18 . February , 2018 - Sunday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Magaldrate (Hydroxymagnesium Aluminate)

Big Image ( Hydroxymagnesium Aluminate ) Pronouncation: (MAG-al-drate)
Class: Antacid

Trade Names:
Iosopan
- Liquid 540 mg/5 mL

Trade Names:
Riopan
- Suspension 540 mg/5 mL

Mechanism of Action

Pharmacology

Neutralizes gastric acid, thereby increasing pH of stomach and duodenal bulb. Increases lower esophageal sphincter tone and inhibits smooth muscle contraction and gastric emptying.

Indications and Usage

Symptomatic relief of upset stomach associated with hyperacidity, including heartburn, gastroesophageal reflux, acid indigestion and sour stomach; relief of hyperacidity associated with peptic ulcer, gastritis, peptic esophagitis, gastric hyperacidity and hiatal hernia.

Contraindications

Severe renal dysfunction; hypophosphatemia; nausea; vomiting; severe abdominal pain; acute surgical abdomen; impaction; intestinal obstruction.

Dosage and Administration

Adults

PO 480 to 1080 mg 4 times daily as needed or to aid in peptic ulcer healing or chronic reflux, give 1 h and 3 h after meals and at bedtime (7 doses/day).

Children

PO 5 to 10 mg/dose every 3 to 6 h or 1 h and 3 h after meals and at bedtime for peptic ulcer.

Storage/Stability

Store at room temperature (59° to 86°F).

Drug Interactions

Iron

Decreased pharmacologic effect of iron.

Ketoconazole

Decreased pharmacologic effect of ketoconazole.

Nitrofurantoin

Decreased effects of nitrofurantoin.

Penicillamine

Decreased pharmacologic effect of penicillamine.

Quinidine

Increased pharmacologic effect of quinidine.

Quinolones

Decreased pharmacologic effect of quinolones.

Salicylates

Decreased pharmacologic effect of salicylates.

Sodium polystyrene sulfonate

Concomitant use may cause metabolic alkalosis in patients with renal failure.

Tetracyclines

Decreased pharmacologic effect of tetracyclines.

Laboratory Test Interactions

None well documented.

Adverse Reactions

CNS

Neurotoxicity; encephalopathy.

GI

Diarrhea; constipation; intestinal obstruction; rebound hyperacidity.

Metabolic

Hypophosphatemia; hypermagnesemia.

Miscellaneous

Osteomalacia; bone pain; muscular weakness; malaise; decreased fluoride absorption; aluminum accumulation in serum, bone and CNS; milk-alkali syndrome.

Precautions

Pregnancy

Pregnancy category undetermined.

Lactation

Undetermined.

Renal Function

Use with caution in patients with renal function impairment to avoid hypermagnesemia and toxicity.

GI hemorrhage

Use with care in patients with recent massive upper GI hemorrhage.

Overdosage

Symptoms

Nausea, vomiting, diarrhea, constipation, hypermagnesemia, hypophosphatemia.

Patient Information

  • Instruct patient to take medication 1 and 3 h after meals and at bedtime.
  • Warn patient not to take other medications within 2 h of antacid.
  • Review proper use of suspension or tablet form.
  • Advise patient to consult health care provider if problem recurs, if any symptoms that suggest bleeding occur (eg, black, tarry stools) or if patient has taken antacids for more than 2 wk.

Recent Drug Updates at DrugIndexOnline:





Alocril Solution Alocril Solution
Generic Name: Nedocromil Ophthalmic Solution (ne-doe-KROE-mil) Brand Name: AlocrilAlocril Solution is used for:Treating itching associated with allergic conjunctivitis (pink eye). Alocril Solution is a mast cell stabilizer. It works by preventing the release of certain cells in the body that con more...

Cefadroxil Suspension Cefadroxil Suspension
Generic Name: Cefadroxil Suspension (SEFF-ah-DROX-il) Brand Name: DuricefCefadroxil Suspension is used for:Treating infections caused by certain bacteria. Cefadroxil Suspension is a cephalosporin antibiotic. It works by interfering with the bacteria's cell wall formation. This weakens the cell w more...

Chlorpheniramine, Pyrilamine, Phenylephrine, and Acetaminophen Chlorpheniramine, Pyrilamine, Phenylephrine, and Acetaminophen
Some commonly used brand names are: In the U.S.— Actifed Cold & Sinus Caplets 3 Alka-Seltzer Plus Cold Medicine Liqui-Gels 3 Benadryl Allergy/Sinus Headache Caplets 6 Children's Tylenol Cold Multi-Symptom 3 Comtrex Allergy-Sinus 3 Comtrex Allergy-Sinus Caplets 3 Contac Allergy/Sinus N more...

Eligard Suspension Eligard Suspension
Generic Name: Leuprolide 30 mg (4-month formulation) Subcutaneous Suspension (loo-PRO-lide) Brand Name: EligardEligard Suspension is used for:Treating symptoms of advanced prostate cancer. It may also be used for other conditions as determined by your doctor. Eligard Suspension is a gonadotropin more...

Glimepiride Glimepiride
Generic name: Glimepiride Brand names: Amaryl Why is Glimepiride prescribed? Amaryl is an oral medication used to treat type 2 (non-insulin-dependent) diabetes when diet and exercise alone fail to control abnormally high levels of blood sugar. Like other diabetes drugs classified as sulfonylurea more...

insulin inhalation insulin inhalation
Generic Name: insulin inhalation (IN soo lin in hel AY shun) Brand Names: EXUBERA What is insulin inhalation? Insulin inhalation is a rapid-acting form of human insulin that is inhaled through the mouth. It works by lowering levels of glucose (sugar) in the blood. Insulin inhalation is more...

Motofen Motofen
Some commonly used brand names are: In the U.S.— Motofen † Not commercially available in Canada. Category Antidiarrheal, antiperistaltic Description Difenoxin and atropine (dye-fen-OX-in and A-troe-peen) combination medicine is used along with other measures to treat sever more...

multivitamin with iron and fluoride multivitamin with iron and fluoride
Generic Name: multivitamin with iron and fluoride (mul tee VY ta min with EYE urn and FLOOR ide) Brand Names: Multi Vita Bets and Fluoride and Iron, Poly-Vi-Flor with Iron, Tri-Vi-Flor with Iron, Vi-Daylin/F Plus Iron What is multivitamin with iron and fluoride? Multivitamins pr more...