17 . June , 2019 - Monday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Methoxsalen Extracorporeal-Systemic

Big Image

Some commonly used brand names are:

In the U.S.—

  • Uvadex

Category

  • Antineoplastic

Description

Methoxsalen (meth-OX-a-len)belongs to the group of medicines called psoralens. It is used along with ultraviolet light (found in sunlight and some special lamps) to treat the white blood cells from your blood in a process called photopheresis. The treated white blood cells are returned to your body to control skin problems associated with cutaneous T-cell lymphoma, a cancer of the lymph system.

Methoxsalen is to be administered only by or under the supervision of your doctor or other health care professional. It is available in the following dosage form:

  • Extracorporeal
  • Sterile solution (U.S.)

Before Using This Medicine

Methoxsalen is a very strong medicine that increases the skin's sensitivity to sunlight. In addition to causing serious sunburns, if precautions are not properly taken, it has been reported to increase the chance of skin cancer and cataracts. Too much sunlight can also cause premature aging of the skin. In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor wil make. For methoxsalen, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to psoralens. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—It is best to avoid pregnancy during treatment with this medicine. Studies in animals have found that methoxsalen causes birth defects and death of the fetus. Be sure you have discussed this with your doctor before starting treatments with this medicine. Also, tell your doctor right away if you think you have become pregnant while receiving this medicine.

Breast-feeding—It is not known whether methoxsalen passes into breast milk. Mothers who are receiving this medicine and who wish to breast-feed should discuss this with their doctor.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of methoxsalen in children with use in other age groups.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of methoxsalen in the elderly with use in other age groups.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your medical doctor may want to change the dose, or other precautions may be necessary. When you are receiving methoxsalen, it is especially important that your health care professional know if you are taking any of the following:

  • Anthralin (e.g., Drithocreme) or
  • Bacteriostatic soaps or
  • Certain organic dyes (such as methylene blue, methyl orange, rose bengal, and toluidine blue) or
  • Coal tar or medicine made from coal tar (e.g., Alphosyl) or
  • Griseofulvin (e.g., Fulvicin-U/F) or
  • Nalidixic acid (e.g., NegGram) or
  • Phenothiazines (acetophenazine [e.g., Tindel], chlorpromazine [e.g., Thorazine], fluphenazine [e.g., Prolixin], mesoridazine [e.g., Serentil], methotrimeprazine [e.g., Nozinan], pericyazine [e.g., Neuleptil], perphenazine [e.g., Trilafon], pipotiazine [e.g., Piportil L4 ], prochlorperazine [e.g., Compazine], promazine [e.g., Primazine], thiopropazate [e.g., Dartal], thioproperazine [e.g., Majeptil], thioridazine [e.g., Mellaril], trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin]) or
  • Sulfonamides (sulfa medicine) or
  • Tetracyclines (medicine for infection) or
  • Thiazide diuretics (water pills)—May increase sensitivity to light

Other medical problems—The presence of other medical problems may affect the use of methoxsalen. Make sure you tell your doctor if you have any other medical problems, especially:

  • Albinism (pigment lacking in the skin, hair, and eyes, or eyes only) or
  • Erythropoietic protoporphyria or
  • Lupus erythematosus or
  • Porphyria cutanea tarda or
  • Skin cancer or
  • Variegate porphyria or
  • Xeroderma pigmentosum—Methoxsalen treatment may make condition worse
  • Eye problems, such as cataracts or loss of the lens of the eye—Methoxsalen and light treatment may make these conditions worse or may cause damage to the eye

Precautions While Using This Medicine

Eating certain foods while you are receiving methoxsalen treatment may increase your skin's sensitivity to sunlight. To help prevent this, avoid eating limes, figs, parsley, parsnips, mustard, carrots, and celery while you are being treated with this medicine.

Your doctor should check your progress at regular visits to make sure this treatment is working and that it does not cause unwanted effects. You also should have regular eye examinations.

