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All about: Lovenox

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Generic Name: Enoxaparin (ee-nox-AP-a-rin)
Brand Name: Lovenox

Lovenox should be used with extreme caution in patients with a history of low blood platelets due to the use of heparin. Talk with your doctor about the bleeding risks associated with Lovenox .

Tell your doctor you are using Lovenox before undergoing any procedure involving a spinal puncture or spinal anesthesia. An epidural or spinal hematoma (a blood clot on or near the spinal cord) may develop if you have a spinal puncture or spinal anesthesia while using Lovenox . This could result in paralysis, which could be permanent. This risk is greater if you are taking other "blood thinning" medicines (eg, aspirin, clopidogrel, warfarin) or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen), or when certain medicine delivery devices (eg, an indwelling epidural catheter) are used.


Lovenox is used for:

Preventing blood clots in patients who have certain illnesses or who will be having certain types of surgery. It is also used along with other medicine to treat blood clots. It is used along with other medicine prevent certain problems caused by heart attack or unstable angina (chest pain). It is also used to decrease the risk of recurring heart attack in certain patients. It may also be used for other conditions as determined by your doctor.

Lovenox is a low molecular weight antithrombotic. It acts by inhibiting the reactions that lead to clotting of blood.

Do NOT use Lovenox if:

  • you are allergic to any ingredient in Lovenox
  • you are allergic to heparin or pork products
  • you have episodes of severe bleeding
  • you have severe or uncontrolled high blood pressure
  • you are taking a salicylate (eg, aspirin) or an NSAID (eg, ibuprofen, naproxen)
  • you have a low platelet count and the presence of antiplatelet antibodies

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lovenox :

Some medical conditions may interact with Lovenox . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are allergic to benzyl alcohol
  • if you have blood platelet problems, bleeding problems, a blood disease, heart problems, stomach problems, liver or kidney problems, low body weight, or vision problems caused by diabetes, or if you have had recent surgery (especially brain, spinal, or eye surgery)
  • if you have a history of low platelet counts after taking heparin
  • if you have recently given birth

Some MEDICINES MAY INTERACT with Lovenox . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nitrates (eg, nitroglycerin, isosorbide dinitrate) or streptokinase because they may decrease Lovenox 's effectiveness
  • Activated protein C, cephalosporins (eg, cephalexin),NSAIDs (eg, ibuprofen, naproxen), penicillins, orsalicylates (eg, aspirin) because side effects, such as increased bleeding, may occur
  • Activated protein C or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Lovenox

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lovenox may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lovenox :

Use Lovenox as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Lovenox is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Lovenox at home, a health care provider will teach you how to use it. Be sure you understand how to use Lovenox . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into muscle.
  • Do not use Lovenox if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Lovenox , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Lovenox .

Important safety information:

  • Lovenox may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Tell your doctor or dentist that you take Lovenox before you receive any medical or dental care, emergency care, or surgery.
  • Some forms of Lovenox contain benzyl alcohol. Do not use medicine with benzyl alcohol in NEWBORNS or INFANTS. It may cause serious and sometimes fatal side effects. If you have questions, check with your doctor or pharmacist.
  • If you have ever had an allergic reaction to benzyl alcohol, ask your doctor or pharmacist if your medicine has benzyl alcohol in it.
  • Lab tests, including liver function, complete blood cell counts, and blood clotting time, may be performed while you use Lovenox . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Lovenox with caution in the ELDERLY; they may be more sensitive to its effects, especially bleeding.
  • Lovenox should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Lovenox may contain the preservative benzyl alcohol, which can cause harm to the fetus. If you become pregnant, use a formulation without this preservative. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Lovenox while you are pregnant. It is not known if Lovenox is found in breast milk. If you are or will be breast-feeding while you are using Lovenox , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Lovenox :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Confusion; diarrhea; mild pain; nausea; pain, swelling, redness, bleeding, or bruising at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody, black, or tarry stools; chills; difficulty urinating; difficulty walking; fever; leg weakness; numbness; pink or red urine; swelling; tingling; unusual bleeding or bruising.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include bruising; excessive bleeding.

Proper storage of Lovenox :

Store this medicine at room temperature, between 59 and 77 degrees F, (15 and 25 degrees C). Store away from heat, moisture, and light. Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Keep Lovenox out of the reach of children and away from pets.

General information:

  • If you have any questions about Lovenox , please talk with your doctor, pharmacist, or other health care provider.
  • Lovenox is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Lovenox . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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