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All about: Amikin

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Generic Name: Amikacin (am-i-KAY-sin)
Brand Name: Amikin

Amikin has caused kidney problems, nerve damage, and permanent hearing loss, even at usual doses. Hearing loss can occur even after the medicine is stopped. If you already have kidney problems or hearing difficulty, tell your doctor. Notify your doctor immediately if any of the following occur: ringing in the ears, hearing loss, unusual change in the amount of urine, dizziness, numbness, skin tingling, muscle twitching, or seizures. Amikin may be stopped by your doctor if you develop kidney or hearing problems. Your doctor will monitor your progress to minimize the possibility of these effects occurring and may run certain tests (eg, hearing and/or kidney tests). Do not use Amikin with other medicines that can cause nerve, kidney, or hearing problems. Other factors that increase the risk of these side effects occurring include advanced age or dehydration (unusual thirst).

Amikin is used for:

Treating certain serious bacterial infections.

Amikin is an aminoglycoside antibiotic. It works by inhibiting the production of bacterial proteins, which causes bacterial cell death.

Do NOT use Amikin if:

  • you are allergic to any ingredient in Amikin or other aminoglycoside antibiotics (eg, gentamicin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Amikin :

Some medical conditions may interact with Amikin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have hearing difficulty, nerve damage, severe muscle weakness (myasthenia gravis), Parkinson disease, or kidney problems, or you are dehydrated

Some MEDICINES MAY INTERACT with Amikin . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anesthetics (eg, succinylcholine) or neuromuscular blockers (eg, tubocurarine) because severe muscle relaxation progressing to paralysis and lack of breathing may occur
  • Amphotericin B, bacitracin, cephalosporins (eg, cephaloridine), cisplatin, colistin, loop diuretics (eg, furosemide), nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), other aminoglycosides (eg, gentamicin), polymyxin B, or vancomycin because the risk of kidney damage or hearing loss may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Amikin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Amikin :

Use Amikin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Amikin is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using Amikin at home, carefully follow the injection procedures taught to you by your health care provider.
  • If Amikin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Do not mix penicillin antibiotics (eg, ampicillin) in the same container or administer at the same time as Amikin .
  • Drinking extra fluids while you are taking Amikin is recommended. Check with your doctor or nurse for instructions.
  • To clear up your infection completely, continue using Amikin for the full course of treatment even if you feel better in a few days. Do not miss any doses.
  • Keep this product, as well as syringes and needles, out of the reach of children. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor, nurse, or pharmacist to explain local regulations for proper disposal.
  • If you miss a dose of Amikin , use it as soon as possible. Check with your doctor, nurse, or pharmacist for instructions on scheduling other doses.

Ask your health care provider any questions you may have about how to use Amikin .

Important safety information:

  • Some of these products contain sulfites, which can cause allergic reactions in certain individuals (eg, asthma patients). If you have previously had allergic reactions to sulfites, contact your pharmacist to determine if the product you are taking contains sulfites.
  • Amikin is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold).
  • It is important to use Amikin for the full course of treatment. Failure to do so may decrease the effectiveness of Amikin and may increase the risk that the bacteria will no longer be sensitive to Amikin and will not be able to be treated by this or certain other antibiotics in the future.
  • Long-term or repeated use of Amikin may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Amikin .
  • LAB TESTS, including hearing and kidney tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: Amikin has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Amikin during pregnancy. It is unknown if Amikin is excreted in breast milk. Do not breast feed while taking Amikin .

Possible side effects of Amikin :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breathing difficulty; loss of balance.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased urination; dizziness; hearing loss; lightheadedness; muscle weakness; numbness or tingling; ringing or roaring in the ears; vaginal irritation or discharge.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Amikin :

Store Amikin at 68 to 77 degrees F (20 to 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Amikin out of the reach of children and away from pets.

General information:

  • If you have any questions about Amikin , please talk with your doctor, pharmacist, or other health care provider.
  • Amikin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Amikin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition
Copyright © 2007 Wolters Kluwer Health, Inc.

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