14 . November , 2018 - Wednesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Mifeprex

Big Image

Some commonly used brand names are:

In the U.S.—

  • Mifeprex

Other commonly used names are

RU 486


  • Abortifacient


Mifepristone (mif-i-PRIS-tone)is used to end a pregnancy that is less than 49 days in duration. It works by stopping the supply of hormones that maintains the interior of the uterus. Without these hormones, the uterus cannot support the pregnancy and the contents of the uterus are expelled.

This medicine is available only with your doctor's prescription, in the following dosage form:

  • Oral
  • Tablets (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For mifepristone, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to mifepristone, misoprostol or any other prostaglandins.

Pregnancy—Mifepristone is used to terminate an early pregnancy. Fetal deformities may result if a pregnancy is allowed to continue following a failed attempt at medical termination.

Breast-feeding—It is unknown whether mifepristone is distributed in the breast milk. It may be necessary for you to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of this treatment with your doctor.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking mifepristone, it is especially important that your doctor and pharmacist know if you are taking any of the following:

  • Carbamazepine (e.g., Tegretol) or
  • Dexamethasone (e.g., Decadron) or
  • Phenobarbital (e.g., Luminal) or
  • Phenytoin (e.g., Dilantin) or
  • Rifampin (e.g., Rifadin) or
  • St. John's Wort — May decrease the concentration of mifepristone in the blood
  • Erythromycin (e.g., E-Mycin) or
  • Grapefruit juice or
  • Itraconazole (e.g., Sporanox) or
  • Ketoconazole (e.g., Nizoral) — May increase the concentration of mifepristone in the blood
  • Anticoagulants, such as warfarin (e.g., Coumadin) — May increase the risk of bleeding
  • Corticosteroids (cortisone-like medicine)—Mifepristone may not work as well

Other medical problems—The presence of other medical problems may affect the use of mifepristone. Make sure you tell your doctor if you have any other medical problems, especially:

  • Adrenal failure—Mifepristone may not work appropriately
  • Bleeding problems—May cause excessive vaginal bleeding
  • Diabetes or
  • Heart disease or
  • High blood pressure or
  • Kidney disease or
  • Liver disease or
  • Lung disease
  • Women older than 35 years of age who smoke cigarettes (10 or more a day)—You should use caution if you have any of these chronic conditions and let your doctor know before beginning treatment with this medicine.
  • Ectopic pregnancy (e.g., a pregnancy that develops in fallopian tubes instead of the uterus) or
  • Lower abdominal mass—Mifepristone will not terminate an ectopic pregnancy
  • An intrauterine device (IUD) that is still in the uterus—Must be removed before mifepristone therapy is started
  • Porphyria, inherited
  • Anemia, severe or
  • Poor blood circulation or
  • Inability of blood to clot properly—Mifepristone causes heavy bleeding in a small portion of users, this may be intensified in patients with bleeding disorders

Proper Use of This Medicine


  • To terminate a pregnancy of 49 days or less duration:
    • For oral dosage form (tablets):
      • Adults—600 milligrams (mg) (three 200 mg tablets) as a single oral dose followed two days later by 400 micrograms (mcg) (two 200 mcg tablets) of misoprostol as a single oral dose as needed.

Precautions While Using This Medicine

You must have 3 visits to your physicians office during the treatment procedure. It is extremely important that you attend all three visits.

Check with your physician if the vaginal bleeding becomes severe or seems to last longer than expected (i.e., soaking through two thick full-size sanitary pads per hour for two consecutive hours) .

You may need to have a surgical procedure to stop excessive vaginal bleeding or to terminate a pregnancy that was not terminated with the medical treatment procedure.

