorothiazide/Propranolol needs to be stopped by your doctor, this will be done gradually. The risk of side effects, including chest pain (eg, angina) and heart attack, may be increased if Hydrochlorothiazide/Propranolol is suddenly stopped.


Hydrochlorothiazide/Propranolol is used for:

Treating high blood pressure.

Hydrochlorothiazide/Propranolol is a beta-blocker and diuretic combination. It works by decreasing the force and slowing down the heartbeat, helping the heart beat more regularly and reducing the amount of work the heart has to do. It also increases the elimination of excess fluid, which helps to decrease blood pressure.

Do NOT use Hydrochlorothiazide/Propranolol if:

  • you are allergic to any ingredient in Hydrochlorothiazide/Propranolol or to sulfonamide medicines (eg, sulfamethoxazole, probenecid, glyburide)
  • you have bronchial asthma, uncontrolled heart failure, heart block, a very slow heart rate, or low blood pressure
  • you are unable to urinate
  • you are taking another beta-blocker (eg, propranolol), dofetilide, or mibefradil

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hydrochlorothiazide/Propranolol :

Some medical conditions may interact with Hydrochlorothiazide/Propranolol . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of asthma, bronchitis, lung disease (eg, chronic obstructive pulmonary disease), diabetes, gout, an overactive thyroid, low blood levels of potassium or sodium, heart problems (eg, congestive heart failure), blood vessel problems, pheochromocytoma, lupus, liver disease, or kidney problems
  • if you are having surgery or receiving anesthesia

Some MEDICINES MAY INTERACT with Hydrochlorothiazide/Propranolol . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Barbiturates (eg, phenobarbital), cimetidine, clonidine, corticosteroids (eg, prednisone), guanethidine, other beta-blockers (eg, propranolol), or reserpine because they may increase the risk of Hydrochlorothiazide/Propranolol 's side effects
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), phenytoin, or rifampin because they may decrease this medicine's effectiveness
  • Antiarrhythmics (eg, disopyramide), calcium channel blockers (eg, verapamil, diltiazem), or cimetidine because side effects, such as slow or irregular heart beat or low blood pressure, may occur
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), barbiturates (eg, phenobarbital), chlorpromazine, clonidine, diazoxide, flecainide, mefloquine, mibefradil, narcotics (eg, codeine), or nifedipine because their actions and the risk of their side effects, as well Hydrochlorothiazide/Propranolol 's actions and the risk of Hydrochlorothiazide/Propranolol 's side effects, may be increased
  • Allopurinol, amantadine, digitalis (eg, digoxin), dofetilide, insulin, ketanserin, lithium, other medicines for diabetes (eg, glyburide), theophylline, or thyroxine because their actions and the risk of their side effects may be increased by Hydrochlorothiazide/Propranolol

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hydrochlorothiazide/Propranolol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hydrochlorothiazide/Propranolol :

Use Hydrochlorothiazide/Propranolol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Hydrochlorothiazide/Propranolol by mouth with or without food.
  • If you also take cholestyramine or colestipol, do not take them within 1 hour before or 2 hours after taking Hydrochlorothiazide/Propranolol . Check with your doctor if you have questions.
  • Hydrochlorothiazide/Propranolol may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of Hydrochlorothiazide/Propranolol , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hydrochlorothiazide/Propranolol .

Important safety information:

  • Hydrochlorothiazide/Propranolol may cause dizziness, drowsiness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hydrochlorothiazide/Propranolol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Hydrochlorothiazide/Propranolol may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Check with your doctor before drinking alcohol while you are taking Hydrochlorothiazide/Propranolol .
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • If you suddenly stop taking certain medicines, sharp chest pain, and in some cases heart attack, may occur. When stopping treatment with Hydrochlorothiazide/Propranolol , your doctor will need to slowly decrease your dose over a period of 1 to 2 weeks and will watch you closely for side effects, particularly if you have certain kinds of heart disease. If chest pain becomes more severe, contact your doctor immediately. Because heart artery disease is common and you may no know you have it, it may be safer not to stop Hydrochlorothiazide/Propranolol quickly, even if you are only being treated for high blood pressure.
  • Hydrochlorothiazide/Propranolol may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Hydrochlorothiazide/Propranolol . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Hydrochlorothiazide/Propranolol before you receive any medical or dental care, emergency care, or surgery.
  • If you have high blood pressure, do not use nonprescription products that contain stimulants. These products may include diet pills or cold medicines. Contact your doctor if you have any questions or concerns.
  • Diabetes patients - Hydrochlorothiazide/Propranolol may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Lab tests, including blood pressure, may be performed while you use Hydrochlorothiazide/Propranolol . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Hydrochlorothiazide/Propranolol with caution in the ELDERLY; they may be more sensitive to its effects.
  • Hydrochlorothiazide/Propranolol should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hydrochlorothiazide/Propranolol while you are pregnant. Hydrochlorothiazide/Propranolol is found in breast milk. If you are or will be breast-feeding while you use Hydrochlorothiazide/Propranolol , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Hydrochlorothiazide/Propranolol :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Cough; dizziness; drowsiness; lightheadedness; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; dry mouth; irregular heartbeat; muscle pain or weakness; nausea; swelling of ankles or feet; unusual thirst or fatigue; unusually slow or irregular heartbeat; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include coughing; dizziness; drowsiness; fainting; loss of consciousness; low blood pressure; muscular weakness; nausea; seizures; slow heart rate; trouble breathing; upset stomach; vomiting; weakness.

Proper storage of Hydrochlorothiazide/Propranolol :

Store Hydrochlorothiazide/Propranolol at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hydrochlorothiazide/Propranolol out of the reach of children and away from pets.

General information:

  • If you have any questions about Hydrochlorothiazide/Propranolol , please talk with your doctor, pharmacist, or other health care provider.
  • Hydrochlorothiazide/Propranolol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hydrochlorothiazide/Propranolol . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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