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All about: Mephobarbital

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Generic Name: Mephobarbital (me-foe-BAR-bih-tal)
Brand Name: Mebaral

Mephobarbital is used for:

Treating anxiety, tension, and apprehension, and preventing seizures. It may also be used for other conditions as determined by your doctor.

Mephobarbital is a barbiturate. It works by depressing the central nervous system or brain. In low doses, it causes mild sedation. As the dose increases, it can cause sleep and even coma. As it causes the brain to relax, it also decreases seizure activity.

Do NOT use Mephobarbital if:

  • you are allergic to any ingredient in Mephobarbital
  • you have the blood disorder porphyria
  • you are taking sodium oxybate (GHB) or voriconazole

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mephobarbital :

Some medical conditions may interact with Mephobarbital . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have depression, pain, lung or breathing problems, heart problems, or myasthenia gravis
  • if you have a history of kidney or liver problems, substance abuse or dependence, or suicidal thoughts or behavior

Some MEDICINES MAY INTERACT with Mephobarbital . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Hydantoins (eg, phenytoin), monoamine oxidase (MAO) inhibitors (eg, phenelzine), quinine, sodium oxybate (GHB), stiripentol, or valproic acid because side effects, such as increased sedation and difficulty breathing, may occur
  • Anticoagulants (eg, warfarin), beta-blockers (eg, propranolol), clozapine, corticosteroids (eg, hydrocortisone), cyclosporine, doxorubicin, doxycycline, estrogens (eg, estradiol), griseofulvin, imatinib, metronidazole, oral contraceptives (eg, birth control pills), quinidine, theophylline, or voriconazolebecause the effectiveness of these medicines may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mephobarbital may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mephobarbital :

Use Mephobarbital as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Mephobarbital may be taken with or without food.
  • Take Mephobarbital regularly to receive the most benefit from it.
  • Taking Mephobarbital at the same time each day will help you remember to take it.
  • If you miss a dose of Mephobarbital , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Mephobarbital .

Important safety information:

  • Mephobarbital may cause dizziness, drowsiness, or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Mephobarbital . Using Mephobarbital alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Mephobarbital . Mephobarbital will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Mephobarbital may decrease the effectiveness of your birth control pills. To prevent pregnancy, use an additional form of birth control while you are using Mephobarbital and for a month after stopping Mephobarbital .
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Mephobarbital .
  • LAB TESTS, including blood cell counts and kidney and liver function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Mephobarbital with caution in the ELDERLY because they may be more sensitive to its effects.
  • Caution is advised when using Mephobarbital in CHILDREN because they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: Mephobarbital has been shown to cause harm to the human fetus. If you become pregnant, discuss with your doctor the benefits and risks of using Mephobarbital during pregnancy. Mephobarbital is excreted in breast milk. If you are or will be breast-feeding while you are using Mephobarbital , check with your doctor to discuss the risks to your baby.

Mephobarbital may be habit-forming and lead to DEPENDENCE if used in high doses or for a long period of time. If you are on long-term or high dosage therapy, you may have WITHDRAWAL symptoms (eg, anxiety, nausea, sleeplessness, body aches) if you suddenly stop taking Mephobarbital . Do not stop taking Mephobarbital suddenly or change the dose without asking your pharmacist or doctor. Also, when Mephobarbital is used in high doses or for a long period of time, it may not work as well and may require higher doses to have the same effect. This is known as TOLERANCE. Talk with your doctor if Mephobarbital stops working as well. Do not take more than prescribed. Discuss overuse with your doctor or pharmacist.

Possible side effects of Mephobarbital :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Clumsiness; dizziness; drowsiness; excessive daytime drowsiness ("hangover effect"); feeling of a whirling motion; headache; lightheadedness; nausea; tired feeling; vomiting; weak bones.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); confusion; difficulty sleeping; fainting; very slow breathing.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include change in size of pupil; cold, clammy skin; deep sleep; loss of consciousness; slowed or fast breathing.

Proper storage of Mephobarbital :

Store Mephobarbital at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Mephobarbital out of the reach of children and away from pets.

General information:

  • If you have any questions about Mephobarbital , please talk with your doctor, pharmacist, or other health care provider.
  • Mephobarbital is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Mephobarbital . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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