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All about: Maxzide

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Generic name: Hydrochlorothiazide, Triamterene
Brand names: Maxzide-25 MG, Maxzide, Dyazide

Why is Maxzide prescribed?

Dyazide is a combination of diuretic drugs used in the treatment of high blood pressure and other conditions that require the elimination of excess fluid from the body. When used for high blood pressure, Dyazide can be taken alone or with other high blood pressure medications. Diuretics help your body produce and eliminate more urine, which helps lower blood pressure. Triamterene, one of the ingredients of Dyazide, helps to minimize the potassium loss that can be caused by the other component, hydrochlorothiazide. Maxzide and Maxzide-25 MG contain the same combination of ingredients.

Most important fact about Maxzide

If you have high blood pressure, you must take Dyazide regularly for it to be effective. Since blood pressure declines gradually, it may be several weeks before you get the full benefit of Dyazide; and you must continue taking it even if you are feeling well. Dyazide does not cure high blood pressure; it merely keeps it under control.

How should you take Maxzide?

Dyazide should be taken early in the day. To avoid stomach upset, take it with food.

--If you miss a dose...

Take it as soon as you remember. If it is almost time for the next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at the same time.

--Storage instructions...

Store at room temperature, away from light.

What side effects may occur?

Side effects cannot be anticipated. If any occur or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Dyazide.

  • More common side effects may include:
    Abdominal pain, anemia, breathing difficulty, change in potassium level (causing symptoms such as numbness, tingling, muscle weakness, slow heart rate, shock), constipation, diabetes, diarrhea, dizziness, dizziness when standing up, dry mouth, fatigue, headache, hives, impotence, irregular heartbeat, kidney stones, muscle cramps, nausea, rash, sensitivity to light, strong allergic reaction (localized hives, itching, and swelling or, in severe cases shock), vomiting, weakness, yellow eyes and skin

Why should Maxzide not be prescribed?

If you are unable to urinate or have any serious kidney disease, if you have high potassium levels in your blood, or if you are taking other drugs that prevent loss of potassium, you should not take Dyazide.

If you are sensitive to or have ever had an allergic reaction to triamterene (Dyrenium), hydrochlorothiazide (Oretic), or sulfa drugs such as Gantrisin you should not take Maxzide.

Special warnings about Maxzide

When taking Dyazide, do not use potassium-containing salt substitutes. Take potassium supplements only if specifically directed to by your doctor. Your potassium level should be checked frequently.

If you are taking Dyazide and have kidney disease, your doctor should monitor your kidney function closely.

If you have liver disease, cirrhosis of the liver, heart failure, or kidney stones, Maxzide should be used with care. Diabetics may find that the drug increases their blood sugar levels, altering their insulin requirements.

Possible food and drug interactions when taking Maxzide

Dyazide should be used with caution if you are taking a type of blood pressure medication called an ACE inhibitor, such as Vasotec or Capoten.

If Dyazide is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Dyazide with the following:

Blood-thinning medications such as Coumadin
Corticosteroids such as Deltasone
Drugs for diabetes such as Micronase
Gout medications such as Zyloprim
Lithium (Lithonate)
Methenamine (Urised)
Nonsteroidal anti-inflammatory drugs such as Indocin and Dolobid
Other drugs that minimize potassium loss or contain potassium
Other high blood pressure medications such as Minipress
Salt substitutes containing potassium
Sodium polystyrene sulfonate (Kayexalate)

Special information if you are pregnant or breastfeeding

The effects of Dyazide during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Dyazide appears in breast milk and could affect a nursing infant. If Maxzide is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.

Recommended dosage


The usual dose of Dyazide is 1 or 2 capsules once daily, with appropriate monitoring of blood potassium levels by your doctor. The usual dose of Maxzide is 1 tablet daily. The recommendation for Maxzide-25 MG is 1 or 2 tablets daily taken in a single dose.


Safety and effectiveness in children have not been established.


Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical treatment immediately.

  • Symptoms of Dyazide overdose may include:
    Fever, flushed face, nausea, production of large amounts of pale urine, vomiting, weakness, weariness

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