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All about: Inspra

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Generic Name: eplerenone (eh PLEH reh none)
Brand Names: Inspra

What is Inspra (eplerenone)?

Eplerenone blocks the actions of the hormone aldosterone in the body. Aldosterone is important for the regulation of blood pressure.

Eplerenone is used to lower high blood pressure. Eplerenone is also used in the treatment of congestive heart failure following a heart attack.

Eplerenone may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Inspra (eplerenone)?

Do not use salt substitutes or take potassium supplements while taking eplerenone except under the direction of your doctor.

What should I discuss with my healthcare provider before taking Inspra (eplerenone)?

Do not take eplerenone without first talking to your doctor if you
  • have a high level of potassium in the blood;

  • have type II diabetes (noninsulin dependent) with microalbuminuria (protein in the urine);

  • have kidney disease;
  • are using a salt substitute or taking a potassium supplement (e.g., K-Dur, Klor-Con) or a potassium-sparing diuretic such as amiloride (Midamor), triamterene (Dyrenium, Dyazide, Maxzide), or spironolactone (Aldactone); or

  • take other medicines.

You may not be able to take eplerenone or you may require a dosage adjustment or special monitoring if you have any of the conditions listed above.

Before taking eplerenone, tell your doctor if you have liver disease. You may require a dosage adjustment or special monitoring during treatment. Eplerenone is in the FDA pregnancy category B. This means that eplerenone is not expected to be harmful to an unborn baby. Do not take eplerenone without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether eplerenone passes into breast milk. Do not take eplerenone without first talking to your doctor if you are breast-feeding a baby.

How should I take Inspra (eplerenone)?

Take eplerenone exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water.

Eplerenone can be taken with or without food.

It is important to take eplerenone regularly to get the most benefit.

Do not stop taking eplerenone without first talking to your doctor, even if you are feeling well. Stopping suddenly could make your condition worse.

Your doctor may want to perform blood tests to monitor potassium levels in the body or perform other monitoring tests during treatment with eplerenone.

Store eplerenone at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose.

What happens if I overdose?

Seek emergency medical attention if an overdose is suspected. Symptoms of an eplerenone overdose may include vomiting, tremors, drowsiness and seizures.

What should I avoid while taking Inspra (eplerenone)?

Do not use salt substitutes or take potassium supplements while taking eplerenone except under the direction of your doctor.

This drug side effects

If you experience any of the following serious side effects, stop taking eplerenone and seek emergency medical treatment or contact your doctor immediately:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or

  • increased levels of potassium in the blood (nausea, diarrhea, or weakness may be early signs or it may be detected by blood tests).

If you experience any of the following less serious side effects, continue taking eplerenone and talk to your doctor:

  • headache;

  • dizziness;

  • fatigue; or

  • cough.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Inspra (eplerenone)?

Do not take eplerenone without first talking to your doctor if you are taking any of the following drugs:
  • a potassium supplement such as K-Dur, Klor-Con, and others;

  • a salt substitute that contains potassium;

  • a potassium-sparing diuretic (water pill) such as triamterene (Dyrenium, Maxzide, Dyazide), spironolactone (Aldactone), or amiloride (Midamor);

  • an angiotensin converting enzyme (ACE) inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik);

  • an angiotensin II receptor inhibitor such as candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), or valsartan (Diovan);

  • fluconazole (Diflucan), ketoconazole (Nizoral), or itraconazole (Sporanox);

  • verapamil (Calan, Covera-HS, Isoptin, Verelan);

  • erythromycin (E.E.S., E-Mycin, Ery-Tab, Eryc, PCE, others);

  • lithium (Lithobid, Eskalith, others);

  • nefazodone (Serzone);

  • a protease inhibitor such as amprenavir (Agenerase), ritonavir (Norvir, Kaletra), nelfinavir (Viracept), saquinavir (Fortovase, Invirase), or indinavir (Crixivan); or

  • delavirdine(Rescriptor).

You may not be able to take eplerenone, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with eplerenone or affect your condition. Talk to your doctor or pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Where can I get more information?

  • Your pharmacist has additional information about eplerenone written for health professionals that you may read.

What does my medication look like?

Eplerenone is available with a prescription under the brand name Inspra. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Inspra 25 mg-yellow, diamond-shaped, film-coated tablets

  • Inspra 50 mg-pink, diamond-shaped, film-coated tablets

  • Inspra 100 mg-red, diamond-shaped, film-coated tablets

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others and use this medication only for the condition prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 3.01. Revision Date: 3/12/04 11:16:06 AM.

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