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All about: Nadolol

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Generic Name: Nadolol (nay-DOE-lahl)
Brand Name: Corgard

If you suddenly stop taking certain medicines, sharp chest pain, and in some cases heart attack, may occur. When stopping treatment with Nadolol , your doctor will need to slowly decrease your dose over a period of 1 to 2 weeks and will watch you closely for side effects, particularly if you have certain kinds of heart disease. If chest pain becomes more severe or a heart problem develops, Nadolol should be restarted at once, at least temporarily, and other measures to help unstable chest pain should be taken. Because heart artery disease is common and you may not know that you have it, it may be safer not to stop Nadolol quickly even if you are only being treated for high blood pressure.


Nadolol is used for:

Long-term management of chest pain or high blood pressure. It may be used alone or with other high blood pressure medicines. It may also be used to treat other conditions as determined by your doctor.

Nadolol is a beta-blocker. It works by interfering with the certain body chemicals, which cause the heart to beat with less force and pump out less blood. This allows the heart to beat more slowly and regularly. By blocking these chemicals, blood vessels are relaxed and widened, allowing blood pressure to decrease.

Do NOT use Nadolol if:

  • you are allergic to any ingredient in Nadolol
  • you have asthma or a serious heart problem, including a blockage, heart attack, heart failure, very slow heartbeat, or low blood pressure
  • you are currently taking indomethacin or one of its derivatives, mibefradil, stimulants (eg, epinephrine), or a theophylline

Contact your doctor or health care provider right away if any of these apply to you.

Before using Nadolol :

Some medical conditions may interact with this medicine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, plan to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have breathing problems (including chronic obstructive pulmonary disease [COPD]), diabetes, congestive heart failure, overactive thyroid, kidney or circulation problems, or a tumor on your adrenal gland, or about to have major surgery

Some MEDICINES MAY INTERACT with Nadolol . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Phenylpropanolamine or indomethacin because they may decrease the effectiveness of Nadolol
  • Disopyramide, flecainide, ketanserin, mefloquine, mibefradil, quinazolines (eg, prazosin), or verapamil because they may increase the actions and side effects of Nadolol
  • Bupivacaine, disopyramide, flecainide, insulin, ketanserin, intravenous (IV) lidocaine, meglitinide antidiabetics (eg, repaglinide), or epinephrine because their actions and side effects may be increased by Nadolol
  • Clonidine because if either medicine is stopped, high blood pressure may occur
  • Stimulants (eg, albuterol, amphetamine, pseudoephedrine) or theophyllines because their effectiveness may be decreased by Nadolol

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nadolol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Nadolol :

Use Nadolol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Nadolol may be taken with or without food.
  • Take Nadolol regularly to receive the most benefit from it. Taking Nadolol at the same times each day will help you to remember to take it.
  • Continue to take Nadolol even if you feel well. Do not miss any doses.
  • If Nadolol is stopped or if a different medicine is added to therapy, this should be done gradually. The risk of side effects, such as chest pain, heart palpitations, sweating, and headache, may be increased if Nadolol is suddenly stopped.
  • If you miss a dose of Nadolol , take it as soon as you remember if it is more than 8 hours before the next dose is due. If it is less than 8 hours until your next dose, skip the missed dose and return to your normal dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Nadolol .

Important safety information:

  • Nadolol may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Nadolol
  • Patients being treated for high blood pressure often feel tired or run down for a few weeks after beginning treatment. Continue taking your medicine even though you may not feel quite "normal." Contact your doctor or pharmacists about any new symptoms.
  • Do not suddenly stop taking Nadolol without talking without your health care provider, especially if you have heart disease. The dose should be reduced gradually over a period of 1 to 2 weeks. If chest pain becomes worse or heart problems develop, Nadolol should be restarted at least temporarily along with other medical treatment.
  • If your doctor has instructed you to check your blood pressure and heart rate regularly, be sure to do so.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Nadolol .
  • Patients being treated for high blood pressure should avoid using nonprescription medicines that contain stimulants, such as products used for dieting (appetite suppressants) or for cold symptoms (eg, pseudoephedrine).
  • Diabetic patients - Nadolol may mask signs of low blood sugar (eg, increased heartbeat, headache, chills, sweating, tremor, increased hunger, changes in vision, nervousness, weakness, dizziness, drowsiness, fainting). Check blood glucose levels regularly.
  • LAB TESTS, including blood pressure, electrocardiogram (ECG), heart rate, and heart function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Nadolol during pregnancy. Nadolol is excreted in breast milk. If you are or will be breast-feeding while you are using Nadolol , check with your doctor or pharmacist to discuss the risks to your baby.

If you suddenly stop taking Nadolol , you may experience WITHDRAWAL symptoms, including fast heartbeat, low blood pressure, chest pain, and nervousness.

Possible side effects of Nadolol :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; fatigue; lightheadedness; mild drowsiness; slow heartbeat; unusual tiredness or weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue).

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include difficult or slowed breathing; fainting; severe dizziness; slow heartbeat; weakness.

Proper storage of Nadolol :

Store Nadolol at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep bottle tightly closed. Keep Nadolol out of the reach of children and away from pets.

General information:

  • If you have any questions about Nadolol , please talk with your doctor, pharmacist, or other health care provider.
  • Nadolol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Nadolol . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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