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All about: Hylenex injectable

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Generic Name: hyaluronidase (injectable) (hi al yor ON ih days)
Brand Names: Hylenex, Vitrase, Wydase

What is hyaluronidase?

Hyaluronidase is a genitically designed protein.

Hyaluronidase is used as an aid in helping your body absorb other injected medications.

Hyaluronidase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.

What is the most important information I should know about hyaluronidase?

Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication.

Before receiving hyaluronidase, tell your doctor if you are using any of the following drugs: furosemide (Lasix); phenytoin (Dilantin); a sedative or anxiety medication (such as Valium, Xanax, Tranxene); aspirin or salicylates; cortisone or ACTH (Corticotropin); estrogens; or an antihistamine (such as a cold or allergy medicine).

What should I discuss with my health care provider before receiving hyaluronidase?

Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication.

Hyaluronidase is in the FDA pregnancy category C. This means that it is not known if it will be harmful to an unborn baby. Do not receive this medication without telling your doctor if you are pregnant. Tell your doctor if you become pregnant during treatment. It is not known if hyaluronidase passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How should I use hyaluronidase?

This medication is given as an injection under the skin. You will receive the injection from a doctor or other healthcare professional.

What happens if I miss a dose?

If you are to receive this medication more than one time, call your doctor for instructions if you miss a dose.

What happens if I overdose?

Symptoms of a hyaluronidase overdose may include itching or swelling where the injection was given. Other possible symptoms include chills, dizziness, nausea, vomiting, fast heartbeat, or fainting.

What should I avoid while receiving hyaluronidase?

Ask your doctor about any food, drink, or other medications you should avoid while you are receiving hyaluronidase.

Hyaluronidase side effects

Tell your doctor right away if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Other, less serious side effects may be more likely to occur. Tell your doctor if you have any of these side effects:

  • pain or tenderness where the medication was injected; or

  • swelling in any part of your body.

What other drugs will affect hyaluronidase?

Before receiving hyaluronidase, tell your doctor if you are using any of the following drugs:

  • furosemide (Lasix);

  • phenytoin (Dilantin);

  • a sedative or anxiety medication (such as Valium, Xanax, Tranxene);

  • aspirin or salicylates;

  • cortisone or ACTH (Corticotropin);

  • estrogens; or

  • an antihistamine (such as a cold or allergy medicine).

If you are using any of these drugs, you may not be able to receive hyaluronidase, or you may require a dosage adjustment or special monitoring.

There may be other drugs not listed that can affect hyaluronidase. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors.

Where can I get more information?

  • Your pharmacist has more information about hyaluronidase written for health professionals that you may read.

  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.04. Revision Date: 3/6/06 10:40:37 AM.

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