23 . October , 2018 - Tuesday
Check todays hot topics or new products

Find a Drug: Advanced

Please Sign in or Register

All about: Mupirocin (Pseudomonic Acid A)

Big Image ( Pseudomonic Acid A ) Pronouncation: (myoo-PIHR-oh-sin)
Class: Antibiotic agent

Trade Names:
Bactroban
- Ointment 2%
- Cream 2%

Trade Names:
Bactroban Nasal
- Ointment 2%

Mechanism of Action

Pharmacology

Inhibits bacterial protein synthesis.

Pharmacokinetics

Absorption

Cream

Systemic absorption of mupirocin through human intact skin is minimal by detection of the metabolite, monic acid, in urine. More frequent occurrence of percutaneous absorption in children (90%) was found compared with adults (44%). Mupirocin is highly protein bound (more than 97%).

Ointment

Measurable systemic absorption.

Nasal

No evidence of systemic absorption.

Metabolism

Any mupirocin reaching the systemic circulation is rapidly metabolized, predominantly to inactive monic acid, which is eliminated by renal excretion. The elimination t ½ after IV administration was 20 to 40 min for mupirocin and 30 to 80 min for monic acid.

Indications and Usage

Treatment of impetigo caused by Staphylococcus aureus and Streptococcus pyogenes (topical ointment); treatment of secondarily infected traumatic skin lesions (up to 10 cm in length or 100 cm 2 in area) caused by susceptible strains of S. aureus and S. pyogenes (topical cream); eradication of nasal colonization with methicillin-resistant S. aureus in adult patients and health care workers (nasal).

Contraindications

Standard considerations.

Dosage and Administration

Adults and Children

Topical ointment Apply small amount to affected area tid. Reevaluate lesions not showing a response in 3 to 5 days. Topical cream Apply small amount to affected area tid for 10 days. Reevaluate lesions not showing a response in 3 to 5 days.

Adults and Children 12 yr and older

Nasal Divide approximately one-half of the ointment from a single-use tube between the nostrils and apply morning and evening for 5 days.

Storage/Stability

Store topical ointment at controlled room temperature (68° to 77°F). Store nasal ointment and topical cream below 77°F. Protect cream from freezing.

Drug Interactions

None well documented.

Laboratory Test Interactions

None well documented.

Adverse Reactions

CNS

Topical

Headache (2%).

Nasal

Headache (9%).

Dermatologic

Topical

Burning, stinging, pain, pruritus (2%); itching (1%); secondarily infected eczema.

Nasal

Burning, stinging (2%); pruritus (1%).

EENT

Nasal

Rhinitis (6%); pharyngitis (4%); taste perversion (3%); burning, stinging cough (2%).

GI

Topical

Nausea (5%) (secondary infected eczema).

Respiratory

Nasal

Respiratory disorder (5%); cough (2%).

Precautions

Pregnancy

Category B .

Lactation

Undetermined.

Children

Ointment and cream

Safety and efficacy have been established in children 2 mo to 16 yr (ointment) and in children 3 mo to 16 yr (cream).

Nasal

Safety and efficacy not established in children under 12 yr.

Hypersensitivity

Chemical irritation may occur.

Superinfection

Prolonged use of antibiotics may result in overgrowth of nonsusceptible organisms, including fungi.

Open wounds (ointment only)

Because polyethylene glycol can be absorbed from open wounds and damaged skin and is excreted by the kidneys, do not use if absorption of large quantities is possible, especially if evidence of moderate or severe renal impairment.

Prophylaxis

Insufficient data to recommend use of mupirocin nasal for general prophylaxis of any infection.

Patient Information

  • Warn the patient to avoid contact of drug with eyes and mucous membranes.
  • Instruct patient to wash hands before and after application.
  • Tell patient to inform health care provider if no improvement is seen within 3 to 5 days or if condition worsens.
  • Advise patient to keep fingernails well trimmed to prevent scratching.
  • Review with patient and family appropriate hygiene measures to prevent spread of impetigo.
  • Instruct patient to report the following symptoms to health care provider: burning, stinging, pain, nausea, tenderness, swelling, rash, dry skin, increased exudate.

Recent Drug Updates at DrugIndexOnline:





Cefizox Cefizox
Generic Name: ceftizoxime Dosage Form: For injection, usp To reduce the development of drug-resistant bacteria and maintain the effectiveness of Cefizox and other antibacterial drugs, Cefizox should be used only to treat or prevent infections that are proven or strongly suspected to be caused by more...

I-Phrine Ophthalmic I-Phrine Ophthalmic
Some commonly used brand names are: In the U.S.— Ak-Dilate Ak-Nefrin Dilatair I-Phrine Isopto Frin Mydfrin Neofrin Neo-Synephrine Ocugestrin Ocu-Phrin Sterile Eye Drops Ocu-Phrin Sterile Ophthalmic Solution Phenoptic Prefrin Liquifilm Relief Eye Drops for Red Eyes In Canada— Ak-Di more...

Lantus Vials Lantus Vials
Generic Name: Insulin Glargine Vials (IN-su-lin GLAR-jeen) Brand Name: LantusLantus Vials is used for:Treating diabetes mellitus. Lantus Vials is a long-acting form of the hormone insulin. It works by helping your body to use sugar properly. This lowers the amount of glucose in the blood, which more...

Metamucil Smooth Metamucil Smooth
Some commonly used brand names are: In the U.S.— Agoral 35 Alophen 25 Alphamul 30 Alramucil Orange 7 Alramucil Regular 7 Bisac-Evac 25 Black-Draught 26 Black-Draught Lax-Senna 32 Carter's Little Pills 25 Cholac 14 Citroma 16 Citrucel Orange Flavor 3 Citrucel Sugar-Free Orange Flavor 3 Col more...

Palivizumab Palivizumab
Generic Name: Palivizumab (pal-i-VIZ-u-mab) Brand Name: SynagisPalivizumab is used for:Preventing serious lower respiratory tract infection caused by respiratory syncytial virus (RSV) in children at high risk of RSV disease. Palivizumab is a monoclonal antibody. It works by preventing RSV from more...

Paxil Suspension Paxil Suspension
Generic Name: Paroxetine Suspension (par-OX-e-teen) Brand Name: Paxil Antidepressants may increase the risk of suicidal thoughts or actions in children and teenagers. The risk may be greater during the first few months that patients take Paxil Suspension. Be sure that the benefits of using Paxil more...

pheniramine/pyrilamine/phenylpropanolamine pheniramine/pyrilamine/phenylpropanolamine
Generic Name: pheniramine/pyrilamine/phenylpropanolamine (fen IR a meen/pie RILL a meen/fen ill proe pa NOLE a meen) Brand Names: Liqui-Minic Infant, Triactin, Triaminic Infant, Triaminic Pediatric What is pheniramine/pyrilamine/phenylpropanolamine? Pheniramine and pyrilamine are antihis more...

PMS-Cimetidine PMS-Cimetidine
Some commonly used brand names are: In the U.S.— Axid 3 Axid AR 3 Fluxid 2 Mylanta AR Acid Reducer 2 Pepcid 2 Pepcid I.V. 2 Pepcid AC Acid Controller 2 Pepcid RPD 2 Tagamet 1 Tagamet HB 1 Zantac 4 Zantac 150 4 Zantac 300 4 Zantac 25 EFFERdose Tablets 4 Zantac 150 EFFERdose Tablets 4 In C more...