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All about: Metolazone

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Generic Name: Metolazone (meh-TOLE-uh-ZONE)
Brand Name: Zaroxolyn

Metolazone is used for:

Treating high blood pressure. It may be used with other high blood pressure medicines. It may also be used for other conditions as determined by your doctor.

Metolazone is a quinazoline diuretic with actions similar to thiazide type diuretics (eg, hydrochlorothiazide). It works by causing the kidneys to eliminate certain chemicals, which in turn allow large amounts of water to be eliminated.

Do NOT use Metolazone if:

  • you are allergic to any ingredient in Metolazone
  • you are unable to urinate
  • you have precoma or are in a coma caused by severe liver disease

Contact your doctor or health care provider right away if any of these apply to you.

Before using Metolazone :

Some medical conditions may interact with Metolazone . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have lupus, kidney or liver disease, low blood sodium or potassium levels, or gout

Some MEDICINES MAY INTERACT with Metolazone . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Nonsteroidal antiinflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen) because they may decrease Metolazone 's effectiveness
  • Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), diazoxide, ketanserin, loop diuretics (eg, furosemide), NSAIDs (eg, ibuprofen, naproxen) because side effects, such as kidney problems, may occur
  • ACE inhibitors (eg, enalapril), allopurinol, amantadine, antineoplastic agents (eg, cyclophosphamide), diazoxide, digitalis glycosides (eg, digoxin), ketanserin, lithium, loop diuretics (eg, furosemide), or nondepolarizing muscle relaxants (eg, vecuronium) because the risk of their side effects may be increased by Metolazone

This may not be a complete list of all interactions that may occur. Ask your health care provider if Metolazone may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Metolazone :

Use Metolazone as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Metolazone by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Metolazone may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of Metolazone , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Metolazone .

Important safety information:

  • Metolazone may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Metolazone with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Metolazone may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Metolazone may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Metolazone . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Do not change brands of Metolazone without talking to your doctor. Products made by other companies may not work as well for you.
  • Check with your doctor before you use a salt substitute or a product that has potassium in it.
  • Lab tests, including liver function, kidney function, and complete blood cell counts, may be performed while you use Metolazone . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Metolazone should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Metolazone while you are pregnant. Metolazone is found in breast milk. Do not breast-feed while taking Metolazone .

Possible side effects of Metolazone :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensations; constipation; diarrhea; dizziness; feeling of a whirling motion; headache; impotence; joint pain; lightheadedness; loss of appetite; nausea; purple patches under the skin; skin sensitivity to sunlight; stomach bloating; stomach pain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain/discomfort; depression; drowsiness; dry mouth; fainting; gout attacks; lightheadedness when rising from a seated position; muscle pain or cramps; rapid or irregular heartbeat; restlessness; unusual thirst; unusual tiredness or weakness; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1- 800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include dizziness; drowsiness; dry mouth; excessive urination followed by a decrease in amount of urine; fainting; irregular or weak heartbeat; lightheadedness when rising from a seated position; muscle cramps.

Proper storage of Metolazone :

Store Metolazone at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Metolazone out of the reach of children and away from pets.

General information:

  • If you have any questions about Metolazone , please talk with your doctor, pharmacist, or other health care provider.
  • Metolazone is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Metolazone . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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