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All about: Naratriptan

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Generic Name: Naratriptan (NAHR-ah-trip-tan)
Brand Name: Amerge

Naratriptan is used for:

Relieving migraine headache attacks as they occur. Naratriptan will not prevent or reduce the number of attacks you experience. Naratriptan may also be used to treat other conditions as determined by your doctor.

Naratriptan is a serotonin 5-HT1 receptor agonist. It works by constricting dilated blood vessels in the brain.

Do NOT use Naratriptan if:

  • you are allergic to any ingredient in Naratriptan
  • you have heart disease, angina (chest pain), hemiplegic or basilar migraines, severe liver or kidney problems, blood flow problems, or uncontrolled high blood pressure, or you have had a stroke
  • you have taken an ergot alkaloid or another 5-HT1 receptor agonist within the last 24 hours

Contact your doctor or health care provider right away if any of these apply to you.

Before using Naratriptan :

Some medical conditions may interact with Naratriptan . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have peripheral vascular disease, fast or irregular heartbeat, shortness of breath, seizures, high blood pressure, heart problems, or a family history of coronary artery disease
  • if you smoke or are overweight
  • if you suffer from cluster headaches
  • if you have diabetes, high cholesterol, or kidney or liver disease
  • if you are a woman past menopause or have had a hysterectomy

Some MEDICINES MAY INTERACT with Naratriptan . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the effectiveness of Naratriptan may be decreased
  • Dexfenfluramine, monoamine oxidase (MAO) inhibitors (eg, phenelzine), SSRIs (eg, fluoxetine), or sibutramine because side effects, such as increased spasms in the blood vessels or serotonin syndrome (eg, restlessness, excessive sweating, or seizures), may occur
  • Ergot alkaloids (eg, ergotamine) because side effects, such as increase in blood vessel constriction resulting in high blood pressure or decrease in blood flow, may occur from these medicines

This may not be a complete list of all interactions that may occur. Ask your health care provider if Naratriptan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Naratriptan :

Use Naratriptan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Naratriptan may be taken with or without food.
  • Swallow whole. Do not break, crush, or chew before swallowing.
  • It is best to take a dose of Naratriptan as soon as you notice headache symptoms of a migraine attack.
  • If your headache returns or you get partial relief, you may take another dose. Allow at least 4 hours between doses of Naratriptan .
  • If you do not get a response from the first dose, do not take additional doses without checking with your doctor.
  • Do not take more than 2 doses in a 24 hour period.
  • If you miss a dose of Naratriptan and you still have a headache, follow your doctor's dosing instructions. Contact your doctor if you are unsure what to do if you miss a dose. Do not take Naratriptan more often than prescribed. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Naratriptan .

Important safety information:

  • Naratriptan may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Naratriptan . Using Naratriptan alone, with certain other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
  • Naratriptan may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Naratriptan . Use a sunscreen or protective clothing if you must be outside for a prolonged period.
  • Naratriptan is not intended to prevent or reduce the number of migraine attacks that you experience.
  • If you have a headache that is different than your usual migraine attacks, check with your doctor before using Naratriptan .
  • Diabetes patients - Naratriptan may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
  • Use Naratriptan with caution in the ELDERLY because they may be more sensitive to its effects.
  • Use Naratriptan with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Naratriptan during pregnancy. It is unknown if Naratriptan is excreted in breast milk. Do not breast-feed while taking Naratriptan .

Possible side effects of Naratriptan :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; nausea; neck and throat symptoms; numbness or tingling of the skin; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain, pressure, or heaviness; heart pounding; severe heart problems; shortness of breath; sudden or severe stomach pain; tightness in the jaw, neck, or chest; wheezing.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include severe drowsiness.

Proper storage of Naratriptan :

Store Naratriptan at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, light, and moisture. Do not store in the bathroom. Keep Naratriptan out of the reach of children and away from pets.

General information:

  • If you have any questions about Naratriptan , please talk with your doctor, pharmacist, or other health care provider.
  • Naratriptan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Naratriptan . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition 07.3.1.003
Copyright © 2007 Wolters Kluwer Health, Inc.

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