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All about: nisoldipine

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Generic Name: nisoldipine (oral) (nye ZOLE dih peen)
Brand Names: Sular

What is nisoldipine?

Nisoldipine is in a class of drugs called calcium channel blockers. Nisoldipine relaxes (widens) your blood vessels (veins and arteries), which makes it easier for the heart to pump and reduces its workload.

Nisoldipine is used to treat hypertension (high blood pressure).

Nisoldipine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about nisoldipine?

Do not stop taking nisoldipine without first talking to your doctor, even if you begin to feel better. If you stop taking the medication, your condition could become worse. Do not crush, chew, or break the tablets. Swallow them whole. They are specially formulated to release the medication slowly in the body. Do not consume grapefruit or grapefruit juice during treatment with nisoldipine. Nisoldipine can interact with grapefruit and grapefruit juice, and the interaction may have dangerous effects. You should discuss the use of grapefruit and grapefruit juice with your doctor.

Do not take nisoldipine with fatty foods. Fatty foods may increase the amount of nisoldipine in the blood to unsafe levels.

What should I discuss with my healthcare provider before taking nisoldipine?

Before taking nisoldipine, tell your doctor if you have

  • kidney disease;
  • liver disease; or
  • another disease of the heart or blood vessels such as sick sinus syndrome, aortic stenosis, heart failure, low blood pressure, or coronary artery disease.

You may not be able to take nisoldipine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Nisoldipine is in the FDA pregnancy category C. This means that it is not known whether nisoldipine will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether nisoldipine passes into breast milk or how it may affect a nursing infant. Do not take nisoldipine without first talking to your doctor if you are breast-feeding a baby. If you are over 65 years of age, you may be more likely to experience side effects from nisoldipine. Your doctor may prescribe a lower dose of this medication.

How should I take nisoldipine?

Take nisoldipine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Nisoldipine is usually taken once a day. Follow your doctor's instructions.

Do not take nisoldipine with fatty foods. Fatty foods may increase the amount of nisoldipine in the blood to unsafe levels.

Do not consume grapefruit or grapefruit juice during treatment with nisoldipine. Nisoldipine can interact with grapefruit and grapefruit juice, and the interaction may have dangerous effects. You should discuss the use of grapefruit and grapefruit juice with your doctor. Do not crush, chew, or break the tablets. Swallow them whole. They are specially formulated to release the medication slowly in the body. Do not stop taking nisoldipine without first talking to your doctor, even if you begin to feel better. If you stop taking the medication, your condition could become worse. Store nisoldipine at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of a nisoldipine overdose are unknown, but might include dizziness, weakness, chest pain, shortness of breath, fainting, an unusually fast or slow heartbeat, coma, slurred speech, and confusion.

What should I avoid while taking nisoldipine?

Do not take nisoldipine with fatty foods. Fatty foods may increase the amount of nisoldipine in the blood to unsafe levels.

Do not consume grapefruit or grapefruit juice during treatment with nisoldipine. Nisoldipine can interact with grapefruit and grapefruit juice, and the interaction may have dangerous effects. You should discuss the use of grapefruit and grapefruit juice with your doctor.

Follow any recommendations your doctor makes about diet or exercise.

Use caution when you stand or sit up from a lying position, especially if you wake up during the night. You may become dizzy when changing positions. Use alcohol cautiously. Alcohol may further lower blood pressure and increase drowsiness or dizziness while taking nisoldipine.

Nisoldipine side effects

If you experience any of the following serious side effects, stop taking nisoldipine and contact your doctor immediately or seek emergency medical treatment:
  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

  • unusually fast or slow heartbeats;

  • fainting or severe dizziness;

  • abnormal behavior or psychosis;

  • chest pain or worsening angina;

  • jaundice (yellowing of the skin or eyes); or

  • swelling of the legs or ankles.

Other, less serious side effects may be more likely to occur. Continue to take nisoldipine and talk to your doctor if you experience

  • unusual headache, fatigue, or tiredness;

  • insomnia;

  • vivid or abnormal dreams;

  • increased or difficult urination;

  • mild dizziness;

  • flushing;

  • a rash; or

  • nausea.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What other drugs will affect nisoldipine?

Before taking nisoldipine, tell your doctor if you are taking any of the following drugs:

  • another heart medication to treat the same or another condition;

  • cimetidine (Tagamet, Tagamet HB);

  • erythromycin (E-Mycin, E.E.S., Eryc, Ery-Tab, others);

  • itraconazole (Sporanox) or ketoconazole (Nizoral);

  • carbamazepine (Tegretol);

  • phenytoin (Dilantin); or

  • rifampin (Rifadin, Rimactane) or rifabutin (Mycobutin).

You may not be able to take nisoldipine, or you may require a dosage adjustment or special monitoring if you are taking any of the medicines listed above.

Drugs other than those listed here may also interact with nisoldipine or affect your condition. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Where can I get more information?

  • Your pharmacist has additional information about nisoldipine written for health professionals that you may read.

What does my medication look like?

Nisoldipine is available with a prescription under the brand name Sular. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Sular 10 mg--off-white, round, film-coated tablets

  • Sular 20 mg--yellow-cream-colored, round, film-coated tablets

  • Sular SR 30 mg--mustard-colored, round, film-coated tablets

  • Sular SR 40 mg--burnt-orange, round, film-coated tablets

  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the condition prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 2.05. Revision Date: 8/31/04 4:45:05 PM.

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