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All about: Micafungin

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Some commonly used brand names are:

In the U.S.—

  • Mycamine

Not commercially available in Canada.

Category

  • Antifungal, systemic

Description

Micafungin (me-ka-FUN-jin) is an antifungal. It is used to help the body overcome serious fungus infections.

This medicine is available only with your doctor's prescription, in the following dosage forms:

  • Parenteral
  • Injection (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For micafungin, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to micafungin. Also tell your doctor and pharmacist if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Micafungin has not been studied in pregnant women. However, studies in animals have shown that micafungin causes birth defects or other problems. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—It is not known whether micafungin passes into breast milk. Although most medicines pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children—Studies on this medicine have been done only in adult patients, and there is no specific information comparing the use of micafungin in children with use in other age groups.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing use of micafungin in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking micafungin, it is especially important that your doctor and pharmacist know if you are taking any of the following:

  • Nifedipine (e.g., Adalat, Procardia) or
  • Sirolimus (e.g., Rapamune)—Use of micafungin may increase the amount of these medicines in the body; it may be necessary for your doctor to reduce your dose of nifedipine or sirolimus

Other medical problems—The presence of other medical problems may affect the use of micafungin. Make sure you tell your doctor if you have any other medical problems, especially:

  • Liver disease, moderate to severe—Higher blood levels of micafungin may result, increasing the chance of side effects

Proper Use of This Medicine

Dosing—The dose of micafungin will be different for different patients. The following information includes only the average doses of micafungin.

  • For injection dosage form:
    • Candidiasis, esophageal
      • Adults—Intravenous (into the vein), 150 milligrams daily for approximately 15 days (range 10 to 30 days).
      • Children—Use and dose must be determined by your doctor.
  • For injection dosage form:
    • For the prevention of Candida
      • Adults—Intravenous (into the vein), 50 milligrams daily for approximately 19 days (range 6 to 51 days).
      • Children—Use and dose must be determined by your doctor.

Missed dose—If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Bone pain; chest pain; chills; convulsions; cough; decreased urine; drowsiness; dry mouth; fever; hoarseness; increased thirst; irregular heartbeat; lab results that show problems with liver; loss of appetite; lower back or side pain; mood or mental changes; muscle pain or cramps; muscle spasms or twitching; nausea; numbness or tingling in hands, feet, or lips; painful or difficult urination; seizures; shortness of breath; sore throat; sores, ulcers, or white spots on lips or in mouth; swollen glands; trembling; trouble breathing; ulcers, sores, or white spots in mouth; vomiting

Rare

Abdominal cramps; black, tarry stools; bleeding gums; blood in urine or stools; blurred vision; confusion; dizziness; headache; nervousness; pale skin; pinpoint red spots on skin; pounding in the ears; slow or fast heartbeat; tremor; troubled breathing with exertion; unusual bleeding or bruising; unusual tiredness or weakness

Frequency unknown

Cold clammy skin; difficulty swallowing; fast, weak pulse; hives; itching; lightheadedness; puffiness or swelling of the eyelids or around the eyes, face, lips or tongue; skin rash; rash, or redness; sweating; swelling of face, throat, or tongue; tightness in chest; wheezing

Observed during postmarketing trials

Agitation; back, leg, or stomach pains; bleeding gums; coma; dark urine; depression; diarrhea; general body swelling; hostility; increased blood pressure; increased thirst; irritability; lethargy; light-colored stools; muscle twitching; nosebleeds; rapid weight gain; seizures; stomach pain; swelling of face, ankles, or hands; swelling of lower legs; stupor; troubled breathing; unpleasant breath odor; vomiting of blood; white blood cell count decreased; yellow eyes or skin

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

Less common

Bluish color; changes in skin color; feeling unusually cold; shivering; infusion site inflammation; pain; stomach pain; swelling of foot or leg; tenderness

Rare

Acid or sour stomach; belching; change in taste; confusion as to time, place, or person; difficulty having a bowel movement (stool); feeling of warmth; hallucinations; heartburn; hiccups; holding false beliefs that cannot be changed by fact; indigestion; injection site pain; loss of taste; redness of the face, neck, arms and occasionally upper chest; sleepiness or unusual drowsiness; stomach discomfort upset or pain; unusual excitement, nervousness, or restlessness; upper stomach pain

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Developed: 04/14/2005

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