You should check with your physician immediately if signs or symptoms of serious infection (i.e., continuing fever [ge ] 100.4 °F, severe stomach pain, pelvic tenderness, weakness, nausea, vomiting, diarrhea, or abnormally fast heartbeat) occur.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

Excessively heavy vaginal bleeding; unusual tiredness or weakness

Incidence not known

Chest pain or discomfort; confusion; cough or hoarseness; fast, weak pulse; fever or chills; lower back or side pain; pain or discomfort in arms, jaw, back or neck; painful or difficult urination; pale, cold, clammy skin; shortness of breath; sudden increase in abdominal or shoulder pain; sweating; unusual or large amount of vaginal bleeding

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

More common

Abdominal pain or uterine cramping; back pain; diarrhea; dizziness; headache; nausea or vomiting

Less common

Acid or sour stomach; anxiety; belching ; cough; fainting or light-headedness when getting up from a lying or sitting position ; fever ; flu-like symptoms; headache; heartburn ; increased clear or white vaginal discharge; indigestion ; itching of the vagina or genital area; lack or loss of strength; pain during sexual intercourse; pain or tenderness around eyes and cheekbones; pale skin; shaking chills; shortness of breath or troubled breathing; sleeplessness or trouble sleeping ; stomach discomfort, upset, or pain; tightness of chest or wheezing; troubled breathing, exertional; unusual bleeding or bruising; stuffy or runny nose

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Developed: 10/13/2000
Revised: 09/14/2005

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

Recent Drug Updates at DrugIndexOnline:

Albuterol Oral/Injection Albuterol Oral/Injection
Some commonly used brand names are: In the U.S.— Adrenalin 3 Alupent 5 Ana-Guard 3 Brethine 6 Bricanyl 6 EpiPen Auto-Injector 3 EpiPen Jr. Auto-Injector 3 Isuprel 4 Proventil 1 Proventil Repetabs 1 Ventolin 1 Volmax 1 In Canada— Adrenalin 3 Alupent 5 Bricanyl 6 EpiPen Auto-Injecto more...

captopril captopril
Generic Name: captopril (KAP toe pril) Brand Names: Capoten What is captopril? Captopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Captopril is used to treat high blood pressure (hypertension), congestive heart failure, kidney problems c more...

Coversyl Coversyl
Some commonly used brand names are: In the U.S.— Accupril 10 Aceon 9 Altace 11 Capoten 2 Lotensin 1 Mavik 12 Monopril 6 Prinivil 7 Univasc 8 Vasotec 4 5 Zestril 7 In Canada— Accupril 10 Altace 11 Capoten 2 Coversyl 9 Inhibace 3 Lotensin 1 Mavik 12 Monopril 6 Prinivil 7 Vasotec 4 5 more...

Galsulfase Galsulfase
Some commonly used brand names are: In the U.S.— Naglazyme † Not commercially available in Canada. Category Enzyme replenisher Description Galsulfase (gal-SUL-face ) is used to treat mucopolysaccharidosis (MPS VI) disease caused by the lack of a certain enzyme called N-ace more...

Humulin U Humulin U
Generic Name: insulin zinc extended (IN suh lin ZINK) Brand Names: Humulin U What is Humulin U (insulin zinc extended)? Insulin is a hormone naturally produced by the pancreas. Insulin enables the body to use the sugar in food as a source of energy. When the body does not produce enough more...

Metronidazole Cream Metronidazole Cream
Generic Name: Metronidazole Cream, Gel, and Lotion (me-troe-NIH-duh-zole) Brand Name: Examples include MetroCream, MetroGel, and MetroLotionMetronidazole Cream is used for:Treating redness and inflammation associated with the skin disorder rosacea. It also may be used for other conditions as d more...

phenylephrine phenylephrine
Generic Name: phenylephrine (fen ill EFF rin) Brand Names: Ah-Chew D, Lusonal, Nasop, Neo-Synephrine What is phenylephrine? Phenylephrine is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries). Constriction of blood vessels in the sinuses, nose, and ch more...

Phenylhistine DH Expectorant Phenylhistine DH Expectorant
Generic Name: chlorpheniramine, codeine, and pseudoephedrine (klor fen EERa meen, KOE deen, soo doe e FED rin) Brand Names: Codahistine-DH Elixir, Dihistine DH, Phenylhistine DH Expectorant What is Phenylhistine DH Expectorant (chlorpheniramine, codeine, and pseudoephedrine)? Chlorpheni more...