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All about: Minitran Patch

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Generic Name: Nitroglycerin Transdermal Patch (nye-troe-GLI-ser-in)
Brand Name: Examples include Minitran and Nitro-Dur

Minitran Patch is used for:

Preventing chest pain due to heart disease. It also may be used for certain conditions as determined by your doctor.

Minitran Patch is a nitrate vasodilator. It works by relaxing blood vessels in the body, which allows them to widen (dilate). This allows more blood to flow through the blood vessels easier, which reduces the workload on the heart.

Do NOT use Minitran Patch if:

  • you are allergic to any ingredient in Minitran Patch
  • you are allergic to the adhesive that makes the patch stick to your skin
  • you are currently taking a phosphodiesterase type 5 inhibitor (eg, sildenafil)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Minitran Patch:

Some medical conditions may interact with Minitran Patch. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bleeding in the brain or have had a recent head injury
  • if you have heart problems, severe anemia, an overactive thyroid, or low blood pressure

Some MEDICINES MAY INTERACT with Minitran Patch. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Calcium channel blockers (eg, verapamil) or phosphodiesterase type 5 inhibitors (eg, sildenafil) because side effects, such as low blood pressure, may occur
  • Alteplase because the effectiveness of Minitran Patch may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Minitran Patch may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Minitran Patch:

Use Minitran Patch as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Minitran Patch comes with an additional patient leaflet. Read it carefully and reread it each time you get Minitran Patch refilled.
  • Minitran Patch is for external use only.
  • Wash your hands thoroughly before and after applying.
  • Apply the patch to the chest, inner side of the upper arm, or shoulder.
  • Clean and dry the skin before applying the patch. If necessary, hair may be removed by clipping.
  • Remove the patch from the package. Apply with a firm pressure to the skin. To avoid skin irritation, change the treatment site daily. Do not apply to irritated or damaged skin.
  • If the patch becomes loose, remove it and apply a new patch at a different site.
  • After you remove the used patch, fold the sticky side together and throw away.
  • This patch should only be worn for up to 12 to 14 hours a day, or as directed by your doctor, so that you will have a 10 to 12 hour "nitrate-free" period each day. Do not use more of Minitran Patch than prescribed. It is important to have a "nitrate-free" period of time each day for Minitran Patch to continue to work well and to decrease the risk of physical dependence.
  • If you miss a dose of Minitran Patch, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Minitran Patch.

Important safety information:

  • Minitran Patch may cause dizziness or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Minitran Patch. Using Minitran Patch alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Minitran Patch may cause dizziness, lightheadedness, or fainting. Alcohol, hot weather, exercise, and fever can increase these effects. To prevent them, sit or stand up slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness, lightheadedness, or weakness.
  • Minitran Patch may give you daily headaches. This should become less noticeable with time.
  • Minitran Patch takes about 1 to 2 hours to start working and should not be used for a sudden chest pain attack.
  • Use Minitran Patch with caution in the ELDERLY because they may be more sensitive to its effects.
  • Minitran Patch is not recommended for use in CHILDREN; safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Minitran Patch during pregnancy. It is unknown if Minitran Patch is excreted in breast milk. Do not breast-feed while taking Minitran Patch.

When used for long periods of time without a break, Minitran Patch may not work as well. This is known as TOLERANCE. Tolerance to other nitrates and nitrites may also occur. Increasing the dose is not effective in managing tolerance to Minitran Patch. Talk with your doctor if Minitran Patch stops working well. Do not take more than prescribed.

When used for long periods of time without a break, some people develop a physical need to continue taking Minitran Patch. This is known as physical DEPENDENCE. Do not suddenly stop taking Minitran Patch without your doctor's approval. Stopping Minitran Patch suddenly may cause serious, possibly life-threatening, WITHDRAWAL symptoms, including chest pain and heart attack. Having a nitrate-free period each day will help prevent tolerance, dependence, and withdrawal problems.

Possible side effects of Minitran Patch:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness, lightheadedness, or fainting when sitting up or standing; fast heartbeat; flushing of face and neck; headache; irritation at site of patch; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fainting; increased chest pain.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include changes in heart rate; changes in vision; confusion; dizziness; flushing; nausea; persistent, throbbing headache; sweating; vomiting; weakness.

Proper storage of Minitran Patch:

Store this medicine at room temperature between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Minitran Patch out of the reach of children and away from pets.

General information:

  • If you have any questions about Minitran Patch, please talk with your doctor, pharmacist, or other health care provider.
  • Minitran Patch is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Minitran Patch. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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