21 . April , 2019 - Sunday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Hydrocortisone Acetate/Pramoxine Hydrochloride

Big Image Pronouncation: (HIGH-droe-core-tih-sone ASS-uh-TATE /pram-OX-een HIGH-droe-KLOR-ide)
Class: Corticosteroid combination

Trade Names:
Analpram-HC
- Cream 1% hydrocortisone/1% pramoxine
- Cream 2.5% hydrocortisone/1% pramoxine
- Lotion 2.5% hydrocortisone/1% pramoxine

Trade Names:
Epifoam
- Foam 1% hydrocortisone/1% pramoxine

Trade Names:
HC Pramoxine
- Cream 2.5% hydrocortisone/1% pramoxine

Trade Names:
Pramosone
- Cream 1% hydrocortisone/1% pramoxine
- Cream 2.5% hydrocortisone/1% pramoxine
- Lotion 1% hydrocortisone/1% pramoxine
- Lotion 2.5% hydrocortisone/1% pramoxine
- Ointment 1% hydrocortisone/1% pramoxine
- Ointment 2.5% hydrocortisone/1% pramoxine

Trade Names:
ProctoFoam-HC
- Foam 1% hydrocortisone/1% pramoxine

Mechanism of Action

Pharmacology

Hydrocortisone

Depresses formation, release and activity of endogenous mediators of inflammation, as well as modifying body's immune response.

Pramoxine

Stabilizes the neuronal membrane of nerve endings with which it comes in contact.

Indications and Usage

Topical relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Contraindications

History of hypersensitivity to any component of the product.

Dosage and Administration

Topical

Apply to the affected area as a thin film 3 or 4 times daily, depending on severity of the condition. Administration of topical corticosteroids to children should be limited to the least amount compatible with an effective therapeutic regimen.

General Advice

  • For topical use only. Not for ophthalmic or otic use.
  • Do not apply an occlusive dressing unless ordered by health care provider.

Storage/Stability

Store at controlled room temperature (59° to 86°F). Keep tube tightly closed.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

Dermatologic

Burning; itching; irritation; dryness; folliculitis; hypertrichosis; acneiform eruptions; hyperpigmentation; perioral dermatitis; allergic contact dermatitis; maceration of the skin; secondary infection; skin atrophy; striae; miliaria.

Precautions

Pregnancy

Category C .

Lactation

Undetermined; however, systemic hydrocortisone is excreted in breast milk.

Children

Children may demonstrate greater susceptibility to topical corticosteroids-induced hypothalamic-pituitary-adrenal (HPA) axis suppression and Cushing syndrome than mature patients because of a larger skin surface area to body weight ratio.

Topical absorption

Systemic absorption of topical corticosteroids can produce reversible HPA axis suppression, manifestations of Cushing syndrome, hyperglycemia, and glucosuria.

Overdosage

Symptoms

HPA axis suppression; manifestations of Cushing syndrome, hyperglycemia, and glucosuria, especially when large surface areas, prolonged use, or occlusive dressings are involved.

Patient Information

  • Review prescribed dosing schedule with patient or caregiver.
  • Remind patient or caregiver that cream is not to be used in the eye or ear.
  • Teach patient or caregiver proper technique for applying product: wash hands; apply thin film to affected area(s) using fingers or applicator. Wash hands after applying product.
  • Caution patient or caregiver to not cover area with an occlusive dressing unless advised by health care provider.
  • Advise patient or caregiver to contact health care provider if local redness or swelling develops or if skin lesions do not improve or worsen.

Recent Drug Updates at DrugIndexOnline:





Dantrolene Capsules Dantrolene Capsules
Generic Name: Dantrolene Capsules (DAN-troe-leen) Brand Name: DantriumDantrolene Capsules may cause serious, even fatal, liver problems, especially when used in larger amounts (800 mg/day or more). This side effect has occurred even in people who have taken Dantrolene Capsules for a short period more...

Desenex Antifungal Liquid Topical Desenex Antifungal Liquid Topical
Some commonly used brand names are: In the U.S.— Caldesene Medicated Powder Cruex Antifungal Cream Cruex Antifungal Powder Cruex Antifungal Spray Powder Decylenes Powder Desenex Antifungal Cream Desenex Antifungal Liquid Desenex Antifungal Ointment Desenex Antifungal Penetrating Foam Dese more...

Dipyridamole Tablets Dipyridamole Tablets
Generic Name: Dipyridamole Tablets (dye-peer-ID-a-mole) Brand Name: PersantineDipyridamole is used for:Preventing blood clots after heart valve surgery. It is used in combination with anticoagulants (eg, warfarin). It also may be used for other conditions as determined by your doctor. Dipyridamo more...

Hydrocodone Bitartrate/Homatropine Methylbromide Hydrocodone Bitartrate/Homatropine Methylbromide
Pronouncation: (HIGH-droe-KOE-dohn by-TAR-trate/hoe-MAT-troe-peen METH-ill-BROE-mide) Class: Antitussive combination Trade Names: Hycodan - Syrup 5 mg hydrocodone bitartrate and 1.5 mg homatropine methylbromide Trade Names: Tussigon - Tablets 5 mg hydrocodone bitartrate and 1.5 mg homatropine methy more...

Isomil Isomil
Some commonly used brand names are: In the U.S.— Alimentum 1 Alsoy 3 Carnation Follow-Up Formula 2 Carnation Good Start 2 Enfamil 2 Enfamil Human Milk Fortifier 2 Enfamil with Iron 2 Enfamil Premature Formula 2 Enfamil Premature Formula with Iron 2 Gerber Baby Formula with Iron 2 Gerber S more...

Lemohist Plus Lemohist Plus
Generic Name: Chlorpheniramine/Guaifenesin/Pseudoephedrine Capsules (klor-fen-EER-a-meen/gwye-FEN-e-sin/sue-do-eh-FED-rin) Brand Name: Lemohist PlusLemohist Plus is used for:Relieving symptoms of sinus congestion, runny nose, sneezing, and throat and airway irritation due to colds, upper respir more...

Linezolid Linezolid
Generic Name: Linezolid Injection (li-NE-zoh-lid) Brand Name: ZyvoxLinezolid is used for:Treating adults with certain serious bacterial infections that are often resistant to other antibiotics. Linezolid is an oxazolidinone antibiotic. It works by interfering with the production of proteins ne more...

Ocu-Sul-15 Ophthalmic Ocu-Sul-15 Ophthalmic
Some commonly used brand names are: In the U.S.— Ak-Sulf 1 Bleph-10 1 Cetamide 1 Gantrisin 2 Isopto-Cetamide 1 I-Sulfacet 1 Ocu-Sul-10 1 Ocu-Sul-15 1 Ocu-Sul-30 1 Ocusulf-10 1 Ophthacet 1 Sodium Sulamyd 1 Spectro-Sulf 1 Steri-Units Sulfacetamide 1 Sulf-10 1 Sulfair 1 Sulfair 10 1 Sulfair more...