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All about: Hydrocodone/Potassium Guaiacolsulfonate Liquid

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Generic Name: Hydrocodone/Potassium Guaiacolsulfonate Liquid and Syrup (hye-droe-KOE-done/poe-TASS-ee-um gwye-a-kole-SUL-foe-nate)
Brand Name: Examples include Entuss and Mintuss NX

Hydrocodone/Potassium Guaiacolsulfonate Liquid is used for:

Relieving cough and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

Hydrocodone/Potassium Guaiacolsulfonate Liquid is a cough suppressant and expectorant combination. It works by loosening mucus and lung secretions in the chest, and making coughs more productive. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use Hydrocodone/Potassium Guaiacolsulfonate Liquid if:

  • you are allergic to any ingredient in Hydrocodone/Potassium Guaiacolsulfonate Liquid or any other codeine or morphine-related medicine (eg, oxycodone)
  • you are taking sodium oxybate (GHB)
  • you have increased pressure in the brain, trouble breathing, or diarrhea due to antibiotic use

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hydrocodone/Potassium Guaiacolsulfonate Liquid:

Some medical conditions may interact with Hydrocodone/Potassium Guaiacolsulfonate Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of glaucoma, an enlarged prostate gland or other prostate problems, heart problems, diabetes, high blood pressure, blood vessel problems, stroke, adrenal gland problems, or an underactive thyroid
  • if you have a history of stomach problems, bowel problems (eg, chronic inflammation or ulceration of the bowel), or gallbladder problems (eg, gallstones), or if you have had recent abdominal surgery
  • if you have breathing or lung problems (eg, asthma, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if cough occurs with large amounts of mucus
  • if you have recently had any head injury, brain injury or tumor, infection of the brain or nervous system, epilepsy, or seizures
  • if you have a history of alcohol abuse, drug abuse, or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with Hydrocodone/Potassium Guaiacolsulfonate Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Cimetidine because it may increase the risk of Hydrocodone/Potassium Guaiacolsulfonate Liquid's side effects
  • Barbiturates (eg, phenobarbital) or sodium oxybate (GHB) because the risk of severe drowsiness or breathing problems may be increased
  • Naltrexone because it may decrease Hydrocodone/Potassium Guaiacolsulfonate Liquid's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hydrocodone/Potassium Guaiacolsulfonate Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hydrocodone/Potassium Guaiacolsulfonate Liquid:

Use Hydrocodone/Potassium Guaiacolsulfonate Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Hydrocodone/Potassium Guaiacolsulfonate Liquid by mouth with or without food.
  • Drinking extra fluids while you are taking Hydrocodone/Potassium Guaiacolsulfonate Liquid is recommended. Check with your doctor for instructions.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you miss a dose of Hydrocodone/Potassium Guaiacolsulfonate Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hydrocodone/Potassium Guaiacolsulfonate Liquid.

Important safety information:

  • Hydrocodone/Potassium Guaiacolsulfonate Liquid may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Hydrocodone/Potassium Guaiacolsulfonate Liquid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • If your symptoms do not get better within 5 to 7 days or if they get worse, check with your doctor.
  • Tell your doctor or dentist that you take Hydrocodone/Potassium Guaiacolsulfonate Liquid before you receive any medical or dental care, emergency care, or surgery.
  • Hydrocodone/Potassium Guaiacolsulfonate Liquid may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Hydrocodone/Potassium Guaiacolsulfonate Liquid.
  • Use Hydrocodone/Potassium Guaiacolsulfonate Liquid with caution in the ELDERLY; they may be more sensitive to its effects.
  • Hydrocodone/Potassium Guaiacolsulfonate Liquid should be used with extreme caution in CHILDREN younger than 6 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hydrocodone/Potassium Guaiacolsulfonate Liquid while you are pregnant. It is not known if Hydrocodone/Potassium Guaiacolsulfonate Liquid is found in breast milk. Do not breast-feed while taking Hydrocodone/Potassium Guaiacolsulfonate Liquid.

When used for long periods of time or at high doses, Hydrocodone/Potassium Guaiacolsulfonate Liquid may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Hydrocodone/Potassium Guaiacolsulfonate Liquid stops working well. Do not take more than prescribed.

When used for longer than a few weeks or at high doses, some people develop a need to continue taking Hydrocodone/Potassium Guaiacolsulfonate Liquid. This is known as DEPENDENCE or addiction.

If you suddenly stop taking Hydrocodone/Potassium Guaiacolsulfonate Liquid, you may experience WITHDRAWAL symptoms including anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Hydrocodone/Potassium Guaiacolsulfonate Liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; change in amount of urine; difficulty urinating; hearing change or loss; mental or mood changes; severe drowsiness.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Hydrocodone/Potassium Guaiacolsulfonate Liquid:

Store Hydrocodone/Potassium Guaiacolsulfonate Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hydrocodone/Potassium Guaiacolsulfonate Liquid out of the reach of children and away from pets.

General information:

  • If you have any questions about Hydrocodone/Potassium Guaiacolsulfonate Liquid, please talk with your doctor, pharmacist, or other health care provider.
  • Hydrocodone/Potassium Guaiacolsulfonate Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hydrocodone/Potassium Guaiacolsulfonate Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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