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All about: Loteprednol And Tobramycin

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Some commonly used brand names are:

In the U.S.—

  • Zylet

Not commercially available in Canada.


  • Anti-inflammatory, steroidal
  • corticosteroid, ophthalmic
  • antibacterial, ophthalmic


Loteprednol (loe-te-PRED-nol) and tobramycin (toe-bra-MYE-sin) is a combination of an antibiotic and a corticosteroid (kor-ti-ko-STER-oid). It is used in the eye to prevent permanent damage, which may occur with certain eye problems.

This medicine is available only with your doctor's prescription, in the following dosage forms:

  • Ophthalmic
  • Suspension (eye drops) (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For loteprednol and tobramycin, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to loteprednol or tobramycin. Also tell your doctor and pharmacist if you are allergic to any other substances, such as other corticosteroids or aminoglycosides.

Pregnancy—Loteprednol and tobramycin combination has not been studied in pregnant women. However, studies in animals have shown that loteprednol may cause unwanted effects. Before taking this medicine, make sure you doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—It is not known whether loteprednol and tobramycin combination passes into the breast milk. Loteprednol and tobramycin combination is not recommended during breast-feeding, because it may cause unwanted effects in nursing babies.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of loteprednol and tobramycin in children with use in other age groups.

Older adults—This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other medical problems—The presence of other medical problems may affect the use of loteprednol and tobramycin combination. Make sure you tell your doctor if you have any other medical problems, especially:

  • Cataract surgery—Use of loteprednol after cataract surgery may delay healing and increase the chance of side effects
  • Certain eye diseases that cause the cornea to get thin—Use of ophthalmic loteprednol could cause a hole to form (perforation)
  • Fungus infection of the eye or
  • Herpes infection of the eye or
  • Pussy conditions of the eye or
  • Virus infection of the eye or
  • Yeast infection of the eye—Ophthalmic loteprednol and tobramycin may mask or make existing infections worse.
  • Glaucoma—Prolonged use of corticosteroids may result in glaucoma; caution should be used when corticosteroids are used in patients who have glaucoma

Proper Use of This Medicine

Shake the container very well before applying the eye drops.

Using only if the imprinted neckband is intact.

Do not wear soft contact lenses while you are using this medicine. .

Decrease use gradually as symptoms improve.

To help clear up your eye infection completely, keep using loteprednol and tobramycin for the full time of treatment , even if your symptoms have disappeared.

To use:

  • First, wash your hands. Tilt your head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 1 or 2 minutes to allow the medicine to be absorbed by the eye.
  • If you think you did not get the drop of medicine into your eye properly, use another drop.
  • To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye) . Also, keep the container tightly closed.

Dosing—The dose of ophthalmic loteprednol and tobramycin will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of loteprednol and tobramycin. If your dose is different, do not change it unless your doctor tells you to do so.

  • For ophthalmic suspension dosage form (eye drops):
    • For eye disorders:
      • Adults—Use one or two drops into the affected eye every four to six hours. Your doctor may have you use the drops more frequently during the first day or two and will probably have you space the doses further apart as the eye gets better
      • Children—Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Store upright away from heat.
  • Keep the medicine from freezing.
  • Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

If you will be using this medicine for more than few weeks, an ophthalmologist (eye doctor) should examine your eyes at regular visits to make sure it does not cause unwanted effects.

If your eye infection does not improve or if your condition becomes worse, check with your doctor .

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Increased intraocular pressure; painful irritation of the clear front part of the eye

Less common

Blurred vision or blue-green halos seen around objects; blurred vision or other changes in vision; decreased vision; discharge from the eye; dry eyes; eyelid burning, redness, itching, pain, or tenderness; fast heartbeat; fever; hives; hoarseness; irritation and swelling of the eye; itching; joint pain; lid itching and swelling; pain in eye; rash; redness of skin; redness of eyelid; sensitivity of eyes to light; shortness of breath; stiffness or swelling; swelling of eyelids, face, lips, hands, or feet; tightness in chest; troubled breathing or swallowing; wheezing

Incidence not known

Redness of eye; tearing

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

More common

Burning; dry eyes; headache; increased sensitivity of eyes to light; itching; stinging

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Developed: 06/09/2005

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