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All about: Indapamide

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Generic name: Indapamide
Brand names: Lozol

Why is Indapamide prescribed?

Lozol is used in the treatment of high blood pressure, either alone or in combination with other high blood pressure medications. Lozol is also used to relieve salt and fluid retention. During pregnancy, your doctor may prescribe Lozol to relieve fluid retention caused by a specific condition or when fluid retention causes extreme discomfort that is not relieved by rest.

Most important fact about Indapamide

If you have high blood pressure, you must take Lozol regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Lozol; and you must continue taking it even if you are feeling well. Lozol does not cure high blood pressure; it merely keeps it under control.

How should you take Indapamide?

Take Lozol exactly as prescribed by your doctor. Suddenly stopping Lozol could cause your condition to worsen.

Lozol is best taken in the morning.

--If you miss a dose...

Take the forgotten dose as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Never take two doses at the same time.

--Storage instructions...

Store Lozol at room temperature. Protect from excessive heat. Keep the container tightly closed.

What side effects may occur?

Side effects cannot be anticipated. If any side effects develop or change in intensity, tell your doctor immediately. Only your doctor can determine whether it is safe to continue taking Lozol. Most side effects are mild and temporary.

  • More common side effects may include:
    Agitation, anxiety, back pain, dizziness, headache, infection, irritability, muscle cramps or spasms, nasal inflammation, nervousness, numbness in hands and feet, pain, tension, weakness, fatigue, loss of energy or tiredness

Why should Indapamide not be prescribed?

Avoid using Lozol if you are unable to urinate or if you have ever had an allergic reaction or are sensitive to indapamide or other sulfa-containing drugs.

Special warnings about Indapamide

Diuretics such as Lozol can cause the body to lose too much salt and potassium, especially among elderly women. Signs of an excessively low potassium level include muscle weakness and rapid or irregular heartbeat. To boost your potassium level, your doctor may recommend eating potassium-rich foods or taking a potassium supplement.

The risk of potassium loss increases when larger doses are used, if you have cirrhosis, or if you are also using corticosteroids or ACTH. Your doctor should check your blood regularly, especially if you have an irregular heartbeat or are taking heart medications.

Lozol should be used with care if you have gout or high uric acid levels, liver disease, diabetes, or lupus erythematosus, a disease of the connective tissue.

This medication should be used with caution if you have severe kidney disease. Your kidney function should be given a complete assessment and should continue to be monitored.

In general, diuretics should not be taken if you are taking lithium, as they increase the risk of lithium poisoning.

Safety and effectiveness in children have not been established.

Possible food and drug interactions when taking Indapamide

If Lozol is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Lozol with the following:

Lithium (Eskalith)
Norepinephrine (a drug used to treat cardiac arrest and to maintain blood pressure)
Other high blood pressure medications such as Aldomet and Tenormin

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, tell your doctor immediately. No information is available about the safety of Lozol during pregnancy.

Lozol may appear in breast milk and could affect a nursing infant. If Lozol is essential to your health, your doctor may advise you to stop breastfeeding until your treatment is finished.

Recommended dosage


High Blood Pressure

The usual starting dose is 1.25 milligrams as a single daily dose taken in the morning. If Lozol does not seem to be working for you, your doctor may gradually increase your dosage up to 5 milligrams taken once a day.

Fluid Buildup in Congestive Heart Failure

The usual starting dose is 2.5 milligrams as a single daily dose taken in the morning. Your doctor may increase your dosage to 5 milligrams taken once daily.


Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical treatment immediately.

  • Symptoms of Lozol overdose may include:
    Electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness

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