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All about: Hydrocortisone Acetate/Pramoxine Cream

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Generic Name: Hydrocortisone Acetate/Pramoxine Rectal Cream (hye-droe-KOR-ti-sone ASS-eh-tate/pra-MOX-een)
Brand Name: Analpram-HC and ProctoCream-HC

Hydrocortisone Acetate/Pramoxine Cream is used for:

Treating inflammation and itching of the anal area due to certain skin conditions.

Hydrocortisone Acetate/Pramoxine Cream is a combination topical corticosteroid and local anesthetic. It works by reducing skin inflammation (redness, swelling, itching, and irritation) in a way that is not exactly understood. It also decreases pain in the affected area.

Do NOT use Hydrocortisone Acetate/Pramoxine Cream if:

  • you are allergic to any ingredient in Hydrocortisone Acetate/Pramoxine Cream
  • you have a rectal obstruction, abscess, or perforation

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hydrocortisone Acetate/Pramoxine Cream:

Some medical conditions may interact with Hydrocortisone Acetate/Pramoxine Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have any kind of skin infection, cuts, scrapes, or lessened blood flow to your skin in the affected area
  • if you have a parasitic, bacterial, fungal, or viral infection; diabetes; diarrhea; swelling of the esophagus; stomach or intestinal problems (eg, inflammation, blockage, ulcer, perforation, fistula, colostomy); inflammation of the lining of the abdomen; measles; tuberculosis (TB); a positive TB skin test; chickenpox; shingles; herpes infection of the eye; kidney problems; or you have received a recent vaccination
  • if you have a history of congestive heart failure or heart attack
  • if you have had recent intestinal surgery or procedure

Some MEDICINES MAY INTERACT with Hydrocortisone Acetate/Pramoxine Cream. Because little, if any, of Hydrocortisone Acetate/Pramoxine Cream is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Hydrocortisone Acetate/Pramoxine Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hydrocortisone Acetate/Pramoxine Cream:

Use Hydrocortisone Acetate/Pramoxine Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Hydrocortisone Acetate/Pramoxine Cream is for use around the rectal area only.
  • Wash your hands immediately before and after using Hydrocortisone Acetate/Pramoxine Cream.
  • For use around the anus, apply a small amount of medicine to the affected area and rub in gently.
  • If you miss a dose of Hydrocortisone Acetate/Pramoxine Cream, apply it as soon as possible. If you do not remember until the next day, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Hydrocortisone Acetate/Pramoxine Cream.

Important safety information:

  • Avoid getting Hydrocortisone Acetate/Pramoxine Cream in your eyes. If you get Hydrocortisone Acetate/Pramoxine Cream in your eyes, immediately flush them with cool tap water.
  • If your symptoms do not get better within 2 to 3 weeks or if they get worse, check with your doctor.
  • Do not use Hydrocortisone Acetate/Pramoxine Cream for other rectal conditions at a later time.
  • Check with your doctor before having vaccinations while you are using Hydrocortisone Acetate/Pramoxine Cream.
  • Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Hydrocortisone Acetate/Pramoxine Cream.
  • Caution is advised when using Hydrocortisone Acetate/Pramoxine Cream in CHILDREN; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hydrocortisone Acetate/Pramoxine Cream while you are pregnant. It is not known if Hydrocortisone Acetate/Pramoxine Cream is found in breast milk after topical use. If you are or will be breast-feeding while you use Hydrocortisone Acetate/Pramoxine Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Hydrocortisone Acetate/Pramoxine Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry skin; itching.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; excessive hair growth; inflamed hair follicles; inflammation around the mouth; muscle weakness; rectal pain, burning, cracking, itching, bleeding, peeling, or irritation not present before using Hydrocortisone Acetate/Pramoxine Cream; thinning, softening, or discoloration of the skin; unusual weight gain, especially in the face.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include increased thirst or urination; muscle weakness; unusual weight gain, especially in the face. Hydrocortisone Acetate/Pramoxine Cream may be harmful if swallowed.

Proper storage of Hydrocortisone Acetate/Pramoxine Cream:

Store Hydrocortisone Acetate/Pramoxine Cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hydrocortisone Acetate/Pramoxine Cream out of the reach of children and away from pets.

General information:

  • If you have any questions about Hydrocortisone Acetate/Pramoxine Cream, please talk with your doctor, pharmacist, or other health care provider.
  • Hydrocortisone Acetate/Pramoxine Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hydrocortisone Acetate/Pramoxine Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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