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All about: Methylprednisolone Suspension

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Generic Name: Methylprednisolone Injection Suspension (meth-il-pred-NIS-oh-lone)
Brand Name: Depo-Medrol

Methylprednisolone Suspension is used for:

Treating certain conditions associated with decreased adrenal gland function. It is also used to treat severe inflammation due to certain conditions, including severe asthma, severe allergies, rheumatoid arthritis, ulcerative colitis, certain blood disorders, lupus, multiple sclerosis, and certain eye and skin conditions. It may also be used for other conditions as determined by your doctor.

Methylprednisolone Suspension is a corticosteroid. It works by modifying the body's immune response and decreasing inflammation.

Do NOT use Methylprednisolone Suspension if:

  • you are allergic to any ingredient in Methylprednisolone Suspension
  • you are taking mifepristone
  • you have a systemic fungal infection
  • you are scheduled to have a smallpox vaccine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Methylprednisolone Suspension:

Some medical conditions may interact with Methylprednisolone Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of bleeding problems, heart problems (eg, congestive heart failure), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, or any mental or mood problems
  • if you have recently had a fungal, bacterial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; or shingles
  • if you have HIV infection or tuberculosis (TB), or if you have ever had a positive TB skin test
  • if you have stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, infection, unexplained diarrhea, diverticulitis, ulcerative colitis), or inflammation of the esophagus, or you have had recent intestinal surgery
  • if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)
  • if you have had any recent vaccinations (eg, smallpox)

Some MEDICINES MAY INTERACT with Methylprednisolone Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), lithium, or rifampin because they may decrease Methylprednisolone Suspension's effectiveness
  • Aprepitant, clarithromycin, cyclosporine, diltiazem, erythromycin, itraconazole, ketoconazole, or troleandomycin because side effects, such as adrenal gland or nervous system problems (eg, seizures), may occur
  • Aspirin, mifepristone, ritodrine, or live vaccines because the risk of their side effects may be increased by Methylprednisolone Suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if Methylprednisolone Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Methylprednisolone Suspension:

Use Methylprednisolone Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Methylprednisolone Suspension is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Methylprednisolone Suspension at home, a health care provider will teach you how to use it. Be sure you understand how to use Methylprednisolone Suspension. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Methylprednisolone Suspension if it contains particles, or is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you miss a dose of Methylprednisolone Suspension, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Methylprednisolone Suspension.

Important safety information:

  • Methylprednisolone Suspension may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.
  • Tell your doctor or dentist that you take Methylprednisolone Suspension before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Methylprednisolone Suspension may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Talk with your doctor before you receive any vaccine while you are using Methylprednisolone Suspension.
  • Lab tests, including adrenal function tests and blood pressure monitoring, may be performed while you use Methylprednisolone Suspension. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Methylprednisolone Suspension contains benzyl alcohol, which has been associated with serious and sometimes fatal breathing problems, in premature infants. Do NOT use Methylprednisolone Suspension in premature infants.
  • Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Methylprednisolone Suspension.
  • Methylprednisolone Suspension should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Methylprednisolone Suspension while you are pregnant. It is not known if Methylprednisolone Suspension is found in breast milk. If you are or will be breast-feeding while you use Methylprednisolone Suspension, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Methylprednisolone Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Acne; clumsiness; dizziness; facial flushing; feeling of whirling motion; general body discomfort; headache; increased appetite; increased sweating; nausea; nervousness; pain, swelling, or redness at the injection site; sleeplessness; upset stomach.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual periods; changes in skin color; chest pain; easy bruising or bleeding; mental or mood changes (eg, depression); muscle pain, weakness, or wasting; swelling of feet or legs; seizures; severe nausea or vomiting; sudden severe dizziness or headache; symptoms of infection (eg, fever, chills, sore throat); tendon or bone pain; thinning of the skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include dizziness; fainting; fever; loss of appetite; low blood pressure; low blood sugar; muscle pain; nausea.

Proper storage of Methylprednisolone Suspension:

Methylprednisolone Suspension is usually handled and stored by a health care provider. If you are using Methylprednisolone Suspension at home, store Methylprednisolone Suspension as directed by your pharmacist or health care provider. Keep Methylprednisolone Suspension out of the reach of children and away from pets.

General information:

  • If you have any questions about Methylprednisolone Suspension, please talk with your doctor, pharmacist, or other health care provider.
  • Methylprednisolone Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Methylprednisolone Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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