21 . March , 2018 - Wednesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Hydrocortisone Acetate/Pramoxine Hydrochloride

Big Image Pronouncation: (HIGH-droe-core-tih-sone ASS-uh-TATE /pram-OX-een HIGH-droe-KLOR-ide)
Class: Corticosteroid combination

Trade Names:
- Cream 1% hydrocortisone/1% pramoxine
- Cream 2.5% hydrocortisone/1% pramoxine
- Lotion 2.5% hydrocortisone/1% pramoxine

Trade Names:
- Foam 1% hydrocortisone/1% pramoxine

Trade Names:
HC Pramoxine
- Cream 2.5% hydrocortisone/1% pramoxine

Trade Names:
- Cream 1% hydrocortisone/1% pramoxine
- Cream 2.5% hydrocortisone/1% pramoxine
- Lotion 1% hydrocortisone/1% pramoxine
- Lotion 2.5% hydrocortisone/1% pramoxine
- Ointment 1% hydrocortisone/1% pramoxine
- Ointment 2.5% hydrocortisone/1% pramoxine

Trade Names:
- Foam 1% hydrocortisone/1% pramoxine

Mechanism of Action



Depresses formation, release and activity of endogenous mediators of inflammation, as well as modifying body's immune response.


Stabilizes the neuronal membrane of nerve endings with which it comes in contact.

Indications and Usage

Topical relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.


History of hypersensitivity to any component of the product.

Dosage and Administration


Apply to the affected area as a thin film 3 or 4 times daily, depending on severity of the condition. Administration of topical corticosteroids to children should be limited to the least amount compatible with an effective therapeutic regimen.

General Advice

  • For topical use only. Not for ophthalmic or otic use.
  • Do not apply an occlusive dressing unless ordered by health care provider.


Store at controlled room temperature (59° to 86°F). Keep tube tightly closed.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions


Burning; itching; irritation; dryness; folliculitis; hypertrichosis; acneiform eruptions; hyperpigmentation; perioral dermatitis; allergic contact dermatitis; maceration of the skin; secondary infection; skin atrophy; striae; miliaria.



Category C .


Undetermined; however, systemic hydrocortisone is excreted in breast milk.


Children may demonstrate greater susceptibility to topical corticosteroids-induced hypothalamic-pituitary-adrenal (HPA) axis suppression and Cushing syndrome than mature patients because of a larger skin surface area to body weight ratio.

Topical absorption

Systemic absorption of topical corticosteroids can produce reversible HPA axis suppression, manifestations of Cushing syndrome, hyperglycemia, and glucosuria.



HPA axis suppression; manifestations of Cushing syndrome, hyperglycemia, and glucosuria, especially when large surface areas, prolonged use, or occlusive dressings are involved.

Patient Information

  • Review prescribed dosing schedule with patient or caregiver.
  • Remind patient or caregiver that cream is not to be used in the eye or ear.
  • Teach patient or caregiver proper technique for applying product: wash hands; apply thin film to affected area(s) using fingers or applicator. Wash hands after applying product.
  • Caution patient or caregiver to not cover area with an occlusive dressing unless advised by health care provider.
  • Advise patient or caregiver to contact health care provider if local redness or swelling develops or if skin lesions do not improve or worsen.

Recent Drug Updates at DrugIndexOnline:

Alendronate Alendronate
Some commonly used brand names are: In the U.S.— Fosamax In Canada— Fosamax Category Bone resorption inhibitor Description Alendronate (a-LEN-dro-nate) is used to prevent or treat osteoporosis (thinning of the bone) in women after menopause and to treat osteoporosis in me more...

Allopurinol Allopurinol
Some commonly used brand names are: In the U.S.— Aloprim Zyloprim In Canada— Apo-Allopurinol Purinol Zyloprim Generic name product may be available in the U.S. Category Antigout agent Antihyperuricemic Antiurolithic, calcium oxalate calculi Antiurolithic, uric acid calculi more...

Cramp End Cramp End
Some commonly used brand names are: In the U.S.— Actron 9 Advil 7 Advil Caplets 7 Advil, Children's 7 Aleve 14 Anaprox 14 Anaprox DS 14 Ansaid 6 Bayer Select Ibuprofen Pain Relief Formula Caplets 7 Cataflam 1 Clinoril 18 Cotylbutazone 16 Cramp End 7 Daypro 15 Dolgesic 7 Dolobid 2 EC-Napro more...

Estradiol vaginal tablets Estradiol vaginal tablets
Generic name: Estradiol vaginal tablets Brand names: Vagifem Why is Estradiol vaginal tablets prescribed? As estrogen levels decline during menopause, vaginal tissues tend to shrink and lose their elasticity--sometimes producing a condition known as atrophic vaginitis. Inserted in the vagina on more...

Estring Vaginal Estring Vaginal
Some commonly used brand names are: In the U.S.— Estrace 3 Estring 3 Premarin 1 In Canada— Estring 3 Oestrilin 4 Premarin 1 Other commonly used names are dienoestrol , oestradiol , and piperazine estrone sulfate . Note: For quick reference, the following estrogens are number more...

Nembutal Nembutal
Some commonly used brand names are: In the U.S.— Alurate 2 Amytal 1 Barbita 7 Busodium 3 Butalan 3 Butisol 3 Luminal 7 Mebaral 4 Nembutal 6 Sarisol No. 2 3 Seconal 8 Solfoton 7 Tuinal 9 In Canada— Amytal 1 Ancalixir 7 Butisol 3 Mebaral 4 Nembutal 6 Nova Rectal 6 Novopentobarb 6 No more...

Periostat Periostat
Generic Name: doxycycline hyclate Dosage Form: Tablets 20mg Periostat Description Periostat® is available as a 20 mg tablet formulation of doxycycline for oral administration. The structural formula of doxycycline hyclate is: with an empirical formula of (C22H24N2O8•HCl)2•C2H6O&b more...

Phrenilin with Caffeine and Codeine Phrenilin with Caffeine and Codeine
Generic Name: Acetaminophen/Butalbital/Caffeine/Codeine Capsules (a-SEET-a-MIN-oh-fen/bue-TAL-bi-tal/KAF-een/KOE-deen) Brand Name: Examples include Floricet with Codeine and Phrenilin with Caffeine and CodeinePhrenilin with Caffeine and Codeine is used for:Relieving tension headaches. It may a more...