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All about: Hyoscyamine Extended-Release Capsules

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Generic Name: Hyoscyamine Extended-Release Capsules (HYE-oh-SYE-a-meen)
Brand Name: Levsinex

Hyoscyamine Extended-Release Capsules is used for:

Treating certain stomach, intestinal, and bladder conditions, including spasms. It is used to control stomach secretions and cramps. It is used to relieve the symptoms of colic, runny nose, and Parkinson-like problems. It is used to treat excessive sweating or saliva production. It may also be used for other conditions as determined by your doctor.

Hyoscyamine Extended-Release Capsules is an anticholinergic agent. It works by decreasing the motion of muscles in the stomach, intestines, and bladder. It also decreases the production of stomach acid.

Do NOT use Hyoscyamine Extended-Release Capsules if:

  • you are allergic to any ingredient in Hyoscyamine Extended-Release Capsules
  • you have severe esophagus problems (eg, irritation, narrowing); a blockage of the stomach, bowel, or bladder; bowel motility problems; or severe bowel problems (eg, severe ulcerative colitis, toxic megacolon)
  • you have glaucoma, myasthenia gravis, or heart problems caused by severe bleeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Hyoscyamine Extended-Release Capsules:

Some medical conditions may interact with Hyoscyamine Extended-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have nerve problems, prostate problems, stomach or bowel problems, heart or blood vessel problems (eg, fast or irregular heartbeat, heart failure, coronary heart disease), hiatal hernia, kidney problems, an overactive thyroid, high blood pressure, urinary problems, paralysis, or brain damage, or if you are at risk for glaucoma
  • if you have diarrhea or fever, have been very ill, or are in poor health

Some MEDICINES MAY INTERACT with Hyoscyamine Extended-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Amantadine, antihistamines (eg, diphenhydramine), haloperidol, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine), other anticholinergics (eg, scopolamine), phenothiazines (eg, thioridazine), or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Hyoscyamine Extended-Release Capsules's side effects
  • Narcotic pain medicines (eg, codeine) or potassium chloride because the risk of their side effects may be increased by Hyoscyamine Extended-Release Capsules
  • Metoclopramide because its effectiveness may be decreased by Hyoscyamine Extended-Release Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Hyoscyamine Extended-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Hyoscyamine Extended-Release Capsules:

Use Hyoscyamine Extended-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Hyoscyamine Extended-Release Capsules is usually taken 30 to 60 minutes before a meal. Follow your doctor's specific instructions for taking Hyoscyamine Extended-Release Capsules.
  • Swallow Hyoscyamine Extended-Release Capsules whole. Do not break, crush, or chew before swallowing.
  • If you also take antacids, ask your doctor or pharmacist how to take them with Hyoscyamine Extended-Release Capsules.
  • If you miss a dose of Hyoscyamine Extended-Release Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Hyoscyamine Extended-Release Capsules.

Important safety information:

  • Hyoscyamine Extended-Release Capsules may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Hyoscyamine Extended-Release Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Hyoscyamine Extended-Release Capsules will add to the effects of alcohol and other medicines that may cause drowsiness (eg, sleep aids, muscle relaxers). Ask your pharmacist if you have any questions about which medicines may cause drowsiness.
  • Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Drink plenty of fluids, maintain good oral hygiene, and suck on sugarless hard candy to relieve dry mouth.
  • Proper dental care is important while you are taking Hyoscyamine Extended-Release Capsules. Brush and floss your teeth and visit the dentist regularly.
  • Hyoscyamine Extended-Release Capsules may make your eyes more sensitive to sunlight. It may help to wear sunglasses.
  • You may notice undissolved parts of Hyoscyamine Extended-Release Capsules in your stool. This is normal and not a cause for concern.
  • Use Hyoscyamine Extended-Release Capsules with caution in the ELDERLY; they may be more sensitive to its effects, especially constipation, trouble urinating, drowsiness, agitation, confusion, or excitement.
  • Caution is advised when using Hyoscyamine Extended-Release Capsules in CHILDREN; they may be more sensitive to its effects.
  • Hyoscyamine Extended-Release Capsules should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if Hyoscyamine Extended-Release Capsules can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Hyoscyamine Extended-Release Capsules while you are pregnant. Hyoscyamine Extended-Release Capsules is found in breast milk. If you are or will be breast-feeding while taking Hyoscyamine Extended-Release Capsules, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Hyoscyamine Extended-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bloated feeling; blurred vision; constipation; decreased sweating; dizziness; drowsiness; dry mouth; enlarged pupils; excitement; headache; nausea; nervousness; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; behavior changes; confusion; decreased sexual ability; diarrhea; difficulty focusing eyes; disorientation; exaggerated sense of well-being; fast or irregular heartbeat; hallucinations; loss of consciousness; loss of coordination; memory loss; mental or mood changes; severe or persistent trouble sleeping; speech changes; taste changes; trouble urinating; unusual tiredness or weakness; vision changes; vomiting.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include disorientation; excessive thirst or excitability; fever; hot, dry skin; seizures; severe dry mouth; severe or persistent blurred vision, headache, dizziness, nausea, or vomiting; trouble breathing or swallowing.

Proper storage of Hyoscyamine Extended-Release Capsules:

Store Hyoscyamine Extended-Release Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Hyoscyamine Extended-Release Capsules out of the reach of children and away from pets.

General information:

  • If you have any questions about Hyoscyamine Extended-Release Capsules, please talk with your doctor, pharmacist, or other health care provider.
  • Hyoscyamine Extended-Release Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Hyoscyamine Extended-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition
Copyright © 2007 Wolters Kluwer Health, Inc.

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