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All about: Lisinopril/Hydrochlorothiazide

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Generic Name: Lisinopril/Hydrochlorothiazide (lie-SIN-oh-prill/high-droe-klor-oh-THIGH-uh-zide)
Brand Name: Examples include Prinzide and Zestoretic

This drug can cause serious fetal harm and possibly fetal death if used during the last 6 months of pregnancy. If you become pregnant, stop using Lisinopril/Hydrochlorothiazide and immediately contact your doctor.


Lisinopril/Hydrochlorothiazide is used for:

Lowering high blood pressure.

Lisinopril/Hydrochlorothiazide is an angiotensin-converting enzyme (ACE) inhibitor and thiazide diuretic combination. It works to lower your blood pressure by removing excess fluid from the body and causing blood vessels to relax or widen.

Do NOT use Lisinopril/Hydrochlorothiazide if:

  • you are allergic to any ingredient in Lisinopril/Hydrochlorothiazide or any other sulfonamide medicine (eg, sulfamethoxazole, glyburide, probenecid)
  • you have a history of angioedema (swelling of the face, lips, throat, or tongue)
  • you have a history of kidney artery narrowing
  • you are unable to urinate
  • you are taking dofetilide or ketanserin
  • you are in your second or third trimester of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lisinopril/Hydrochlorothiazide :

Some medical conditions may interact with Lisinopril/Hydrochlorothiazide . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have giant hives or skin inflammation, impaired liver function, diabetes, bone marrow suppression, blood vessel problems of the brain (eg, stroke), gout, high blood potassium levels, low blood sodium levels, heart disease, scleroderma, severe immune system problems, or lupus, or you are on a sodium restricted diet
  • if you have a history of allergies or asthma
  • if you are scheduled to have major surgery or to receive anesthesia
  • if you have a history of kidney artery narrowing, decreased kidney function, you are on dialysis, or you have had a kidney transplant

Some MEDICINES MAY INTERACT with Lisinopril/Hydrochlorothiazide . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Celecoxib or salicylates (eg, aspirin) because they may decrease Lisinopril/Hydrochlorothiazide 's effectiveness
  • ACE inhibitors (eg, enalapril), indomethacin, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), or thiazide diuretics (eg, hydrochlorothiazide) because side effects, such as increased risk for kidney dysfunction, may occur
  • Barbiturates (eg, phenobarbital), dextran sulfate, diazoxide, or narcotic pain medicine (eg, codeine) because side effects, such increased risk for low blood pressure, may occur
  • Corticosteroids (eg, prednisone), digitalis glycosides (eg, digoxin), dofetilide, ketanserin, lithium, muscle relaxants (eg, methocarbamol), potassium preparations, potassium-sparing diuretics (eg, triamterene), or thiopurines (eg, azathiopurine) because the risk of their side effects may be increased by Lisinopril/Hydrochlorothiazide
  • Insulin, sulfonylureas (eg, glyburide), or other medicines for diabetes because their effectiveness may be decreased by Lisinopril/Hydrochlorothiazide

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lisinopril/Hydrochlorothiazide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lisinopril/Hydrochlorothiazide :

Use Lisinopril/Hydrochlorothiazide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Lisinopril/Hydrochlorothiazide by mouth with or without food.
  • If you take cholestyramine or colestipol, ask your doctor or pharmacist how to take it with Lisinopril/Hydrochlorothiazide .
  • Take Lisinopril/Hydrochlorothiazide on a regular schedule to get the most benefit from it.
  • Taking Lisinopril/Hydrochlorothiazide at the same time each day will help you remember to take it.
  • Continue to use Lisinopril/Hydrochlorothiazide even if you feel well. Do not miss any doses.
  • If you miss a dose of Lisinopril/Hydrochlorothiazide , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Lisinopril/Hydrochlorothiazide .

Important safety information:

  • Lisinopril/Hydrochlorothiazide may cause dizziness, lightheadedness, or fainting. These effects may be worse if you take it with alcohol or certain medicines. Use Lisinopril/Hydrochlorothiazide with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Lisinopril/Hydrochlorothiazide may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Drink plenty of fluids while taking Lisinopril/Hydrochlorothiazide and avoid engaging in activities that cause excessive sweating. Dehydration, excessive sweating, vomiting, or diarrhea may lead to a fall in blood pressure. Contact your health care provider at once if any of these occur.
  • Diabetes patients - Lisinopril/Hydrochlorothiazide may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • A persistent, unproductive cough may occur. Tell your doctor if this occurs. Recovery is rapid when the medicine is stopped.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Lisinopril/Hydrochlorothiazide may not work as well in black patients. They may also be at greater risk of side effects. Contact your doctor if your symptoms do not improve or if they become worse.
  • Tell your doctor or dentist that you take Lisinopril/Hydrochlorothiazide before you receive any medical or dental care, emergency care, or surgery.
  • Lisinopril/Hydrochlorothiazide may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Lisinopril/Hydrochlorothiazide . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Lab tests, including blood electrolytes, blood pressure, and kidney function, may be performed while you use Lisinopril/Hydrochlorothiazide . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Lisinopril/Hydrochlorothiazide with caution in the ELDERLY; they may be more sensitive to its effects.
  • Lisinopril/Hydrochlorothiazide should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Lisinopril/Hydrochlorothiazide may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Lisinopril/Hydrochlorothiazide is found in breast milk. Do not breast-feed while taking Lisinopril/Hydrochlorothiazide .

Possible side effects of Lisinopril/Hydrochlorothiazide :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Coughing; diarrhea; dizziness; headache; lightheadedness; nausea; persistent nonproductive cough; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty swallowing; fainting; fast, slow, or irregular heartbeat; fever; hoarseness; increased hunger or thirst; muscle cramps; muscle weakness; severe dizziness or lightheadedness; shortness of breath; sore throat; unusual or severe drowsiness; unusual stomach pain; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include dizziness; fainting; weakness.

Proper storage of Lisinopril/Hydrochlorothiazide :

Store Lisinopril/Hydrochlorothiazide at 77 degrees F (25 degrees C) in a tightly closed container. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Keep Lisinopril/Hydrochlorothiazide out of the reach of children and away from pets.

General information:

  • If you have any questions about Lisinopril/Hydrochlorothiazide , please talk with your doctor, pharmacist, or other health care provider.
  • Lisinopril/Hydrochlorothiazide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Lisinopril/Hydrochlorothiazide . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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