23 . September , 2018 - Sunday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Lansoprazole/Naproxen

Big Image Pronouncation: (lan-SOE-pra-zole/na-PROX-en)
Class: Non-narcotic analgesic combination

Trade Names:
Prevacid NapraPAC 500
- Tablets 15 mg lansoprazole/500 mg naproxen

Mechanism of Action



Suppresses gastric acid secretion by blocking acid (proton) pump within gastric parietal cells.


Decreases inflammation, pain, and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Indications and Usage

For reducing the risk of NSAID-associated gastric ulcers in patients with a history of documented gastric ulcers who need an NSAID for treatment of signs and symptoms of rheumatoid arthritis, osteoarthritis, and/or ankylosing spondylitis.


Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery; aspirin- or NSAID-related asthma, urticaria, or allergic-type reactions; hypersensitivity to any component of the product.

Dosage and Administration


PO Lansoprazole 15 mg once daily and naproxen 500 mg twice daily. The naproxen dose and frequency may be adjusted to meet the patient's needs.

General Advice

  • In the morning before eating, administer lansoprazole 15 mg and one naproxen 500 mg tablet. In the evening, administer the second naproxen 500 mg tablet.
  • Swallow lansoprazole capsules whole; do not crush or chew.


Store at 59° to 86°F. Protect from light and moisture.

Drug Interactions

ACE inhibitors, beta-blockers

Antihypertensive effect may be decreased by naproxen.


Risk of serious GI complications, including bleeding, may be increased.

Diuretics (eg, loop diuretics [eg, furosemide], thiazide diuretics [eg, hydrochlorothiazide])

Diuretic effect may be reduced.

Drugs in which gastric pH is an important determinant of bioavailability (eg, ampicillin esters, digoxin, iron salts, ketoconazole)

Absorption may be altered by lansoprazole (eg, absorption of digoxin increased and ketoconazole decreased).


Lithium levels may be elevated, increasing the risk of toxicity.


Naproxen plasma levels may be elevated and the t ½ may be prolonged.


Take lansoprazole at least 30 min prior to sucralfate.


Cl may be increased slightly.

Laboratory Test Interactions

Naproxen may falsely increase urinary 17-ketosteroid values; may interfere with urinary assays for 5-hydroxy-indolacetic acid, decrease platelet aggregation, and prolong bleeding times.

Adverse Reactions


Dizziness, drowsiness, headache, light-headedness, vertigo (1% to 10%); abnormal dreams, aseptic meningitis, cognitive dysfunction, depression, insomnia, malaise, speech disorder (postmarketing).


Edema, palpitations (1% to 10%); CHF, vasculitis (postmarketing).


Ecchymosis, pruritus, purpura, skin eruptions, sweating (1% to 10%); alopecia, erythema multiforme, photosensitivity (including cases resembling porphyria cutanea tarda), skin rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria (postmarketing).


Hearing disturbances, tinnitus, visual disturbances (1% to 10%); hearing impairment (postmarketing).


Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, GI ulcers, gross bleeding/perforation, heartburn, nausea, stomatitis, vomiting (1% to 10%); colitis, hematemesis, nonpeptic ulceration, pancreatitis, ulcerative stomatitis (postmarketing).


Glomerular nephritis, hematuria, interstitial nephritis, menstrual disorder, nephrotic syndrome, renal disease, renal failure, renal papillary necrosis, urinary retention (postmarketing).


Agranulocytosis, aplastic anemia, eosinophilia, granulocytopenia, hemolytic anemia, leukopenia, melena, neutropenia, pancytopenia, thrombocytopenia, thrombotic thrombocytopenic purpura (postmarketing).


Abnormal LFTs, hepatotoxicity, jaundice (postmarketing).


Hyperglycemia, hyperkalemia, hypoglycemia (postmarketing).


Muscle weakness, myalgia, myositis (postmarketing).


Dyspnea (1% to 10%); eosinophilic pneumonitis (postmarketing).


Thirst (1% to 10%); anaphylactic reactions, angioneurotic edema, pyrexia (postmarketing).



NSAIDs may cause an increased risk of serious CV thrombotic events, MI, and stroke, which can be fatal. This risk may increase with length of therapy. Patients with CV disease or risk factors for CV disease may be at greater risk. Naproxen is contraindicated for the treatment of perioperative pain in the setting of CABG surgery. NSAIDs cause an increased risk of serious GI adverse reactions, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These reactions can occur any time during use and without warning symptoms. Elderly patients are at greater risk of serious GI reactions.


Determine hemoglobin values periodically in patients with an initial hemoglobin value of 10 g or less who receiving long-term therapy.


Category C . Avoid use in late pregnancy; may cause premature ductus arteriosus closure.



Excreted in breast milk.




Safety and efficacy not established.

Renal Function

Naproxen-containing products are not recommended in patients with moderate to severe and severe renal function impairment (Ccr less than 30 mL/min).

