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All about: Lodine

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Generic name: Etodolac
Brand names: Lodine

Why is Lodine prescribed?

Lodine, a nonsteroidal anti-inflammatory drug, is available in regular and extended-release forms (Lodine XL). Both forms are used to relieve the inflammation, swelling, stiffness, and joint pain of osteoarthritis (the most common form of arthritis) and rheumatoid arthritis. Regular Lodine is also used to relieve pain in other situations.

Most important fact about Lodine

You should have frequent checkups with your doctor if you take Lodine regularly. Ulcers or internal bleeding can occur without warning.

How should you take Lodine?

Your doctor may ask you to take Lodine with food or an antacid, and with a full glass of water. Never take it on an empty stomach.

Take Lodine exactly as prescribed by your doctor.

You should see results in 1 to 2 weeks.

If you are using Lodine for arthritis, it should be taken regularly.

--If you miss a dose...

Take the forgotten dose as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule. Never try to "catch up" by doubling the dose.

--Storage instructions...

Store at room temperature. Protect capsules from moisture. Protect Lodine tablets from light; protect Lodine XL tablets from excessive heat and humidity.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Lodine.

  • More common side effects may include:
    Abdominal pain, black stools, blurred vision, chills, constipation, depression, diarrhea, dizziness, fever, gas, increased frequency of urination, indigestion, itching, nausea, nervousness, rash, ringing in ears, painful or difficult urination, vomiting, weakness

Why should Lodine not be prescribed?

If you are sensitive to or have ever had an allergic reaction to Lodine, or if you have had asthma attacks, hives, or other allergic reactions caused by aspirin or other nonsteroidal anti-inflammatory drugs such as Motrin, you should not take Lodine; it might cause a severe allergic reaction. Make sure your doctor is aware of any drug reactions you have experienced; and be careful about taking Lodine if you have asthma--even if you've never had a drug reaction before. If you do suffer an allergic reaction, call for emergency help immediately.

Special warnings about Lodine

Peptic ulcers and bleeding can occur without warning. You may have other problems with bleeding as well.

Call your doctor if you have any signs or symptoms of stomach or intestinal ulcers or bleeding, blurred vision or other eye problems, skin rash, weight gain, or fluid retention and swelling.

This drug should be used with caution if you have kidney or liver disease; and it can cause liver inflammation in some people.

Do not take aspirin or any other anti-inflammatory medications while taking Lodine, unless your doctor tells you to do so.

If you are taking Lodine over an extended period of time, your doctor should check your blood for anemia.

This drug can increase water retention. Use with caution if you have heart disease or high blood pressure.

Possible food and drug interactions when taking Lodine

If Lodine is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Lodine with the following:

Aspirin
Cyclosporine (Sandimmune, Neoral)
Digoxin (Lanoxin)
Lithium (Lithobid, others)
Methotrexate
Phenylbutazone (Butazolidin)
The blood-thinning drug warfarin (Coumadin)

Special information if you are pregnant or breastfeeding

The effects of Lodine during pregnancy have not been adequately studied. However, you should definitely not take it in late pregnancy. If you are pregnant or plan to become pregnant, inform your doctor immediately. Lodine may appear in breast milk and could affect a nursing infant. If Lodine is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with Lodine is finished.

Recommended dosage

ADULTS

General Pain Relief

Take 200 to 400 milligrams every 6 to 8 hours as needed. Ordinarily, you should not take more than 1,000 milligrams a day, although your doctor may increase the dose to 1,200 milligrams a day if absolutely necessary.

Osteoarthritis and Rheumatoid Arthritis

The starting dose of Lodine is 300 milligrams 2 or 3 times a day, or 400 or 500 milligrams twice a day. The usual daily maximum ranges from 600 to 1,000 milligrams, although your doctor may prescribe as much as 1,200 milligrams a day if necessary.

The usual dose of Lodine XL is 400 to 1,200 milligrams taken once a day.

Your doctor will stick with the lowest dose that proves effective.

CHILDREN

The safety and effectiveness of Lodine have not been established in children.

Overdosage

Any medication taken in excess can cause symptoms of overdose. If you suspect an overdose, seek medical attention immediately.

  • Symptoms of Lodine overdose may include:
    Drowsiness, lethargy, nausea, stomach pain, vomiting

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