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All about: Mesna

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Generic Name: Mesna Injection (MES-na)
Brand Name: Mesnex

Mesna is used for:

Preventing or reducing the harmful effects of chemotherapy on the bladder.

Mesna is an uroprotectant. It works by protecting the bladder wall from the harmful effects of chemotherapy.

Do NOT use Mesna if:

  • you are allergic to any ingredient in Mesna or other thiol compounds

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mesna :

Some medical conditions may interact with Mesna . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an autoimmune disorder (eg, rheumatoid arthritis, lupus) or kidney problems (eg, nephritis)

Some MEDICINES MAY INTERACT with Mesna .

However, no specific interactions with Mesna are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mesna may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mesna :

Use Mesna as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Mesna is usually administered as an injection at your doctor's office, hospital, or clinic.
  • Drink at least 1 quart (4 cups/1 L) of liquid per day.
  • If you miss a dose of Mesna , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Mesna .

Important safety information:

  • Mesna may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Mesna . Using Mesna alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Tell your doctor if your urine turns a pink or red color or if you vomit within 2 hours of taking the oral form of Mesna .
  • Certain prescription medicines and foods, such as red beets, may also cause your urine to change colors. A lab test of your urine will show if the source of the color is due to one of these causes.
  • Diabetes patients - Mesna may cause incorrect test results with some urine glucose tests. Check with your doctor before you adjust your dose of your diabetes medicine or change your diet.
  • LAB TESTS, including urine tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Mesna with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • Mesna should not be used in INFANTS because it contains benzyl alcohol, which may cause serious reactions.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Mesna , discuss with your doctor the benefits and risks of using Mesna during pregnancy. It is unknown if Mesna is excreted in breast milk. Do not breast-feed while taking Mesna .

Possible side effects of Mesna :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bad taste in mouth; cold symptoms (coughing, sore throat); constipation; diarrhea; dizziness; drowsiness; fever; fluid retention; flushing; headache; loss of appetite; injection site reaction; nausea; pain in arms or legs; paleness; stomach pain; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty swallowing or breathing; tightness in the chest; swelling of the mouth, face, lips, hands, eyes, face, throat, or tongue); blood in the urine (pink or red urine); chest pain; difficulty swallowing; fast heartbeat; hoarseness.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately.

Proper storage of Mesna :

Mesna is usually handled and stored by a health care provider. If you are using Mesna at home, store Mesna as directed by your pharmacist or health care provider. Keep Mesna out of the reach of children and away from pets.

General information:

  • If you have any questions about Mesna , please talk with your doctor, pharmacist, or other health care provider.
  • Mesna is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Mesna . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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