Hepatic Function

Consider dosage adjustments for the naproxen component in elderly patients and patients with liver disease.

Special Risk Patients

Use with caution in elderly patients or patients with fluid retention, hypertension, heart failure, or history of GI bleeding or ulcer disease.


Bleeding time may be prolonged as a result of inhibition of platelet aggregation.

Concomitant therapy

Do not use naproxen sodium with other naproxen-containing drugs because they all will circulate as naproxen anion.


Onset of new hypertension or worsening of preexisting hypertension may occur, increasing the risk of CV events.

Inflammatory conditions

Because fever and inflammation may be reduced by naproxen, signs used in diagnosing complications of presumed noninfectious, noninflammatory painful conditions may be diminished.

Renal effects

Long-term administration may result in renal injury, including renal papillary necrosis.



Abdominal discomfort, acute renal failure, alterations in liver function, anaphylactoid reactions, apnea, coma, disorientation, dizziness, drowsiness, epigastric pain, GI bleeding, heartburn, hypertension, hypoprothrombinemia, indigestion, lethargy, metabolic acidosis, nausea, renal function impairment, respiratory depression, seizures, vomiting.

Patient Information

  • Advise patient to read the Medication Guide before starting therapy and with each refill.
  • Instruct patient to take lansoprazole 15 mg and one naproxen 500 mg tablet in the morning before eating and to take the second naproxen 500 mg tablet in the evening.
  • Instruct patient to promptly report signs or symptoms of unexplained weight gain or edema to health care provider.
  • Instruct patient of the warning signs and symptoms of hepatotoxicity and to stop therapy and seek immediate medical attention if they occur.
  • Instruct patients to seek immediate medical assistance if they experience difficulty breathing and/or swelling of the face or throat.
  • Caution patient to avoid taking this medication in late pregnancy because of risk of premature closure of the ductus arteriosus.
  • Advise patients to use caution when engaging in activities requiring alertness if they experience drowsiness, dizziness, vertigo, or depression during therapy.

Recent Drug Updates at DrugIndexOnline:

black haw black haw
Generic Name: black haw (black HA) Brand Names: What is black haw? The use of black haw in cultural and traditional settings may differ from concepts accepted by current Western medicine. When considering the use of herbal supplements, consultation with a primary health care professiona more...

Cefzil Cefzil
Generic Name: Cefprozil Tablets (sef-PROE-zil) Brand Name: CefzilCefzil is used for:Treating mild to moderate infections caused by certain bacteria. Cefzil is a cephalosporin antibiotic. It works by interfering with the formation of the bacteria's cell wall while it is growing. This causes the more...

Dormarex 2 Dormarex 2
Some commonly used brand names are: In the U.S.— Alavert 14 Allegra 12 Aller-Chlor 4 AllerMax Caplets 10 Aller-med 10 Atarax 13 Banophen 10 Banophen Caplets 10 Benadryl 10 Benadryl Allergy 10 Bromphen 2 Calm X 9 Chlo-Amine 4 Chlorate 4 Chlor-Trimeton 4 Chlor-Trimeton Allergy 4 Chlor-Trime more...

Foamicon Foamicon
Some commonly used brand names are: In the U.S.— Advanced Formula Di-Gel 29 Alamag 2 Alamag Plus 9 Alenic Alka 15 Alenic Alka Extra Strength 18 Alka-Mints 27 Alkets 27 Alkets Extra Strength 27 Almacone 9 Almacone II 9 AlternaGEL 21 Alu-Cap 25 Aludrox 9 Alu-Tab 25 Amitone 27 Amphojel 25 An more...

Lithium carbonate Lithium carbonate
Generic name: Lithium carbonate Brand names: Eskalith CR Lithobid, Eskalith Why is Lithium carbonate prescribed? Eskalith is used to treat the manic episodes of manic-depressive illness, a condition in which a person's mood swings from depression to excessive excitement. A manic episode may invo more...

Lobana Peri-Garde topical Lobana Peri-Garde topical
Generic Name: vitamins A, D, and E (topical) (VY ta mins A, D, and E) Brand Names: Aloe Grande, Lazer Creme, Lobana Derm-Ade, Lobana Peri-Garde What is vitamin A, D, and E topical? Vitamin A, D, and E topical is a skin protectant. It works by moisturizing and sealing the skin, and aids more...

Metolazone Metolazone
Generic name: Metolazone Brand names: Zaroxolyn, Mykrox Why is Metolazone prescribed? Zaroxolyn is a diuretic used in the treatment of high blood pressure and other conditions that require the elimination of excess fluid from the body. These conditions include congestive heart failure and kidney more...

Paradione Paradione
Generic Name: paramethadione (pare ah meth ah DYE own) Brand Names: Paradione What is Paradione (paramethadione)? Paramethadione is a seizure medication. The exact way that it works is unknown. Paramethadione is used to control absence ("petit mal") seizures. Paramethadione may also be more...