This medicine increases the sensitivity of your skin to sunlight and also may cause premature aging of the skin. Therefore, exposure to the sun, even through window glass or on a cloudy day, could cause a serious burn . If you must go out during the daylight hours:

  • After each treatment, cover your skin with protective clothing for at least 24 hours . In addition, use a sun block product that has a skin protection factor (SPF) of at least 15 on those areas of your body that cannot be covered. If you have any questions about this, check with your health care professional.
For 24 hours after your methoxsalen treatment, your eyes should be protected during daylight hours with special wraparound sunglasses that totally block or absorb ultraviolet light (ordinary sunglasses are not adequate). This is to prevent cataracts. Your doctor will tell you what kind of sunglasses to use. These glasses should be worn even in indirect light, such as light coming through a window, or on a cloudy day.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Rare

Fever; irregular heartbeat; redness or pain at catheter site

Symptoms of overdose

Blistering and peeling of skin; reddened, sore skin

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if the following side effect continues or is bothersome:

Reddening of skin, slight

Treatment with this medicine usually causes a slight reddening of your skin 24 to 48 hours after the treatment. This is an expected effect and is no cause for concern. However, check with your doctor right away if your skin becomes sore and red or blistered.

There is an increased risk of developing skin cancer after use of methoxsalen. You should check your body regularly and show your doctor any skin sores that do not heal, new skin growths, or skin growths that have changed in the way they look or feel.

Premature aging of the skin may occur as a result of prolonged methoxsalen therapy. This effect is permanent and is similar to what happens when a person sunbathes for long periods of time.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Developed: 09/17/1999

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

Recent Drug Updates at DrugIndexOnline:





Antivenin, Pit Viper Antivenin, Pit Viper
Some commonly used names are: antivenin (crotalidae) polyvalent and antvenin crotalid serum . Available as a generic name product in the U.S. and Canada. Category Immunizing agent, passive Description Pit viper antivenin belongs to a group of medicines known as immunizing agents. It is u more...

Disulfiram Disulfiram
Pronouncation: (die-SULL-fih-ram) Class: Antialcoholic agent Trade Names: Antabuse - Tablets 250 mg Mechanism of Action Pharmacology Produces intolerance to alcohol by blocking oxidation of acetaldehyde by enzyme aldehyde dehydrogenase, resulting in high blood levels of acetaldehyde and unpleasant more...

Fuzeon Fuzeon
Some commonly used brand names are: In the U.S.— Fuzeon Another commonly used name is T-20. † Not commercially available in Canada. Category Antiviral Description Enfuvirtide (en-FYOO-vir-tide) is used, in combination with other medicines, in the treatment of the infection more...

Kenalog in Orabase Kenalog in Orabase
Generic Name: triamcinolone topical (trye am SIH no lone) Brand Names: Aristocort Topical, Kenalog, Kenalog in Orabase, Triacet What is Kenalog in Orabase (triamcinolone topical)? Triamcinolone is a topical steroid. It reduces the actions of chemicals in the body that cause inflammation more...

Lotensin Lotensin
Generic name: Benazepril hydrochloride Brand names: Lotensin Why is Lotensin prescribed? Lotensin is used in the treatment of high blood pressure in adults and children 7 to 17 years old. It is effective when used alone or in combination with thiazide diuretics. Lotensin is in a family of drugs more...

Lovaza Lovaza
Generic Name: Omega-3-Acid Ethyl Esters Capsules (oh-MAY-ga 3 AS-id ETH-il ES-ters) Brand Name: LovazaLovaza is used for:Treating patients who have very high triglyceride levels. It is used in addition to a low fat diet. Lovaza is lipid-regulating medicine. Exactly how Lovaza works is not kno more...

Metaproterenol sulfate Metaproterenol sulfate
Generic name: Metaproterenol sulfate Brand names: Alupent Why is Metaproterenol sulfate prescribed? Alupent is a bronchodilator prescribed for the prevention and relief of bronchial asthma and bronchial spasms (wheezing) associated with bronchitis and emphysema. Alupent Inhalation Solution is al more...

Novo-Miconazole Vaginal Ovules Vaginal Novo-Miconazole Vaginal Ovules Vaginal
Some commonly used brand names are: In the U.S.— FemCare 2 Femizol-M 4 Femstat 3 1 Gyne-Lotrimin 2 Gyne-Lotrimin Combination Pack 2 Gyne-Lotrimin3 2 Gyne-Lotrimin3 Combination Pack 2 Miconazole-7 4 Monistat 1 6 Monistat 1 Combination Pack 4 Monistat 3 4 Monistat 3 Combination Pack 4 Monis more...