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All about: lubiprostone

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Generic Name: lubiprostone (loo bee PROS tone)
Brand Names: Amitiza

What is lubiprostone?

Lubiprostone increases the secretion of fluid in your intestines to help make it easier to pass stools (bowel movements).

Lubiprostone is used to treat chronic constipation.

Lubiprostone may also be used for purposes other than those listed here.

What is the most important information I should know about lubiprostone?

Use this medication exactly as it was prescribed for you. Do not use it in larger doses or for longer than recommended by your doctor.

Do not take lubiprostone if you have severe diarrhea. Call your doctor for instructions.

If you miss a dose, use the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

There may be other drugs that can affect lubiprostone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Stop using this medication and get emergency medical help if you think you have used too much medicine, or if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects are more likely, and you may have none at all. Talk to your doctor about any side effect that seems unusual or is especially bothersome.

What should I discuss with my health care provider before taking lubiprostone?

Before using this medication, tell your doctor if you have a history of hernia, gallstones, Crohn's disease, Hirschsprung's disease, impacted bowel movement, diverticulitis, polyps, or any other cause for obstruction in your gastrointestinal (digestive) system.

If you have any of these conditions, you may not be able to use lubiprostone or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C: This medication may be harmful to an unborn baby. Do not use lubiprostone without telling your doctor if you are pregnant. You may be asked to have a pregnancy test before you start taking lubiprostone. Tell your doctor if you become pregnant during treatment. It is not known if lubiprostone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take lubiprostone?

Take lubiprostone exactly as it was prescribed for you. Do not take it in larger doses or for longer than recommended by your doctor.

Take lubiprostone with food. Do not take lubiprostone if you have severe diarrhea. Call your doctor for instructions. Store lubiprostone at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of a lubiprostone overdose may include vomiting, diarrhea, stomach pain, dizziness, hot flashes, trouble breathing, pale skin, or fainting.

What should I avoid while taking lubiprostone?

There are no restrictions on food, beverages, or activity while using lubiprostone unless your doctor tells you otherwise.

Lubiprostone side effects

Stop using lubiprostone and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have severe vomiting or diarrhea .

Less serious side effects are more likely to occur. Continue using lubiprostone and talk with your doctor if you have any of these less serious side effects:

  • nausea, vomiting, mild diarrhea, stomach pain or bloating;

  • runny or stuffy nose, sneezing, cough;

  • headache, dizziness;

  • swelling in your hands, ankles, or feet;

  • back pain; or

  • sore throat.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect lubiprostone?

There may be other drugs that can affect lubiprostone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist has more information about lubiprostone written for health professionals that you may read.

What does my medication look like?

Lubiprostone is available with a prescription under the brand name Amitiza. Other brand or generic forms may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Amitiza 24 mcg--orange, oval-shaped soft gelatin capsule

  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.01. Revision Date: 3/6/06 11:07:44 AM.

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