25 . September , 2018 - Tuesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Infliximab

Big Image

Some commonly used brand names are:

In the U.S.—

  • Remicade

In Canada—

  • Remicade

Another commonly used name is cA2 .


  • Inflammatory bowel disease therapy agent
  • antirheumatic agent


Infliximab (in-FLIX-i-mab) is a monoclonal antibody. It is used to treat Crohn's disease in patients who have not been helped by other medicines and also in patients who have a type of Crohn's disease in which fistulas form. It is also used to treat rheumatoid arthritis and ankylosing spondylitis which is a type of arthritis that affects the joints in the spine. In addition, it is used to treat psoriatic arthritis which is a type of arthritis that causes pain and swelling of the joints and patches of scaly skin on some areas of the body. Psoriatic arthritis is related to the skin condition, psoriasis. Infliximab is also used to treat ulcerative colitis.

This medicine is available only with your doctor's prescription, in the following dosage form:

  • Injection (U.S. and Canada)

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For infliximab, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to infliximab or to rodents (such as rats or mice). Mouse cells are used in the preparation of infliximab. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Studies have not been done in either humans or animals. It is not known if infliximab causes harmful effects on the fetus. Before receiving this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—It is not known whether infliximab passes into breast milk. Because of the risk of harmful effects in the nursing baby, it may be necessary for you to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of infliximab in children with use in other age groups.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of infliximab in the elderly with use in other age groups. However, older adults generally get more infections than do younger adults, and it is not known if infliximab may affect the number of infections that older people get.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking infliximab, it is especially important that your health care professional knows if you are taking any of the following:

  • Anakinra (e.g., Kineret)—Serious infection may occur if infliximab is used together with this medicine.
  • Immunosuppressive therapy (medicine that helps prevent your body from rejecting an organ transplant)—May cause you to have a greater risk of getting a serious infection or a lymphoma (a type of blood cancer)

Other medical problems—The presence of other medical problems may affect the use of infliximab. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood problems, ongoing or in the past—Caution should be used.
  • Cancer, history—This medicine should be used with caution. If you have a history of cancer, you may be more susceptible to lymphoma (a type of blood cancer).
  • Heart disease—Infliximab is not recommended for patients with a certain type of heart disease called congestive heart failure.
  • Hepatitis B—Infliximab could cause your hepatitis B to become active again if you have a history of hepatitis B.
  • Infection—Infliximab is not recommended for patients with an active infection. Caution should be used if you have a chronic infection or history of a recurring infection.
  • Inactive tuberculosis infection—Should be treated before starting infliximab therapy.
  • Nervous system problems or
  • Seizures—Caution should be used; your doctor will consider discontinuing this medicine if you develop serious CNS reactions.

Proper Use of This Medicine

Dosing—You will be given a Patient Information Sheet prior to each treatment. Make sure you read it each time you are scheduled for an infliximab treatment.

The dose of infliximab will be different for different patients. Infliximab is usually given by a doctor or nurse. The following information includes only the average dose of infliximab.

  • For treatment of Crohn's disease. ankylosing spondylitis, psoriatic arthritis, or ulcerative colitis:
    • Adults—5 milligrams (mg) per kilogram (kg) (2.27 mg per pound) of body weight, injected into a vein.
    • Children—Use and dose must be determined by your doctor.
  • For treatment of rheumatoid arthritis:
    • Adults—3 milligrams (mg) per kilogram (kg) (1.36 mg per pound) of body weight, injected into a vein
    • Children—Use and dose must be determined by your doctor.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Store away from heat and direct light.
  • Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
  • Store in the refrigerator. However, keep the medicine from freezing.
  • Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

Infliximab may cause chest pain, fever, chills, itching, hives, flushing of face, or troubled breathing within a few hours after you receive it. Check with your doctor or nurse immediately if you have any of these symptoms.

Check with your doctor immediately if you have any symptoms of liver problems including skin and eyes turning yellow, dark brown-colored urine, right sided abdominal pain, fever or severe tiredness.

It is important to have a tuberculin skin test to make sure that you do not have an inactive tuberculosis infection, which could worsen while you are on infliximab therapy.

It is important to have your heart closely checked if you take infliximab, and have existing heart disease, which could worsen while you are on infliximab therapy

Your doctor will check you for active infections before each infliximab treatment. Tell your doctor if you are not feeling well or if you have symptoms of a cold or other type of infection.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Chest pain; chills; fever; flushing of face; hives; itching; troubled breathing

Check with your doctor as soon as possible if any of the following side effects occur:

More common

Abdominal pain; cough; dizziness; fainting; headache; muscle pain; nasal congestion; nausea; runny nose; shortness of breath; sneezing; sore throat; tightness in chest; unusual tiredness or weakness; vomiting; wheezing

Less common

Back pain; bloody or cloudy urine; cracks in skin at the corners of mouth; diarrhea; difficult or painful urination; frequent urge to urinate; high blood pressure; low blood pressure; pain; pain or tenderness around eyes and cheekbones; skin rash; soreness or irritation of mouth or tongue; soreness or redness around fingernails or toenails; vaginal burning or itching and discharge; white patches in mouth and/or on tongue


