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All about: Morphine Sustained-Release Tablets

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Generic Name: Morphine Sustained-Release Tablets (MORE-feen)
Brand Name: Examples include MS Contin and Oramorph SR

Morphine Sustained-Release Tablets is used for:

Managing moderate to severe pain for more than a few days.

Morphine Sustained-Release Tablets is a narcotic pain reliever. It works by dulling the pain perception center in the brain. It may also affect other body systems (eg, breathing and circulatory systems) at higher doses.

Do NOT use Morphine Sustained-Release Tablets if:

  • you are allergic to any ingredient in Morphine Sustained-Release Tablets
  • you have known or suspected paralysis of the intestines or antibiotic-associated colitis
  • you have diarrhea due to poisoning, slowed breathing, severe asthma, or are having an asthma attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using Morphine Sustained-Release Tablets:

Some medical conditions may interact with Morphine Sustained-Release Tablets. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of drug abuse or dependence, have asthma, chronic obstructive pulmonary disease (COPD), or other lung or breathing problems
  • if you have increased pressure in the head, recent head injury, or lesions in the head
  • if you have difficulty urinating; heart, liver, or thyroid disease; hypercapnia (abnormally increased carbon dioxide tension in your arteries); curvature of the spine; seizures; or a history of suicidal thoughts or behaviors
  • if you have low blood volume, a stomach blockage, inflammatory bowel disease, have had stomach tract surgery, or are in shock

Some MEDICINES MAY INTERACT with Morphine Sustained-Release Tablets. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Fluoxetine, naltrexone, narcotic agonists/antagonists (eg, pentazocine), rifampin, or risperidone because they may decrease Morphine Sustained-Release Tablets's effectiveness
  • Barbiturate anesthetics (eg, thiopental),cimetidine, ethanol, ketorolac, sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects such as CNS toxicity (disorientation, respiratory depression, seizures) may occur
  • Barbiturate anesthetics (eg, thiopental) or sodium oxybate (GHB) because the risk of their side effects may be increased by Morphine Sustained-Release Tablets
  • Mexiletine or trovafloxacin because their effectiveness may be decreased by Morphine Sustained-Release Tablets

This may not be a complete list of all interactions that may occur. Ask your health care provider if Morphine Sustained-Release Tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Morphine Sustained-Release Tablets:

Use Morphine Sustained-Release Tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Morphine Sustained-Release Tablets by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Swallow Morphine Sustained-Release Tablets whole. Do not break, crush, or chew before swallowing.
  • Take Morphine Sustained-Release Tablets on a regular schedule to get the most benefit from it. It is more effective in preventing pain than in treating pain after it occurs.
  • If you also take trovafloxacin, do not take it within 4 hours before or after taking Morphine Sustained-Release Tablets. Check with your doctor if you have questions.
  • If you miss a dose of Morphine Sustained-Release Tablets, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Morphine Sustained-Release Tablets.

Important safety information:

  • Morphine Sustained-Release Tablets may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Morphine Sustained-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Morphine Sustained-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Morphine Sustained-Release Tablets may cause constipation. Constipation may be avoided by using a stool softener or fiber laxative.
  • The risk of Morphine Sustained-Release Tablets becoming habit-forming may be greater if you take it in high doses or for a long time. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Tell your doctor or dentist that you take Morphine Sustained-Release Tablets before you receive any medical or dental care, emergency care, or surgery.
  • Do not take Morphine Sustained-Release Tablets if you have had a severe allergic reaction to morphine or hydromorphone (such as MS Contin, Roxanol, Dilaudid). If you have a question about whether you are allergic to Morphine Sustained-Release Tablets or if a certain medicine contains morphine or hydromorphone, contact your doctor or pharmacist.
  • Lab tests may be performed while you use Morphine Sustained-Release Tablets. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Morphine Sustained-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects.
  • Morphine Sustained-Release Tablets should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Morphine Sustained-Release Tablets while you are pregnant. Morphine Sustained-Release Tablets is found in breast milk. Do not breast-feed while taking Morphine Sustained-Release Tablets.

When used for long periods of time or at high doses, Morphine Sustained-Release Tablets may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Morphine Sustained-Release Tablets stops working well. Do not take more than prescribed.

Some people who use Morphine Sustained-Release Tablets for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction. If you stop taking Morphine Sustained-Release Tablets suddenly, you may have WITHDRAWAL symptoms. These may include anxiety; diarrhea; fever, runny nose, or sneezing; goose bumps and abnormal skin sensations; nausea; vomiting; pain; rigid muscles; rapid heartbeat; seeing, hearing or feeling things that are not there; shivering or tremors; sweating; and trouble sleeping.

Possible side effects of Morphine Sustained-Release Tablets:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; dizziness; drowsiness; exaggerated sense of well-being; headache; lightheadedness; nausea; restless mood; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); excessive drowsiness; fast or slow heartbeat; hallucinations; pounding in the chest; seizure; shock; shortness of breath; sudden chest pain; sweating; swelling of the face or throat.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include cold and clammy skin; convulsions; deep sleep; dizziness; drowsiness; lightheadedness; loss of consciousness; low body temperature; slowed breathing; slowed heartbeat.

Proper storage of Morphine Sustained-Release Tablets:

Store Morphine Sustained-Release Tablets between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, light, and moisture. Flush any unused medicine down the toilet. Do not store in the bathroom. Keep Morphine Sustained-Release Tablets out of the reach of children and away from pets.

General information:

  • If you have any questions about Morphine Sustained-Release Tablets, please talk with your doctor, pharmacist, or other health care provider.
  • Morphine Sustained-Release Tablets is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Morphine Sustained-Release Tablets. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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