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All about: Hydromorphone Suppository

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Generic Name: Hydromorphone Suppository (HYE-droe-MOR-fone)
Brand Name: Dilaudid

Hydromorphone Suppository is used for:

Treating pain in certain patients.

Hydromorphone Suppository is an opioid (narcotic) analgesic. It works by binding to certain receptors in the brain and nervous system to reduce pain.

Do NOT use Hydromorphone Suppository if:

  • you are allergic to any ingredient in Hydromorphone Suppository or any other codeine or morphine related medicine (eg, morphine, codeine, oxycodone)
  • you have difficult or slowed breathing, chronic obstructive pulmonary disease (COPD), or right-sided heart problems (cor pulmonale), or you are having a severe asthma attack
  • you are in labor
  • you have severe diarrhea or other bowel problems caused by antibiotics or poisoning
  • you have a brain injury or growths in the brain along with increased pressure in the brain
  • you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hydromorphone Suppository:

Some medical conditions may interact with Hydromorphone Suppository. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of lung or breathing problems (eg, asthma, emphysema, bronchitis), seizures (eg, epilepsy), adrenal gland problems, an enlarged prostate, heart problems, low blood pressure, dehydration, low blood volume, an underactive thyroid, or urinary blockage
  • if you have severe drowsiness, a recent head injury, spinal problems, growths in the brain, or increased pressure in the brain
  • if you have liver or kidney problems, gallbladder problems, or stomach or bowel problems (eg, inflammation), or if you have had recent stomach or bowel surgery
  • if you drink alcohol regularly, have symptoms of alcohol withdrawal, or have a history of suicidal thoughts or attempts
  • if you have a personal or family history of mental or mood problems, alcohol abuse, or other substance abuse or dependence
  • if you are in poor health or shock, or will be having surgery

Some MEDICINES MAY INTERACT with Hydromorphone Suppository. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Phenothiazines (eg, chlorpromazine) because the risk of low blood pressure may be increased
  • Barbiturate anesthetics (eg, thiopental), cimetidine, or sodium oxybate (GHB) because the risk of severe drowsiness, coma, or slowed or difficult breathing may be increased
  • Agonist/antagonist analgesics (eg, pentazocine) or naltrexone because they may decrease Hydromorphone Suppository's effectiveness and withdrawal may occur

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hydromorphone Suppository may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hydromorphone Suppository:

Use Hydromorphone Suppository as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Wash your hands before and after using Hydromorphone Suppository.
  • If the suppository is too soft to use, put it in the refrigerator for about 15 minutes. You may also run cold water over it.
  • Remove the wrapper. Moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum. Use your finger to push it in completely.
  • If you are taking Hydromorphone Suppository for persistent pain, take it on a regular schedule to help control the pain more effectively.
  • Do not change your dose or suddenly stop taking Hydromorphone Suppository without checking with your doctor.
  • If you miss a dose of Hydromorphone Suppository and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hydromorphone Suppository.

Important safety information:

  • Hydromorphone Suppository may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol, other opiate pain medicines, or certain other medicines. Use Hydromorphone Suppository with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you take Hydromorphone Suppository; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Hydromorphone Suppository may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Hydromorphone Suppository may be habit forming. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Misuse or abuse of Hydromorphone Suppository may cause severe side effects, including severe breathing problems, seizures, coma, and possibly death.
  • Constipation is a common side effect of Hydromorphone Suppository. Talk to your doctor about using laxatives or stool softeners to prevent or treat constipation while you use Hydromorphone Suppository.
  • If your pain continues or becomes worse or if you have side effects that concern you, contact your doctor.
  • Tell your doctor or dentist that you take Hydromorphone Suppository before you receive any medical or dental care, emergency care, or surgery.
  • Use Hydromorphone Suppository with caution in the ELDERLY; they may be more sensitive to its effects, especially drowsiness and breathing problems.
  • Hydromorphone Suppository should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Hydromorphone Suppository may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hydromorphone Suppository while you are pregnant. Hydromorphone Suppository is found in breast milk. Do not breast-feed while taking Hydromorphone Suppository.

When used for long periods of time or at high doses, Hydromorphone Suppository may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Hydromorphone Suppository stops working well. Do not take more than prescribed.

Some people who use Hydromorphone Suppository for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. Dependence is unlikely to be an issue in terminally ill patients where comfort is more important. If you are taking Hydromorphone Suppository regularly, do not suddenly stop taking it without checking with your doctor. WITHDRAWAL symptoms have occurred when Hydromorphone Suppository is suddenly stopped and may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea and vomiting; pain; rigid muscles; seeing, hearing, or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping. Contact your doctor if you notice any of these symptoms after stopping Hydromorphone Suppository.

Possible side effects of Hydromorphone Suppository:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness, drowsiness; dry mouth; flushing; lightheadedness; nausea; sweating; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; fast, slow, or irregular heartbeat; hallucinations; mental or mood changes; seizure or persistent dizziness or drowsiness; severe or persistent headache or vomiting; shallow, slowed or difficult breathing; tremor; trouble urinating; vision changes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include bluish skin; chest pain; cold/clammy skin; coma; difficult or slow breathing; excessive sweating; limp muscles; nausea and vomiting; numbness of an arm or leg; pinpoint pupils; seizures; severe drowsiness or dizziness; slow or irregular heartbeat.

Proper storage of Hydromorphone Suppository:

Store Hydromorphone Suppository in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Keep Hydromorphone Suppository out of the reach of children and away from pets. Once Hydromorphone Suppository is no longer needed, dispose of it by flushing it down the toilet.

General information:

  • If you have any questions about Hydromorphone Suppository, please talk with your doctor, pharmacist, or other health care provider.
  • Hydromorphone Suppository is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hydromorphone Suppository. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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