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All about: Ifex Solution

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Generic Name: Ifosfamide Injection Solution (eye-FOSS-fuh-mide)
Brand Name: Ifex

Ifex Solution should only be used under the supervision of a doctor experienced with the use of cancer medicines. Bladder effects (eg, bleeding, inflammation) or central nervous system effects (eg, confusion, coma) may occur with use of Ifex Solution. Contact your doctor immediately if you experience any of these symptoms. Ifex Solution may also cause bone marrow depression.


Ifex Solution is used for:

Treating certain types of cancer in combination with other medicines. It is also usually used along with a medicine called mesna, which decreases the risk of bleeding in the bladder.

Ifex Solution is an antineoplastic. It works by stopping the growth of certain cancers.

Do NOT use Ifex Solution if:

  • you are allergic to any ingredient in this medicine
  • you have severe bone marrow depression
  • you are in your first 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ifex Solution:

Some medical conditions may interact with Ifex Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver or kidney disease, bone marrow depression, an infection, chickenpox, or shingles
  • if you have had radiation therapy

Some MEDICINES MAY INTERACT with Ifex Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Digoxin because its effectiveness may be decreased by Ifex Solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ifex Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ifex Solution:

Use Ifex Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Ifex Solution is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Ifex Solution at home, carefully follow the injection procedures taught to you by your health care provider.
  • If the medicine contains particles or is discolored, or if the vial/container is cracked or damaged in any way, do not use it.
  • Drinking extra fluids while you are taking Ifex Solution is recommended. Check with your doctor or nurse for instructions.
  • Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for selecting an appropriate container and properly disposing of the container when full.
  • If you miss a dose of Ifex Solution, contact your doctor immediately for dosing instructions.

Ask your health care provider any questions you may have about how to use Ifex Solution.

Important safety information:

  • Ifex Solution may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Ifex Solution. Using Ifex Solution alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Empty your bladder regularly. Your doctor may recommend that you get up at least once during the night to urinate.
  • Ifex Solution may reduce the number of blood cells that are needed for clotting. To prevent bleeding, avoid situations where bruising or injury may occur.
  • Ifex Solution may decrease your body's ability to heal itself. To prevent wounds, avoid situations where bruising or injury may occur.
  • Ifex Solution may lower your body's ability to fight infection. To prevent infection, avoid contact with people who have colds or other infections. Do not touch your eyes or the inside of your nose unless you have thoroughly washed your hands first.
  • If nausea, vomiting, or loss of appetite occurs, ask your doctor, nurse, or pharmacist for ways to lessen these effects.
  • Check with your doctor before having vaccinations while you are using Ifex Solution.
  • Use Ifex Solution with extreme caution in CHILDREN; safety and effectiveness have not been confirmed.
  • LAB TESTS, including kidney function, complete blood cell count, and urine tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: Ifex Solution has been shown to cause harm to the fetus. If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Ifex Solution during pregnancy. Ifex Solution is excreted in breast milk. Do not breast-feed while taking Ifex Solution.

Possible side effects of Ifex Solution:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Hair loss; loss of appetite; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abdominal pain; blood in the urine; confusion; cough; dizziness; fever or chills; hallucinations; irregular or absent menstrual periods; joint pain; mood changes; painful or frequent urination; shortness of breath; sleepiness; sore throat; sores on the mouth or lips; unusual bruising or bleeding; unusual fatigue; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Ifex Solution:

Powder for injection should be stored at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. After solution has been properly mixed, it may be stored at room temperature for 7 days or refrigerated between 36 and 46 degrees F (2 and 8 degrees C) for up to 21 days. Do not store Ifex Solution in the bathroom. Keep Ifex Solution, as well as needles and syringes, out of the reach of children and away from pets.

General information:

  • If you have any questions about Ifex Solution, please talk with your doctor, pharmacist, or other health care provider.
  • Ifex Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Ifex Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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