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All about: Mycobutin

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Generic Name: rifabutin (rif a BYOO tin)
Brand Names: Mycobutin

What is Mycobutin (rifabutin)?

Rifabutin is an antibiotic. It prevents bacteria from multiplying in your body.

Rifabutin is used to prevent Mycobacterium avium complex (MAC) in people with advanced human immunodeficiency virus (HIV) infection.

Rifabutin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Mycobutin (rifabutin)?

Take all of the rifabutin that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated.

Call your doctor immediately if you experience a fever, chills, muscle or bone pain, blurred vision, eye pain or redness, a headache, excessive tiredness or weakness, a sore throat, unusual bleeding or bruising, or yellow skin or eyes.

Rifabutin may decrease the effectiveness of birth control pills. Talk to your doctor about using another form of birth control during treatment with rifabutin to prevent pregnancy.

Who should not take Mycobutin (rifabutin)?

You cannot take rifabutin if you have
  • ever had an allergic reaction to rifabutin;

  • active tuberculosis. Rifabutin will not effectively treat active tuberculosis, and it may cause the infection to become resistant to treatment.

Rifabutin is in the FDA pregnancy category B. This means that it is not likely to harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is not known whether rifabutin passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take Mycobutin (rifabutin)?

Take rifabutin exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass (8 ounces) of water.

Rifabutin can be taken with or without food. Taking rifabutin with food may decrease stomach upset.

The capsules can be opened and sprinkled onto applesauce if you have trouble swallowing them.

Take all of the rifabutin that has been prescribed for you even if you begin to feel better. Your symptoms may begin to improve before the infection is completely treated. Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a rifabutin overdose are unknown but might include nausea, vomiting, tiredness, abdominal pain, yellow skin or eyes, and unconsciousness.

What should I avoid while taking Mycobutin (rifabutin)?

Do not wear contact lenses while taking rifabutin. This medicine may turn your tears, sweat, saliva, urine, feces, and contact lenses a red-orange color. This effect may be permanent on contact lenses.

Rifabutin may decrease the effectiveness of birth control pills. Talk to your doctor about using another form of birth control to prevent pregnancy during treatment with rifabutin.

Mycobutin (rifabutin) side effects

If you experience any of the following serious side effects, stop taking rifabutin and seek emergency medical attention:
  • an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

  • fever, chills, or a sore throat;

  • muscle or bone pain;

  • excessive tiredness or weakness;

  • a headache;

  • blurred vision;

  • eye pain or redness;

  • unusual bruising or bleeding; or

  • yellow skin or eyes.

Other, less serious side effects may be more likely to occur. Continue to take rifabutin and talk to your doctor if you experience

  • red-orange coloration of tears, sweat, saliva, urine, or feces;

  • nausea, vomiting, diarrhea, or decreased appetite;

  • changes in taste;

  • insomnia; or

  • a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect Mycobutin (rifabutin)?

Rifabutin may decrease the effects of the following drugs:

  • acetaminophen (Tylenol, others);

  • blood thinners such as warfarin (Coumadin);

  • barbiturates such as phenobarbital (Luminal, Solfoton), amobarbital (Amytal), secobarbital (Seconal), and butabarbital (Butisol);

  • benzodiazepines such as alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), and temazepam (Restoril);
  • beta-blockers such as atenolol (Tenormin), propranolol (Inderal), and metoprolol (Lopressor);
  • heart medicines such as digoxin (Lanoxin), disopyramide (Norpace), quinidine (Quinora, Quinidex, Cardioquin, others), mexiletine (Mexitil), tocainide (Tonocard), verapamil (Calan, Verelan, Isoptin), and enalapril (Vasotec);

  • corticosteroids such as prednisone (Deltasone, Orasone, Meticorten), prednisolone (Delta Cortef, Prelone, others), methylprednisolone (Medrol), and betamethasone (Celestone);

  • sulfonylureas such as glipizide (Glucotrol), glyburide (Micronase, Diabeta, Glynase), chlorpropamide (Diabinese), tolbutamide (Orinase), and tolazamide (Tolinase);

  • sulfa medicines such as sulfamethoxazole (Bactrim, Septra, Gantanol, Azo-Gantanol), and sulfisoxazole (Gantrisin, Azo-Gantrisin);

  • estrogens such as Premarin, Ogen, Estrace, Menest, Estratab, Ortho-Est, and others;

  • oral birth control pills such as Triphasil, Ortho-Novum, Ortho-Cyclen, Ortho-Tri-Cyclen, Ovral, Lo/Ovral, Desogen, Nordette, Levora, Levlen, Tri-Levlen, Nelova, Norinyl, Brevicon, Ovcon, Loestrin, Demulen, and others;

  • phenytoin (Dilantin), ethotoin (Peganone), and mephenytoin (Mesantoin);

  • theophylline (Theolair, Theo-Dur, Theochron, Theo-Bid, others);

  • methadone (Dolophine);

  • clofibrate (Atromid-S);

  • cyclosporine (Sandimmune, Neoral);

  • zidovudine (AZT, Retrovir); and

  • ketoconazole (Nizoral), itraconazole (Sporanox), and fluconazole (Diflucan).

You may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Before taking rifabutin, tell your doctor if you are taking

  • delavirdine (Rescriptor),

  • indinavir (Crixivan),

  • saquinavir (Invirase),

  • ritonavir (Norvir), or

  • nelfinavir (Viracept).

Rifabutin may interact with the medicines listed above which could lead to dangerous side effects.

Drugs other than those listed here may also interact with rifabutin or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

  • Your pharmacist has additional information about rifabutin written for health professionals that you may read.

What does my medication look like?

Rifabutin is available with a prescription under the brand name Mycobutin. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Mycobutin 150 mg--red and brown capsules

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 2.02. Revision Date: 2/19/03 4:27:18 PM.

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