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All about: Nepafenac

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Some commonly used brand names are:

In the U.S.—

  • Nevanac

Not commercially available in Canada.

Category

  • Anti-inflammatory, nonsteroidal, ophthalmic

Description

Nepafenac ((ne-pa-FEN-ak )) is an ophthalmic anti-inflammatory medicine used in the eye to relieve pain and inflammation or edema (too much fluid in the eye) that can occur during or after some kinds of eye surgery.

This medicine is available only with your doctor's prescription, in the following dosage forms:

  • Ophthalmic
  • Ophthalmic solution (eye drops) (U.S.)

Before Using This Medicine

In deciding to use a medicine, the risks of using the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nepafenac ophthalmic, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to nepafenac. Also tell your doctor and pharmacist if you are allergic to any other substances, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or foods, preservatives, or dyes.

Pregnancy—Nepafenac has not been studied in pregnant women. However, studies in animals have shown that nepafenac causes unwanted effects. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—It is not known whether nepafenac eye drops pass into the breast milk. Most medicines pass into breast milk in small amounts. It may be necessary for you to take another medicine or to stop breast feeding during treatment. Be sure you discuss the risks and benefits of this medicine with your doctor.

Children—Nepafenac eye drops have only been studied in children age 10 years and older. Discuss with your child's doctor the good that this medicine may do as well as the risks of using it.

Other medical problems—The presence of other medical problems may affect the use of nepafenac. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bleeding problems—The possibility of bleeding may be increased
  • Use of soft contact lenses—Eye irritation, such as redness and burning of the eyes, may occur
  • Vision problems—The possibility of increased side effects and loss of vision

Proper Use of This Medicine

To use :

  • First, wash your hands. Tilt the head back and, pressing your finger gently on the skin just beneath the lower eyelid, pull the lower eyelid away from the eye to make a space. Drop the medicine into this space. Let go of the eyelid and gently close the eyes. Do not blink. Keep the eyes closed and apply pressure to the inner corner of the eye with your finger for 1 or 2 minutes to allow the medicine to be absorbed by the eye.
  • Immediately after using the eye drops, wash your hands to remove any medicine that may be on them.
  • To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface (including the eye). Also, always keep the container tightly closed.

Dosing—The dose of nepafenac drops will be different for different patients. Follow your doctor's orders or the directions on the label . The following information includes only the average doses of nepafenac. If your dose is different, do not change it unless your doctor tells you to do so.

  • For ophthalmic solution (eye drops) dosage form:
    • Inflammation in the eye following cataract surgery
      • Adults—1 drop in the eye three times a day beginning 1 day before cataract surgery and on the day of surgery and throughout the first two weeks following surgery.
      • Children—Use and dose must be determined by your doctor.

Missed dose—Using as soon as possible; not using if almost time for next dose; using next dose at regularly scheduled time; not doubling doses

Storage—To store this medicine:

  • Keep out of the reach of children.
  • Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

Wearing soft contact lenses during treatment with nepafenac has caused severe irritation (redness and itching) in some people. Therefore, do not wear soft contact lenses during the time that you are being treated with nepafenac .

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Seeing flashes or sparks of light; seeing floating spots before the eyes, or a veil or curtain appearing across part of vision

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome.

More Common

Blurred vision; change in vision; decrease in vision; feeling of having something in the eye; loss of vision; sticky sensation of eyelids

Less common

Change in color vision; cough; crusting in corner of eye; difficulty seeing at night; dizziness; dry eye; eye itching; eye pain; fever; headache; increased sensitivity of eyes to sunlight; nausea; nervousness; pain in eye; pounding in the ears; redness of eye; shortness of breath or troubled breathing; slow or fast heartbeat; stuffy or runny nose; swelling and/or redness of eye and lining of eyelid; tenderness around eyes and cheekbone; tearing; tightness of chest or wheezing; vomiting

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

Developed: 09/23/2005

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