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All about: Imipramine Capsules

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Generic Name: Imipramine Capsules (im-IP-ra-meen)
Brand Name: Tofranil-PM

Antidepressants may increase the risk of suicidal thoughts or actions in children and teenagers. The risk may be greater during the first few months that patients take Imipramine Capsules. Be sure that the benefits of using Imipramine Capsules outweigh the risks. Talk with the patient's doctor if you have any questions.

Family and caregivers must closely observe patients who take Imipramine Capsules. It is important to keep in close contact with the patient's doctor. Tell the doctor right away if the patient has symptoms like worsened depression, suicidal thoughts, or changes in behavior.


Imipramine Capsules is used for:

Treating depression. It may also be used for other conditions as determined by your doctor.

Imipramine Capsules is a tricyclic antidepressant. It works by increasing the activity of certain chemicals in the brain that help elevate mood.

Do NOT use Imipramine Capsules if:

  • you are allergic to any ingredient in Imipramine Capsules or to similar medicines
  • you have taken furazolidone or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days, or you are taking astemizole, droperidol, or terfenadine
  • you are recovering from a recent heart attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using Imipramine Capsules:

Some medical conditions may interact with Imipramine Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you drink alcohol-containing beverages daily or you have a history of alcohol abuse
  • if you take thyroid medicine or you have a history of overactive thyroid, glaucoma, heart problems, kidney or liver problems, diabetes, seizures, the blood disease porphyria, or difficulty urinating
  • if you have a history of suicidal thoughts or behavior, bipolar disorder, or any other mental disorders; you are undergoing electroshock therapy; or you are scheduled to have any surgery

Some MEDICINES MAY INTERACT with Imipramine Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Azole antifungals (eg, fluconazole), cimetidine, duloxetine, flecainide, methylphenidate, mibefradil, phenothiazines (eg, chlorpromazine), propafenone, quinidine, selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine), or terbinafine because they may increase the risk of Imipramine Capsules's side effects
  • Arsenic, astemizole, droperidol, furazolidone, MAOIs (eg, phenelzine), pimozide, streptogramins (eg, dalfopristin), terfenadine, or tramadol because the risk of high blood pressure, serious heart problems (eg, irregular heartbeat), or seizures may be increased
  • Barbiturates (eg, phenobarbital) or phenytoin because they may decrease Imipramine Capsules's effectiveness
  • Anticholinergics (eg, benztropine), carbamazepine, or sympathomimetics (eg, phenylephrine) because the risk of their side effects may be increased by Imipramine Capsules
  • Clonidine, guanethidine, or guanfacine because their effectiveness may be decreased by Imipramine Capsules

This may not be a complete list of all interactions that may occur. Ask your health care provider if Imipramine Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Imipramine Capsules:

Use Imipramine Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Imipramine Capsules comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Imipramine Capsules refilled.
  • Take Imipramine Capsules by mouth with or without food.
  • Taking Imipramine Capsules at bedtime may help reduce side effects (eg, daytime drowsiness). Discuss this possibility with your doctor.
  • It may take 1 to 3 weeks before you notice the effect of Imipramine Capsules. Continue to use Imipramine Capsules even if you feel well. Do not miss any doses.
  • If you miss a dose of Imipramine Capsules, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. If you take 1 dose daily at bedtime, do not take the missed dose the next morning.

Ask your health care provider any questions you may have about how to use Imipramine Capsules.

Important safety information:

  • Imipramine Capsules may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Imipramine Capsules with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Imipramine Capsules; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Imipramine Capsules may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Children and teenagers who take Imipramine Capsules may be at increased risk for suicidal thoughts or actions. Adults may also be affected. The risk may be greater in patients who have had suicidal thoughts or actions in the past. The risk may also be greater in patients who have had bipolar (manic-depressive) illness, or if their family members have had it. Watch patients who take Imipramine Capsules closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
  • Imipramine Capsules may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Imipramine Capsules. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Imipramine Capsules before you receive any medical or dental care, emergency care, or surgery.
  • Lab tests, including blood counts, may be performed while you use Imipramine Capsules. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Imipramine Capsules with caution in the ELDERLY (especially those with cardiac disease); they may be more sensitive to its effects.
  • Imipramine Capsules should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if Imipramine Capsules can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Imipramine Capsules while you are pregnant. It is not known if Imipramine Capsules is found in breast milk. Do not breast-feed while taking Imipramine Capsules.

If you suddenly stop taking Imipramine Capsules, you may experience WITHDRAWAL symptoms, including headache, nausea, and tiredness.

Possible side effects of Imipramine Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth; excitement; headache; impotence; nausea; nightmares; pupil dilation; sensitivity to sunlight; sweating; tiredness; upset stomach; vomiting; weakness; weight loss or gain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; changes in sex drive; chest pain; confusion; constipation; fainting; fast, slow, or irregular heartbeat; fever; frequent or difficult urination; hallucinations; impulsive behavior or other unusual changes in behavior; jaw, neck, or muscle spasms; mental or mood changes (eg, increased anxiety, mood swings, agitation, irritability, nervousness, restlessness); panic attacks; ringing in the ears; seizures; severe dizziness or drowsiness; sore throat; stomach pain; suicidal thinking or behavior; swelling of the testicles; tremor; trouble sleeping; trouble walking or keeping your balance; twitching of the face or tongue; uncontrolled movements of arms and legs or stiffness; unusual bleeding or bruising; worsening of depression; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include agitation; bluish skin or mucous membranes; breathing problems; chest pain; coma; confusion; dry mouth; enlarged pupils; excess sweating; fainting; fast or irregular heartbeat; flushing; incoordination; involuntary movements; loss of consciousness; restlessness; rigid muscles; seizures; severe drowsiness; shock; stupor; vomiting.

Proper storage of Imipramine Capsules:

Store Imipramine Capsules at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in a tightly sealed container. Stored away from heat, moisture, and light. Do not store in the bathroom. Keep Imipramine Capsules out of the reach of children and away from pets.

General information:

  • If you have any questions about Imipramine Capsules, please talk with your doctor, pharmacist, or other health care provider.
  • Imipramine Capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Imipramine Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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