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All about: Neupro

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Generic Name: Rotigotine Transdermal System (roe-TIG-oh-teen)
Brand Name: Neupro

Neupro is used for:

Treating Parkinson disease.

Neupro is a dopamine agonist. It works in certain areas of the brain to reduce the symptoms (eg, tremor, uncontrolled muscle movements) of the early stages of Parkinson disease.

Do NOT use Neupro if:

  • you are allergic to any ingredient in Neupro

Contact your doctor or health care provider right away if any of these apply to you.

Before using Neupro :

Some medical conditions may interact with Neupro . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have heart problems (eg, heart failure, heart disease), blood vessel problems, high or low blood pressure, liver problems, kidney problems, lung problems, asthma, or a sleep disorder
  • if you smoke or have a personal or family history of addiction (eg, gambling, alcohol)
  • if you are scheduled to have magnetic resonance imaging (MRI) or a procedure to treat an irregular heartbeat (cardioversion)

Some MEDICINES MAY INTERACT with Neupro . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Benzodiazepines (eg, diazepam), medicines for mental or mood problems (eg, antidepressants, antipsychotics), or medicines for sleep (eg, zolpidem) because the risk of severe drowsiness may be increased
  • Dopamine antagonists (eg, phenothiazines) or metoclopramide because they may decrease Neupro 's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Neupro may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Neupro :

Use Neupro as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Neupro . Talk to your pharmacist if you have questions about this information.
  • Apply Neupro only to dry, intact skin on the upper torso, upper thigh, stomach, or outer surface of the upper arm as directed by your doctor or on the package labeling.
  • Do not apply Neupro to hairy, oily, irritated, broken, scarred, or calloused skin. If you must apply Neupro to a hairy area of skin, shave the hair from the area at least 3 days before you apply Neupro to that area.
  • Do not place the patch under tight clothing. Do not apply creams, lotions, ointments, oils, or powders to the skin where the patch will be applied. Never cut or tear the patch.
  • To use Neupro , gently wash the application site with soap and warm water. Rinse until all soap is removed. Dry the area with a clean, dry towel.
  • Remove the patch from its sealed pouch and peel away one side of the protective liner. Apply the sticky side of the patch to the skin. Peel away the rest of the liner so that the patch lies flat against the skin. There should be no bumps or folds in the patch. Press the patch against your skin firmly with the palm of your hand for 20 to 30 seconds to make sure there is good contact with the skin.
  • Wash your hands thoroughly with soap and water after applying Neupro . Do not touch your eyes until after you have washed your hands.
  • After 24 hours, remove the used patch and fold it in half with the sticky sides together. Discard out of the reach of children and away from pets. Wash the area with mild soap and warm water to remove any adhesive remaining on the skin. Apply a new patch to a different area of skin. Use a new application site each time you apply a new patch. Do not apply a patch to the same area of skin within 14 days.
  • If you have questions about how to use Neupro , check with your doctor or pharmacist.
  • Continue to use Neupro even if you feel well. Do not miss any doses.
  • If your patch falls off, apply a new patch for the rest of the day.
  • If you miss a dose of Neupro , remove the old patch and apply a new patch to a different area of skin. Go back to your regular dosing schedule. Do not wear 2 patches at once.

Ask your health care provider any questions you may have about how to use Neupro .

Important safety information:

  • Neupro may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Neupro with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Neupro ; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Some people who use Neupro may experience sudden onset of severe drowsiness or may even fall asleep during normal daily activities (eg, eating, talking, driving). This could occur without warning. If this happens, do not drive, operate machinery, or perform other possibly unsafe tasks while you use Neupro . Tell your doctor right away.
  • Some people have experienced new, unusual, or increased urges (eg, gambling, sexual urges) while using Neupro or other medicines used to treat Parkinson disease. Tell your doctor right away if you notice such effects.
  • Neupro may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do not apply heating pads, electric blankets, or other such sources of heat to the area where you apply Neupro . Avoid other sources of heat such as heat lamps; saunas; hot tubs; heated waterbeds; long, hot baths; or prolonged, direct exposure to sunlight while using Neupro . Heat may increase the amount of Neupro released into your skin.
  • Tell your doctor or dentist that you take Neupro before you receive any medical or dental care, emergency care, or surgery.
  • Remove Neupro from the skin before you have certain medical tests or treatments (eg, MRI, cardioversion). It may become hot and cause burns if left on the skin during such procedures.
  • Do not suddenly stop using Neupro without checking with your doctor. Doing so may cause withdrawal symptoms, including fever, confusion, muscle stiffness, and kidney problems.
  • Lab tests, including skin exams, may be performed while you use Neupro . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Neupro with caution in the ELDERLY; they may be more sensitive to its effects.
  • Neupro should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Neupro while you are pregnant. It is not known if Neupro is found in breast milk. Do not breast-feed while taking Neupro .

Possible side effects of Neupro :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back or joint pain; constipation; decreased appetite; dizziness; drowsiness; dry mouth; fatigue; headache; increased sweating; minor redness, swelling, or itching at the application site; nausea; trouble sleeping; upset stomach; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal dreams; chest pain; confusion; difficult or decreased urination; fainting; fast, slow, or irregular heartbeat; fever; hallucinations; leg pain; loss of coordination; numbness or tingling of the skin; rigid muscles; sudden, severe drowsiness or falling asleep during normal daily activities; swelling of the arms or legs; trouble swallowing; unusual tiredness or weakness; vision changes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include confusion; dizziness; hallucinations; nausea; seizures; unusual movements; vomiting.

Proper storage of Neupro :

Store Neupro at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store in the original packaging until just before use. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Neupro out of the reach of children and away from pets.

General information:

  • If you have any questions about Neupro , please talk with your doctor, pharmacist, or other health care provider.
  • Neupro is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Neupro . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: September 5, 2007
Database Edition
Copyright © 2007 Wolters Kluwer Health, Inc.

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