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All about: laronidase

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Generic Name: laronidase (lah RAH nih daze)
Brand Names: Aldurazyme

What is laronidase?

Laronidase is a man-made form of the naturally-occurring enzyme alpha-L-iduronidase. A deficiency of the enzyme alpha-L-iduronidase is called mucopolysaccharidosis I (MPS I). Laronidase helps the body break down certain products that may lead to damage in the tissues and organs.

Laronidase is used in the treatment of mucopolysaccharidosis disease.

Laronidase may also be used for purposes other than those listed here.

What is the most important information I should know about laronidase?

Symptoms of allergic or infusion reactions including difficulty breathing; closing of the throat; hives; rash; itching; low blood pressure; and dizziness; have occurred upon injection of laronidase in a small number of patients. A slow rate of injection of the medication and pretreatment with other medications may decrease the severity of these symptoms, should they occur. Contact your doctor immediately if you develop any symptoms of an allergic reaction during or soon after an injection of laronidase.

What should I discuss with my healthcare provider before using laronidase?

Before using laronidase, tell your doctor if you have other medical conditions, if you take other prescription or over-the-counter medicines including vitamins, minerals, and herbal products, or if you have ever had an allergic reaction to laronidase, another medication, foods, dyes, or preservatives in the past. You may not be able to use laronidase, or you may require a dosage adjustment or special monitoring during treatment.

Laronidase is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby. Do not use laronidase without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether laronidase passes into breast milk. Do not use laronidase without first talking to your doctor if you are breast-feeding a baby.

How should I use laronidase?

Use laronidase exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Laronidase is given by intravenous (into the vein) injection and will most likely be administered by a healthcare provider.

Your doctor may prescribe other medications to be taken before receiving the laronidase injection. These may help prevent or reduce the severity of an allergic or infusion reaction. Take these medications as directed by your healthcare provider.

Your doctor may want you to have blood tests or other medical evaluations during treatment with laronidase to monitor progress and side effects.

Your healthcare provider will store laronidase as instructed by the manufacturer. If you are storing laronidase at home, your healthcare provider will give you instructions regarding how to store the medication.

What happens if I miss a dose?

Contact your doctor if you miss a dose of laronidase.

What happens if I overdose?

Contact your doctor, a hospital emergency room, or a poison control center if an overdose is suspected.

Although symptoms of an laronidase overdose are not known, an overdose is unlikely to threaten life.

What should I avoid while taking laronidase?

There are no restrictions on food, beverages, or activity during treatment with laronidase.

Laronidase side effects

Symptoms of allergic or infusion reactions including difficulty breathing; closing of the throat; hives; rash; itching; low blood pressure; and dizziness; have occurred upon injection of laronidase in a small number of patients. A slow rate of injection of the medication and pretreatment with other medications may decrease the severity of these symptoms, should they occur. Contact your doctor immediately if you develop any symptoms of an allergic reaction during or soon after an injection of laronidase.

Other less serious side effects such as flushing and redness, pain or swelling at the injection site may be more likely to occur following injection of laronidase. Talk to your doctor about any side effects that you experience.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect laronidase?

Laronidase is not known to interact with other medications. Talk to your doctor or pharmacist before taking other prescription or over-the-counter medications, including vitamins, minerals, and herbal products, during treatment with laronidase.

Where can I get more information?

  • Your pharmacist has more information about laronidase written for health professionals that you may read.

What does my medication look like?

Laronidase is available with a prescription under the brand name Aldurazyme. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.02. Revision Date: 2/13/04 4:09:48 PM.

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