Abscess (swollen, red, tender area of infection containing pus); back or side pain; black, tarry stools; blood in urine or stools; bone or joint pain; constipation; falls; feeling of fullness; general feeling of illness; hernia (bulge of tissue through the wall of the abdomen); infection; irregular or pounding heartbeat ; pain in rectum; pain spreading from the abdomen to the left shoulder; pinpoint red spots on skin; stomach pain (severe); swollen or painful glands; tendon injury; unusual bleeding or bruising; weight loss (unusual); yellow skin and eyes

Incidence not known—occurred during clinical practice

Area rash; bloody nose; burning, tingling, numbness or pain in the hands, arms, feet or legs; change in mental status; clay-colored stools; continuing vomiting; convulsions; dark or bloody urine; difficulty breathing; difficulty speaking; difficulty swallowing; fast heartbeat; general feeling of tiredness or weakness; heavier menstrual periods; hives; hoarseness; inability to move arms and legs; itching, puffiness, or swelling of the eyelids or around the eyes, face, lips or tongue Light-colored stools; loss of appetite; loss of bladder control; lower back or side pain; muscle spasm or jerking of all extremities; noisy breathing; painful or difficult urination; pale skin; redness, soreness or itching skin; seizures; sensation of pins and needles; severe abdominal pain; severe muscle weakness, sudden and progressing; slow or irregular breathing; sore throat; sores, welting, or blisters; stabbing pain; stomach pain; sudden loss of consciousness; sudden numbness and weakness in the arms and legs; ulcers, sore, or white spots in mouth; unpleasant breath odor; upper right abdominal pain; vomiting of blood

Additional Information

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in the product labeling, infliximab is used in certain patients with the following medical conditions:

  • Psoriasis
  • Reactive arthritis
  • Inflammatory bowel disease arthritis

Other than the above information, there is no additional information relating to proper use, precautions, or side effects for this use.

Developed: 05/05/1999
Revised: 10/04/2005

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

Recent Drug Updates at DrugIndexOnline:

Anakinra Anakinra
Pronouncation: (an-a-KIN-ra) Class: Immunomodulator Trade Names: Kineret - Solution 100 mg per 0.67 mL Mechanism of Action Pharmacology Blocks the biologic activity of interleukin-1 (IL-1) by competitively inhibiting IL-1 binding to IL-1 type I receptor, which is expressed in a wide variety of orga more...

aspirin and hydrocodone aspirin and hydrocodone
Generic Name: aspirin and hydrocodone (AS pir in/hye droe KOE done) Brand Names: Alor 5/500, Azdone, Damason-P, Lortab ASA, Panasal 5/500 What is aspirin and hydrocodone? Hydrocodone (related to codeine) is in a class of drugs called narcotic analgesics. It is a pain reliever. Aspirin is more...

Chloroptic Chloroptic
Generic Name: chloramphenicol ophthalmic (klor am FEN i kole) Brand Names: Chloroptic, Chloroptic S.O.P. What is Chloroptic (chloramphenicol ophthalmic)? Chloramphenicol is an antibiotic. The ophthalmic form of chloramphenicol is used to treat bacterial infections of the eyes. Chloramph more...

Chlorthalidone Chlorthalidone
Pronouncation: (klor-THAL-ih-dohn) Class: Thiazide diuretic Trade Names: Chlorthalidone - Tablets 25 mg - Tablets 50 mg - Tablets 100 mg Trade Names: Thalitone - Tablets 15 mg Apo-Chlorthalidone (Canada) Mechanism of Action Pharmacology Inhibits reabsorption of sodium and chloride in proximal porti more...

Flovent Flovent
Generic name: Brand names: Flovent Rotadisk, Flovent, Flovent Diskus, Flonase, Fluticasone Why is Flovent prescribed? Flonase nasal spray is a remedy for the stuffy, runny, itchy nose that plagues many allergy-sufferers. It can be used either for seasonal attacks of hay fever or for year-round more...

Isotein HN Isotein HN
Some commonly used brand names are: In the U.S.— Accupep HPF 9 Advera 2 Alitraq 9 Amin-Aid 2 Attain 10 Carnation Instant Breakfast 7 Carnation Instant Breakfast No Sugar Added 7 Casec 8 CitriSource 10 Compleat Modified 1 Compleat Regular 1 Comply 10 Criticare HN 9 Crucial 2 Deliver 2.0 10 more...

Pacerone Pacerone
Generic Name: amiodarone (a mee OH da rone) Brand Names: Cordarone, Pacerone What is Pacerone (amiodarone)? Amiodarone is an antiarrhythmic medication that affects the rhythm of heartbeats. Amiodarone is used to help keep the heart beating normally in people with life-threatening heart more...

Procainamide hydrochloride Procainamide hydrochloride
Generic name: Procainamide hydrochloride Brand names: Pronestyl Pronestyl-SR, Procanbid Why is Procainamide hydrochloride prescribed? Procanbid is used to treat severe irregular heartbeats (arrhythmias). Arrhythmias are generally divided into two main types: heartbeats that are faster than norm more...